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Altered expression of immune surface markers in children with recurrent infections of respiratory tract

100%

Wasik M., Kaczorowska M., Demkow U.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 4

237-243

Infections of the respiratory tract are very common in young children. They may affect the quality of life and have a great economic impact. On the other hand, respiratory tract infections through MALT system play a positive role in the maturation and development of the immune system. The aim of the study was to examine quantitative and qualitative changes of T and B cells and granulocytes surface molecules in 24 children with recurrent (more than 8 episodes per year) infections of the respiratory tract and in 18 healthy children. The expression of CD2, CD3, CD4, CD8 on T cells; HLA-DR, CD19, CD5/CD20 on B cells, and CD11a/CD18, CD11b/CD18, CD62L, CD16 on granulocytes from peripheral blood was evaluated by a flow cytometry method. We observed a significant increase in the CD5+/CD20+ positive cells on B cells. We also observed a decreased expression of CD11c+/CD18+ cells, CD11a, and CD62L on granulocytes. The expression of other structures on lymphocytes and the CD11b/CD18+ on granulocytes remained unchanged. CD5+/CD20+ cells constitute a filogenetically old population responsible for the production of IgM of low specificity and affinity for specific antigens. The prevalence of this fetal phenotype population may be explained as a delayed maturation of the humoral immune system leading to increased susceptibility to infections. A lower percentage of CD11a may be related to the blockade of that molecule by rhinoviruses.

Toll-like receptors’ pathway disturbances are associated with increased susceptibility to infections in humans

67%

Frazao J. B., Errante P. R., Condino-Neto A.

Archivum Immunologiae et Therapiae Experimentalis

2013

tom 61

nr 6

A randomised, double-blind study on the efficacy of Tolpa Torf Preparation [TTP] in the treatment of recurrent respiratory tract infections

67%

Jankowski A., Nienartowicz B., Polanska B., Lewandowicz-Uszynska A.

Archivum Immunologiae et Therapiae Experimentalis

1993

tom 41

nr 1

Ograniczanie wyników

2 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Physiology and Pharmacology. Supplement

1 Condino-Neto A.

1 Demkow U.

1 Errante P. R.

1 Frazao J. B.

1 Jankowski A.

1 Kaczorowska M.

1 Lewandowicz-Uszynska A.

1 Nienartowicz B.

1 Polanska B.

1 Wasik M.

1 2013

1 2005

1 1993

Wyniki wyszukiwania

Altered expression of immune surface markers in children with recurrent infections of respiratory tract

Toll-like receptors’ pathway disturbances are associated with increased susceptibility to infections in humans

A randomised, double-blind study on the efficacy of Tolpa Torf Preparation [TTP] in the treatment of recurrent respiratory tract infections