Wyniki wyszukiwania - AGRO

1

The animal model of acute pancreatitis induced by synthetic prooxidant

100%

Sledzinski Z., Wozniak M., Brunelli A., Scutti G., Stanek A., Bertoli E., Lezoche E., Wajda Z.

Polish Journal of Environmental Studies

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1998

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tom 07

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nr 6

2

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Experimental infection of sheep with bovine immunodeficiency virus

100%

Bicka L., Rola M., Kuzmak J.

Bulletin of the Veterinary Institute in Puławy

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2000

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tom 44

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nr 1

Five sheep were experimentally infected with bovine immunodeficiency virus (BIV). All animals seroconverted to BIV p26 core protein by 6 weeks after inoculation and developed persistent lymphocytosis. Proviral DNA has been continually detected only in one sheep and temporarily present in other two animals. All attempts to rescue the BIV from peripheral blood leukocytes of uninfected sheep have failed during experiment. The established model of bovine lentivirus infection in sheep provides valuable data to examine the pathogenesis of BIV and related retroviral infections.

3

The role of reactive oxygen spesies in the pathogenesis of experimental maxillary sinusitis

88%

Andreychyn Y.

Health Problems of Civilization

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2014

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tom 08

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nr 4

Simulated maxillary sinusitis was observed in guinea pigs following the surgical incision in superior cervical sympathetic ganglion. Additionally, toxic hepatitis development was stimulated after exposure to tetrachlormethane in experimental animals. The treated and control animals were observed for three months. A significant increase in the content of reactive oxygen species (ROS) in neutrophils and lymphocytes was noted in artificially developed sinusitis. The ROS values were slightly higher in the case of combined experimental sinusitis and toxic hepatitis. Based on the obtained data, the role of ROS in the development of sinusitis was discussed.

4

A link between the COVID-19 pandemic and Kawasaki-like multi-system inflammatory syndrome in children

88%

Elshamaa M. F.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

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nr 4

5

Melanotic neuroectodermal tumour in infancy – Case Report

88%

Haberko P., Lewandowski B., Brodowski R., Chrzanowska-Kler E., Osuchowski M., Zych B., Migut M.

Journal of Pre-Clinical and Clinical Research

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2021

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tom 15

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nr 1

6

Central serous chorioretinopathy induced by drugs metabolized by cytochrome P450 3A4

88%

Morawski K., Klonowska A., Kubicka-Trzaska A., Woron J., Romanowska-Dixon B.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 2

7

p53 and p16 alterations in lung cancer

88%

Niklinski J., Chyczewski L., Niklinska W.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

8

Central and peripheral neural aspects of gastroprotective and ulcer healing effects of lipopolysaccharides

88%

Konturek P. C., Brzozowski T., Meixner H., Ptak A., Hahn E. G., Konturek S. J.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 4,1

Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-- negative bacteria playing a central role as potent endotoxins in the pathogenesis of endotoxic shock. Although large amounts of endotoxin may produce hemorrhagic lesions in the stomach, the possible gastroprotective effect of central or peripheral LPS against the acute gastric lesions has not been extensively studied. The aim of the present study was to compare the effect of intracerebroventricular (i.c.v.) and parenteral (i.p.) injection of LPS against gastric lesions induced by 100% ethanol. Male Wistar rats were treated either with a) vehicle (control); b) E-coli-LPS in various concentrations (1—10 µg/kg i.c.v or 0.1—40 mg/kg i.p.) followed 30 min later by 100% ethanol. The effects of pretreatment with nonselective inhibitor of nitric oxide synthase (L-NAME, 20 mg/kg i.g.) or selective inhibitor of inducible nitric oxide synthase, L-NIL (30 mg/kg i.g) on the gastroprotection induced by LPS was investigated. One hour after ethanol application, the gastric blood flow (GBF) and the area of gastric lesions were determined. In addition, the mucosal expression of iNOS, cNOS and leptin was assessed using RT-PCR. LPS applied i.c.v. or i.p. dose dependently reduced gastric lesions induced by ethanol and this effect was similar to that observed after the administration of NO donor (SNAP). LPS-induced protection was significantly abolished by L-NAME and significantly attenuated by the selective inhibitor of iNOS (L-NIL). The expression of cNOS was detected in vehicle treated gastric mucosa and did not change after LPS administration. iNOS was not detectable in intact mucosa but its expression dose-dependently increased after the LPS administration. The i.c.v. administration of LPS did not upregulate further the iNOS expression, and dose-dependently inhibited the leptin mRNA expression in gastric mucosa. We conclude that LPS applied centrally or peripherally protects gastric mucosa against ethanol-induced damage through an increase in gastric microcirculation mediated by NO due to overexpression of iNOS. Transcriptional downregulation of leptin in gastric mucosa is probably due to the increased leptin release induced by the intracerebroventricular application of lipopolysaccharide.

9

Identification of acidic and basic forms of pathogenesis-related [PR] proteins in potato leaves infected with potato virus Y

88%

Marczewski W.

Phytopathologia Polonica

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1994

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tom 08

10

Configuration of the ureteral orifice in children - a morphometric analysis

88%

Galazkiewicz M., Makosiej R., Orkisz S., Zwierzchowska A.

Acta Biologica Cracoviensia. Series Botanica et Zoologia. Supplement

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1997

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tom 39

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nr 1

11

The function of interleukin 17 in the pathogenesis of rheumatoid arthritis

88%

Paradowska A., Maslinski W., Grzybowska-Kowalczyk A., Lacki J.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

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nr 5

12

Canine degenerative myelopathy – pathogenesis, current diagnostics possibilities and breeding implications regarding genetic testing

75%

Fiszdon K., Gruszczynska J., Siewruk K.

Acta Scientiarum Polonorum. Zootechnica

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2020

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tom 19

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nr 1

13

Modern aspects on Shigella pathogenecity and vaccine development - a review

75%

Pal P.

International Letters of Natural Sciences

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2014

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tom 12

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nr 1

Shigella species are intracytosolic Gram-negative invasive enteropathogenic bacteria, causing the rupture, invasion and inflammatory destruction of the human colonic epithelium. They utilize the host cytoskeletal components to form propulsive actin tails. The so-called invasive phenotype of Shigella is linked to expression of a type III secretory system (TTSS) injecting effector proteins into the epithelial cell membrane and cytoplasm, thereby inducing local but massive changes in the cell cytoskeleton that lead to bacterial internalization into non-phagocytic intestinal epithelial cells. The molecular and cellular bases of this invasive phenotype essentially encompass crossing of the epithelial lining, apoptotic killing of macrophages, entry into epithelial cells, and escape into the cytoplasm, followed by cell-to-cell spread. Intracellular colonization is likely to protect the micro-organisms from killing by humoral and cellular effectors of the innate immune response. Concurrently, the capacity of Shigella to reprogram invaded epithelial cells to produce proinflammatory mediators plays a major role in the strong inflammatory profile of the disease. This profile is likely to impact on the nature and quality of the adaptive response, which is dominated by humoral protection at the mucosal level. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine.

14

Decreased expression of p73 in colorectal cancer

75%

Kotulak A., Wronska A., Kobiela J., Godlewski J., Stanislawowski M., Wierzbicki P.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 3

15

Dizziness - pathogenesis, diagnosis and treatment

75%

Tomaszewski M., Banakiewicz K., Jajko K., Szypowski R., Zielinski P., Zalewski G., Olchowik G.

Health Problems of Civilization

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2015

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tom 09

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nr 1

Dizziness is a symptom of many diseases. Patients very frequently come with such ailment to the hospital emergency department. It is a state which may last a few seconds or minutes and increase or recede with time. Therefore, the admitted patients frequently cannot assess their own illness in a precise and objective way. The dizziness definition is also quite ambiguous. Dizziness is defined as the sensation of one own’s body movement or spinning and movement of the surrounding. It is very important to record the patient’s medical history since the diagnostic procedure may depend on the symptoms’ character. Dizziness may be a symptom of a serious disease, although it is not easy to find its cause. It appears not only in case of the labyrinth and nervous system disorders, but also in the systemic and functional diseases. Dizziness and balance disorder are the direct cause of admitting one in every thirty patients. The symptom indicated the directly life-threatening disease only within the 3-8.5% of patients (cerebral circulation insufficiency - 6%, cardiac dysrhythmia – 1.5%, brain tumour < 1%). Analyzing the data concerning the problem of dizziness occurrence within the general population, it has been noticed that this symptom has been reported two or three times more frequent by women than by men. Dizzinesses are classified pathogenetically and clinically into labyrinthine and non-labyrinthine, paroxysmal and permanent, acute and chronic. Dizziness is hard to diagnose because the symptoms reported by patients are only their own subjective sensations. The data presented in the article implicate the increasing number of patients with such disorders. Apart from dizziness, the patients complain also about the hearing disorders and nausea, which make their proper functioning impossible. It is inappropriate to start the treatment without knowing the cause. Establishing, on the basis of patient’s medical history and physical examination, whether the dizziness is of peripheral or central origin, is essential for the further diagnosis. After establishing the main diagnosis, the casual and symptomatic treatment is implemented, in some cases - there is a vestibular rehabilitation or even a surgical treatment.

16

Structural analyses of Shigella invasion proteins reveals non-conserved; intrinsically unstructured regions

75%

Chakrabarti S., Ganguli S.

International Letters of Natural Sciences

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2013

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tom 05

Shigella is one of the most common bacterial pathogens that are isolated from patients with diarrhea. Various attempts are being made worldwide with encouraging observations; still the emergence of multidrug-resistant Shigella strains and a continuous high disease incidence imply that shigellosis is an unsolved global health problem which can probably be solved only by developing a proper vaccine and a vaccine regime for the disease. The need of the hour is to foster the development of an effective vaccine which should not only serve to improve hygiene but also should be able to curb infections by the pathogen. This goal can only be achieved by gaining proper detailed knowledge underlying Shigella pathogenesis. The analyses of the Shigella invasion proteins which have been long been targeted to be potential candidate vaccines remains an open ended problem and forms the core of this present computational study which identifies the fact that long regions in the structure of the proteins are disordered having no distinct structural conformation; multiple alignments however, did not show any conserved stretches in the disordered regions. The results probably explain the ability of these proteins to interact with multiple cellular proteins and perform a diverse array of functions leading to successful pathogenesis.

17

Treatment of inflammatory bowel disease (IBD) in dogs and cats

75%

Malewska K., Rychlik A., Nieradka R., Kander M.

Polish Journal of Veterinary Sciences

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2011

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tom 14

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nr 1

The treatment of inflammatory bowel disease (IBD) possesses numerous difficulties owing to the unclear etiology of the disease. This article overviews the drugs used in the treatment of IBD depending on the intensity of clinical symptoms (Canine Inflammatory Bowel Disease Activity Index and Canine Chronic Enterophaty Clinical Activity Index). Patients demonstrating mild symptoms of the disease are usually placed on an appropriate diet which may be combined with immunomodulative or probiotic treatment. In moderate progression of IBD, 5-aminosalicylic acid (mesalazine or olsalazine) derivatives may be administered. Patients showing severe symptoms of the disease are usually treated with immunosuppressive drugs, antibiotics and elimination diet. Since the immune system plays an important role in the pathogenesis of the disease, the advancements in biological therapy research will contribute to the progress in the treatment of canine and feline IBD in the coming years.

18

Indications to epigenetic dysfunction in the pathogenesis of common variable immunodeficiency

75%

Rae W.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 2

19

Dependence of callus regeneration potency on the structure and presence of the suspensor of lettuce parthenogenetic proembryos cultured in vitro

75%

Piosik L., Zenkteler M., Zenkteler E.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 1

20

Role of monocytes in the pathogenesis of dengue

75%

Castillo J. A., Naranjo J. S., Rojas M., Castano D., Velilla P. A.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

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nr 1

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