Wyniki wyszukiwania

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Study on the role of NO radical in the mechanism of antinociceptive effect of proctolin in rats

100%

Plech A., Konopinska D., Kuczer M., Jakrzewska H., Rykaczewska-Czerwinska M., Maksym B., Radecki Z.

Pestycydy

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2006

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nr 1-2

15-19

2

Studies on central effects of [Lys1]-proctolin an analogue of proctolin (PR)

84%

Jedrusiak J., Plech A., Brus R., Sobotka W., Konopinska D.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 1

3

Chelating ability of proctolin tetrazole analogue

84%

Lodyga-Chruscinska E., Sanna D., Micera G., Chruscinski L., Olejnik J., Nachman R. J., Zabrocki J.

Acta Biochimica Polonica

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2006

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tom 53

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nr 1

The aim of the investigation was to establish the chelating ability of a new proctolin analogue of the sequence Arg-Tyr-LeuΨ[CN4]Ala-Thr towards copper(II) ions. The insertion of the tetrazole moiety into the peptide sequence has considerably changed the coordination ability of the ligand. Potentiometric and spectroscopic (UV-Vis, CD, EPR) results indicate that the incorporation of 1,5-disubstituted tetrazole ring favours the formation of a stable complex form of CuH-1L. This 4N coordination type complex is the dominant species in the physiological pH range. The tetrazole moiety provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside the peptide backbone. These findings suggest that Cu(II) can hold peptide chains in a bent conformation. This bent conformation may be essential for bioactivity of the tetrazole peptides.

4

Biological evaluation of analogues of an insect neuropeptide proctolin

84%

Woznica I., Szeszel-Fedorowicz W., Rosinski G., Konopinska D.

Acta Biochimica Polonica

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2004

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tom 51

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nr 1

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

5

Proctolin's role as a releasing factor in the corpus cardiacum-corpus allatum of the locust

67%

Clark L., Lange A. B.

Pestycydy

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2005

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nr 4

71-76

6

Peptidergic innervation of the excurrent ostia of two orthopteroid insects

67%

Lange A. B., Da Silva R.

Pestycydy

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2007

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nr 3-4

11-16

The dorsal vessels of two Orthopteroid insects, the African migratory locust, Locusta migratoria, and the Vietnamese stick insect, Baculum extradentatum, were examined for their morphology. The dorsal vessels of both of these species consist of a tubular heart and an aorta that extends anteriorly into the head. Alary muscles, associated with the hearts, are anchored to the body wall with attachments to the dorsal diaphragm. Alary muscle contraction draws haemolymph into the heart through incurrent ostia. Excurrent ostia are present in both species with 7 pairs in the locust and 3 pairs in the stick insect. Each excurrent ostium is made up of a mass of cells that produce openings or slits that allow the haemolymph to exit the heart and enter the perivisceral cavity directly without traveling through the aorta. Muscle fibers are associated with the excurrent ostia and these receive innervation from nerve processes containing proctolin-like immunoreactivity. These data indicate that the excurrent ostia are most likely under modulation from neuropeptides that might result in microcirculatory changes in these insects.

7

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Antinociceptive effect of MAS MT in rats

67%

Rykaczewska-Czerwinska M., Radosz A., Szymanowska-Dziubasik K., Konopinska D., Plech A.

Pestycydy

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2008

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nr 3-4

139-146

MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.

8

Neuropeptides and insect heartbeat: the myth and reality

67%

Slama K.

Pestycydy

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2005

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nr 3

95-107

Ograniczanie wyników

Study on the role of NO radical in the mechanism of antinociceptive effect of proctolin in rats

Studies on central effects of [Lys1]-proctolin an analogue of proctolin (PR)

Chelating ability of proctolin tetrazole analogue

Biological evaluation of analogues of an insect neuropeptide proctolin

Proctolin's role as a releasing factor in the corpus cardiacum-corpus allatum of the locust

Peptidergic innervation of the excurrent ostia of two orthopteroid insects

Antinociceptive effect of MAS MT in rats

Neuropeptides and insect heartbeat: the myth and reality