Wyniki wyszukiwania

1

Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

100%

Niedzielska I., Niedzielski Z., Tkacz M., Orawczyk T., Ziaja K., Starzewski J., Mazurek U., Markowski J.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 1

65-71

The aim of this study was to identify differences in Toll-like receptor (TLR) expression patterns in normal and diseased tissues of patients with polyps and colorectal cancer. Eight patients were included in the study group (aged 38 to 72 years). Sixteen HG-U133A oligonucleotide microarrays were analysed including four of colonic polyps, four of adenocarcinoma with different degree of histological differentiation (2 poorly and 2 highly differentiated), and eight of macroscopically normal tissue. The levels of selected TLR mRNA transcripts were analysed. An analysis of all per cent variability values with regard to malignancy stage increasing from polyp to stages I to III adenocarcinoma, and normal colon mucosa shows a statistically significant relationship for TLR2 (increasing) and TLR3 (decreasing). In polyps, copy numbers of TLR3, TLR4 and TLR5 mRNA were the highest and TLR7 mRNA the lowest. In normal colon mucosa of polyposis patients the highest mRNA copy numbers were observed for TLR3, and the lowest for TLR7. TLR3 may serve as a marker of colon tissue metaplasia and may indicate the tendency of normal tissue to form polyps transforming to colorectal cancer.

2

Role of monocytes in the pathogenesis of dengue

100%

Castillo J. A., Naranjo J. S., Rojas M., Castano D., Velilla P. A.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

|

nr 1

3

Proinflammatory cytokines and Helicobacter pylori stimulate C-C chemokine expression in gastric epithelial cells

100%

Terano A., Shimada T., Ohtsuka Y., Watanabe N., Hiraishi H.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

|

nr 1

4

Contribution of tumor necrosis factor alpha to the pathogenesis of stroke

100%

Zaremba J.

Folia Morphologica

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2000

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tom 59

|

nr 3

Tumor necrosis factor alpha (TNF-alpha) is a protein of a cellular origin belonging to a group of proinflammatory cytokines. A rapid overproduction of TNF-alpha in a cerebral post-ischemic inflammatory response leads to the stimulation of adhesive molecules expression with subsequent accumulation of leukocytes in the ischemic focus, which is preceded by their adhesion and migration. The TNF-alpha proinflammatory activity results mainly in extending the area of the brain infarct, which brings about negative clinical implications. Being the final morphological effect of ischemic stroke, TNF-alpha appears also to contribute to neuronal necrosis by its involvement in the process of apoptosis as well as in the death of neurons. The present study describes and discusses mainly the contribution of TNF-alpha to the formation of ischemic focus in the brain.

5

The effect of estrogen receptor agonists on pancreaticobiliary duct ligation induced experimental acute pancreatitis

84%

Guleken Z., Ozbeyli D., Acikel-Elmas M., Oktay S., Alev B., Sirvanci S., Velioglu Ogunc A., Kasimay Cakir O.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 6

6

Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats

84%

Kumral Z. N. O., Sener G., Ozgur S., Koc M., Suleymanoglu S., Hurdag C., Yegen B. C.

Journal of Physiology and Pharmacology

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2016

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tom 67

|

nr 1

7

Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis

84%

Celinski K., Dworzanski T., Fornal R., Korolczuk A., Madro A., Brzozowski T., Slomka M.

Journal of Physiology and Pharmacology

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2013

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tom 64

|

nr 5

8

Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma

84%

Grzela K., Zagorska W., Krejner A., Litwiniuk M., Zawadzka-Krajewska A., Banaszkiewicz A., Kulus M., Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

|

2015

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tom 63

|

nr 3

9

Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia - induced acute lung injury

84%

Gokcinar D., Ergin V., Cumaoglu A., Menevse A., Aricioglu A.

Acta Biochimica Polonica

|

2013

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tom 60

|

nr 3

Intravenous lipopolysaccharide (LPS) leads to acute lung injury (ALI) in rats. The purpose of this study was to examine the anti-inflammatory and antioxidant efficacy of ketamine, propofol, and ketofol in a rat model of ALI. We induced ALI in rats via intravenous injection of LPS (15 mg kg-1). The animals were randomly separated into five groups: control, LPS only, LPS + ketamine (10 mg·kg-1·h-1), LPS + propofol (10 mg·kg-1·h-1), LPS + ketofol (5 mg·kg-1·h-1 ketamine + 5 mg·kg-1·h-1 propofol). LPS resulted in an increase in the release of pro-inflammatory cytokines, mRNA expression related with inflammation, production of nitric oxide, and lipid peroxidation. Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue. Propofol decreased the levels of cytokines in plasma and lung tissue, whereas it had no effect on the IL-1-beta level in lung tissue. Ketamine downregulated mediators of lung tissue inflammation and reduced the level of circulating cytokines and protected lung tissue against lipid peroxidation. Ketofol decreased the level of TNF-α and IL-1β in plasma, as well as expression of cyclooxygenase-2 mRNA and the nitrate/nitrite level in lung tissue. The results of this investigation support the hypothesis that ketamine may be effective in preventing ALI.

10

Cytotoxicity and proinflammatory cytokine expression in response to eluates of a ceramic-polymer composite biomaterial in cultured human hs-27 cells; possible application for bone regeneration

84%

Zarzecka J., Fraczek J., Skorska-Stania A., Jelonek A., Czopik B., Mycinski P., Wrobel M.

Folia Biologica

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2018

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tom 66

|

nr 4

11

Chronic but not acute antidepressant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice

84%

Mlyniec K., Ostachowicz B., Krakowska A., Reczynski W., Opoka W., Nowak G.

Journal of Physiology and Pharmacology

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2014

|

tom 65

|

nr 5

12

Proinflammatory cytokine changes in bronchoalveolar lavage fluid cells isolated from pigs infected solely with porcine reproductive and respiratory syndrome virus or co-infected with swine influenza virus

84%

Czyzewska-Dors E., Pomorska-Mol M., Dors A., Pluta A., Podgorska K., Kwit K., Stasiak E., Lukomska A.

Journal of Veterinary Research

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2019

|

tom 63

|

nr 4

13

Complement inhibitory proteins expression in placentas of thrombophilic women

84%

Wirstlein P. K., Jasinski P., Rajewski M., Gozdziewicz T., Skrzypczak J.

Folia Histochemica et Cytobiologica

|

2012

|

tom 50

|

nr 3

14

Vaccaria n-butanol extract lower the production of proinflammatory cytokines and the infection risk of T. spiralis in vivo

84%

Xu F., Hou B., Zhu X., Liu Y., Shi X., Li S., Li Z., Cai W., Zhou Y., Qiu L.

Acta Parasitologica

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2019

|

tom 64

|

nr 3

15

Serum endocan level in diabetes mellitus of patients with cirrhosis and risk of subsequent development of spontaneous bacterial peritonitis

84%

Zuwala-Jagiello J., Pazgan-Simon M., Simon K., Kukla M., Murawska-Cialowicz E., Grzebyk E.

Journal of Physiology and Pharmacology

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2019

|

tom 70

|

nr 3

16

Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid [TNBS]-induced colitis

84%

Engel M. A., Kellermann C. A., Burnat G., Hahn E. G., Rau T., Konturek P. C.

Journal of Physiology and Pharmacology

|

2010

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tom 61

|

nr 1

89-97

This study was performed to assess whether mice lacking the cannabinoid receptor CB1, CB2 or both receptors show increased susceptibility to TNBS colitis in comparison to wildtype mice. Previously, activation of CB1 and CB2 receptors showed attenuation of TNBS colitis in mice. The aim of the study was to investigate the susceptibility of three mouse strains CB1-, CB2- and CB1+2 double knockout mice in the model of TNBS colitis. The different knockout mice were given each a single enema with TNBS 7 mg, volume 150 µl (in 50% ethanol solution) on day 1. Control group (C57BL/6 mice) received the same concentration of TNBS enema and each strain received vehicle application of 150 µl 50% ethanol solution. After a 3-day period, the animals were sacrificed and their colon excised. A scoring system was used to describe macroscopical and histological changes. Messenger RNA-expression of TNF- and IL-1ß as pro-inflammatory markers was measured by RT-PCR. All three knockout strains showed increased susceptibility to TNBS colitis quantified by macroscopical and histological scoring systems and pro-inflammatory cytokine expression in comparison to the TNBS control group (wild type C57BL/6 animals). Mice lacking the CB1-, CB2-receptor or both receptors showed aggravation of inflammation in the model of TNBS colitis. Lacking of both cannabinoid receptors did not result in potentiation of colitis severity compared to lacking of each CB1 or CB2, respectively. These results suggest that the endocannabinoid system may have tonic inhibitory effects on inflammatory responses in the colon.

17

Quercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats

84%

Tiboc-Schnell C. N., Filip G. A., Man S. C., Decea N., Moldovan R., Opris R., Sas V., Tabaran F.

Journal of Physiology and Pharmacology

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2020

|

tom 71

|

nr 4

18

Are NKT cells essential for endotoxic shock?

84%

Emoto M.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 4

19

CSF-1 as a regulator of macrophage activation and immune responses

84%

Sweet M. J., Hume D. A.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 3

20

Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa

67%

Zwolinska-Wcislo M., Brzozowski T., Budak A., Kwiecien S., Sliwowski Z., Drozdowicz D., Trojanowska D., Rudnicka-Sosin L., Mach T., Konturek S. J., Pawlik W. W.

Journal of Physiology and Pharmacology

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2009

|

tom 60

|

nr 1

107-118

The influence of fungal colonization on the course of ulcerative colitis (UC) has not been thoroughly studied. We determined the activity of the disease using clinical, endoscopic and histological index (IACH) criteria in UC patients with fungal colonization and the healing process of UC induced by an intrarectal administration of trinitrobenzene sulfonic acid (TNBS) in rats infected with Candida, without and with antifungal (fluconazole) or probiotic (lacidofil) treatment. The intensity of the healing of the colonic lesions was assessed by macro- and microscopic criteria as well as functional alterations in colonic blood flow (CBF). Myeloperoxidase (MPO) content and plasma proinflammatory cytokines IL-1ß and TNF- levels were evaluated. Candida more frequently colonized patients with a history of UC within a 5-year period, when compared with those of shorter duration of IBS. Among Candida strains colonizing intestinal mucosa, Candida albicans was identified in 91% of cases. Significant inhibition of the UC activity index as reflected by clinical, endoscopical and histological criteria was observed in the Candida group treated with fluconazole, when compared to that without antifungal treatment. In the animal model, Candida infection significantly delayed the healing of TNBS-induced UC, decreased the CBF and raised the plasma IL-1ß and TNF- levels, with these effects reversed by fluconazole or lacidofil treatment. We conclude that 1) Candida delays healing of UC in both humans and that induced by TNBS in rats, and 2) antifungal therapy and probiotic treatment during Candida infection could be beneficial in the restoration and healing of colonic damage in UC.

Ograniczanie wyników

Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

Role of monocytes in the pathogenesis of dengue

Proinflammatory cytokines and Helicobacter pylori stimulate C-C chemokine expression in gastric epithelial cells

Contribution of tumor necrosis factor alpha to the pathogenesis of stroke

The effect of estrogen receptor agonists on pancreaticobiliary duct ligation induced experimental acute pancreatitis

Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats

Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis

Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma

Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia - induced acute lung injury

Cytotoxicity and proinflammatory cytokine expression in response to eluates of a ceramic-polymer composite biomaterial in cultured human hs-27 cells; possible application for bone regeneration

Chronic but not acute antidepressant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice

Proinflammatory cytokine changes in bronchoalveolar lavage fluid cells isolated from pigs infected solely with porcine reproductive and respiratory syndrome virus or co-infected with swine influenza virus

Complement inhibitory proteins expression in placentas of thrombophilic women

Vaccaria n-butanol extract lower the production of proinflammatory cytokines and the infection risk of T. spiralis in vivo

Serum endocan level in diabetes mellitus of patients with cirrhosis and risk of subsequent development of spontaneous bacterial peritonitis