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Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells

100%

Siedlecka-Kroplewska K., Jozwik A., Kaszubowska L., Kowalczyk A., Boguslawski W.

Folia Histochemica et Cytobiologica

2012

tom 50

nr 4

In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs

100%

Billack B., Radkar V., Adiabouah C.

Cellular and Molecular Biology Letters

2008

tom 13

nr 4

553-569

Resveratrol (RES), a component of red wine, possesses anti-inflammatory properties. The studies described in the present work were aimed at evaluating the potential for RES and related stilbene analogs (piceatannol, PIC; pterostilbene, TPS; trans-stilbene, TS; and trans-stilbene oxide, TSO) to exhibit toxicity towards RAW 264.7 mouse macrophages. The effect of TS, TSO, RES and TPS on RAW 264.7 macrophage viability was determined by two standard methods: (a) the MTT assay and (b) the trypan blue dye exclusion test. Whereas macrophages were more sensitive to PIC (LC50 trypan ∼ 1.3 μM) and to TPS (LC50 trypan ∼ 4.0 μM and LC50 MTT ∼ 8.3 μM) than to RES (LC50 trypan ∼ 8.9 μM and LC50 MTT ∼ 29.0 μM), they were relatively resistant to TSO (LC50 trypan ∼ 61.0 μM and LC50 MTT > 100 μM) and to TS (LC50 trypan ≥ 5.0 μM and LC50 MTT ≥ 5.0 μM). The ability of selected stilbenes (RES, TPS and PIC) to exhibit growth inhibitory effects was also examined. Although RES and TPS were observed to inhibit cell proliferation in macrophages (IC50 ≤ 25 μM), these cells were resistant to growth inhibition by PIC (IC50 ≥ 50 μM). The data obtained in the present analysis demonstrate that substituted stilbene compounds such as RES have the capacity to exhibit cytotoxic and anti-proliferative activities in macrophages.

Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells

80%

Siedlewska-Kroplewska K., Jozwik A., Boguslawski W., Wozniak M., Zauszkiewicz-Pawlak A., Spodnik J. H., Rychlowski M., Kmiec Z.

Journal of Physiology and Pharmacology

2013

tom 64

nr 5

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Folia Histochemica et Cytobiologica

1 Journal of Physiology and Pharmacology

2 Boguslawski W.

2 Jozwik A.

1 Adiabouah C.

1 Billack B.

1 Kaszubowska L.

1 Kmiec Z.

1 Kowalczyk A.

1 Radkar V.

1 Rychlowski M.

1 Siedlecka-Kroplewska K.

1 Siedlewska-Kroplewska K.

1 Spodnik J. H.

1 Wozniak M.

1 Zauszkiewicz-Pawlak A.

1 2013

1 2012

1 2008

Wyniki wyszukiwania

Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells

In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs

Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells