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1
Content available remote

Interleukin-6 deficiency modifies the effect of high fat diet on myocardial expression of fatty acid transporters and myocardial lipids

100%
Mysliwiec P., Choromanska B., Winnicka M. M., Kaminski K., Mysliwiec H., Dadan J., Supruniuk E., Chabowski A.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 4
2
Content available remote

The influence of the low-energy defibrillating impulse on the endothelin-1 concentration in the left heart ventricle and blood serum of the healthy rabbits

100%
Zurawinski W., Kokot T., Swietochowska E., Sosada K., Muc-Wierzgon M.
Journal of Physiology and Pharmacology
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2019
|
tom 70
|
nr 1
3
Content available remote

The association between serum galectin-3 level and its placental production in patients with preeclampsia

100%
Pankiewicz K., Szczerba E., Fijalkowska A., Szamotulska K., Szewczyk G., Issat T., Maciejewski T. M.
Journal of Physiology and Pharmacology
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2020
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tom 71
|
nr 6
4

The effect of oxidative damage on ATP level in heat stressed endothelial cells

100%
Gray C. C., Smolenski R. T., Amrani M., Taylor G., Yacoub M. H.
Cellular and Molecular Biology Letters
|
1999
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tom 04
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nr 3
5
Content available remote

Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart

80%
Goraca A., Piechota A., Huk-Kolega H.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 1
61-68
Lipopolysaccharide (LPS) is a gram-negative bacterial endotoxin and a major factor that contributes to multiple organ failure, including heart injury. Myocardial dysfunction in septic shock depends on the presence of proinflammatory cytokines and reactive oxygen/nitrogen species. In this study, the effect of early administration of an antioxidant, -lipoic acid (LA) on lipid peroxidation, hydrogen peroxide (H2O2), sulphydryl groups (-SH groups) and total protein concentration and the glutathione redox system was evaluated in the heart homogenates obtained from LPS-induced endotoxic shock rats (Escherichia coli 026:B6, 30 mg/kg, i.v.). The animals were treated intravenously with saline or LA (60 mg/kg or 100 mg/kg i.v.) 30 min after LPS injection. Five hours after LPS, LA or saline administration, the animals were sacrificed and their hearts were isolated for measurements. Injection of LPS alone resulted in the development of shock and oxidative stress that was indicated by a significant increase in thiobarbituric acid reactive substances (TBARS) and H2O2 concentrations, a decrease in concentration of -SH groups and reduced glutathione, and by decrease in glutathione redox ratio reduced glutathione (GSH)/oxidized glutathione (GSSG) in the heart. Administration of LA after the LPS challenge resulted in an increase in the sulfhydryl group content and a decrease in TBARS and H202 concentrations in the heart as compared with the LPS group. In addition, the treatment of LA after LPS challenge significantly decreased the level of GSSG, increased the level of GSH in heart homogenates resulting in an increase of the GSH/GSSG ratio compared with the LPS group. There was no difference in oxidative stress reduction between 60 mg/kg and 100 mg/kg doses. These results indicate that early administration of LA is highly effective in dampening endotoxin-induced oxidative stress in the heart and in improving the glutathione redox system. This study supports the idea that -LA is a free radical scavenger and a potent antioxidant.
6

Echocardiographic evaluation of diastolic parameters in dogs with dilated cardiomyopathy

80%
Garncarz M. A.
Polish Journal of Veterinary Sciences
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2007
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tom 10
|
nr 4
Echocardiography is a valuable tool for the evaluation of systolic and diastolic cardiac function. A high correlation between measurements of diastolic mitral inflow parameters analyzed with Doppler echocardiography and invasive methods makes the former valuable. The aim of this study was to ascertain if significant differences occur in diastolic myocardial parameters between dogs with no heart disease and dogs with subclinical or clinical dilated cardiomyopathy. Furthermore the aim of the study was to determine whether heart failure in dilated cardiomypathy is a result of systolic dysfunction alone or both systolic and diastolic dysfunction. Eleven parameters were analyzed: E wave, E-AT, E-DT, E time, A wave, A-AT, A-DT, A time, E+A time, E/A ratio, and IVRT. The study confirmed the value of noninvasive echocardiographic assessment of diastolic function in dogs with dilated cardiomyopathy. Significant differences were found in E wave, E-AT, E time, E/A ratio and IVRT between healthy dogs and dogs with dilated cardiomyopathy. All are characterized by a significant decrease compared to healthy dogs after taking into account age and body weight except for the E/A ratio, which significantly increased in value. There were no significant changes in any of the Doppler parameters for diastolic evaluation in subclinical cases of DCM. Advanced heart failure in dilated cardiomyopathy entails systolic and diastolic dysfunction.
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