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  1. 6 Folia Histochemica et Cytobiologica

  2. 3 Archivum Immunologiae et Therapiae Experimentalis

  3. 2 Cellular and Molecular Biology Letters

  4. 2 Folia Biologica

  5. 2 Journal of Physiology and Pharmacology. Supplement

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  1. 4 Kurpisz M.

  2. 4 Rozwadowska N.

  3. 2 Grabowska I.

  4. 2 Grzelkowska-Kowalczyk K.

  5. 2 Jank M.

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  1. 2 2018

  2. 1 2016

  3. 1 2015

  4. 1 2014

  5. 2 2012

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1

Stimulation of myogenesis by 2,2'-thiodiethanol in suboptimal tissue culture conditions

100%
Reiss K., Pietrzykowski Z., Kajstura J., Korohoda W.
Folia Histochemica et Cytobiologica
|
1985
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tom 23
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nr 3
2
Content available remote

Transforming growth factor-beta1 upregulates myostatin expression in mouse C2C12 myoblasts

86%
Budasz-Swiderska M., Jank M., Motyl T.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 3
195-214
Myostatin (MSTN) and transforming growth factor-ß1 (TGF-ß1) belong to the same TGF-ß superfamily of proteins. They are involved in regulation of skeletal muscle growth and development as well as muscle catabolism. The aim of the present study was to investigate the relationship between mstn and TGF-ß1 expression in proliferating and differentiating mouse C2C12 myoblasts cultured in normal and catabolic conditions and to evaluate the effect of exogenous TGF-ß1 as well as "knock down" of TGF-ß1 receptor type II on mstn expression in proliferating and differentiating myogenic cells. The direct effect of TGF-ß1 on myostatin was also examined. Myostatin expression increased gradually with cell confluency in proliferating cultures, while the level of TGF-ß1, detected in the form of a 100 kDa small latent complex diminished. Myostatin expression was accompanied by a partial cell cycle arrest. Three forms of myostatin were found: a 52 kDa precursor, a 40 kDa latency associated propeptide, and a 26 kDa active peptide. A decrease in myostatin and TGF-ß1 levels was observed during the first three days of differentiation, which was subsequently followed by significant increase of their expression during next three to four days of differentiation. Catabolic state induced by dexamethasone significantly increased the level of all forms of myostatin as well as latent (100 kDa) and active (25 kDa) forms of TGF-ß1 in differentiating myoblasts in a dose dependent manner. Exogenous TGF-ß1 (2 ng/ml) significantly increased myostatin levels both in proliferating and differentiating C2C12 myoblasts, whereas silencing of the TGF-ß1 receptor II gene significantly lowered myostatin level in examined cells. The presented results indicate that TGF-ß1 may control myostatin-related regulation of myogenesis through up-regulation of myostatin, predominantly in the course of terminal differentiation and glucocorticoid-dependent catabolic stimulation.
3

The role of tyrosine kinase in the adhesion and fusion of myoblasts

86%
Wrobel E., Moraczewski J.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
4

Comparison of chromosome centromere topology in differentiating cells with myogenic potential

72%
Mikolajczak B., Wiland E., Rozwadowska N., Rucinski M., Mietkiewski T., Kurpisz M.
Folia Histochemica et Cytobiologica
|
2009
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tom 47
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nr 3
5

Biological and pro-angiogenic properties of genetically modified human primary myoblasts overexpressing placental growth factor in in vitro and in vivo studies

72%
Zimna A., Wiernicki B., Kolanowski T., Rozwadowska N., Malcher A., Labedz W., Trzeciak T., Chojnacka K., Bednarek-Rajewska K., Majewski P., Kurpisz M.
Archivum Immunologiae et Therapiae Experimentalis
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2018
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tom 66
|
nr 2
6

Insulin-like growth factor-I increases laminin, integrin subunits and metalloprotease ADAM12 in mouse myoblasts

72%
Grzelkowska-Kowalczyk K., Grabiec K., Tokarska J., Gajewska M., Blaszczyk M., Milewska M.
Folia Biologica
|
2015
|
tom 63
|
nr 4
7
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Content available

Transcriptional pattern of TGF-beta1 inhibitory effect on mouse C2C12 myoblasts differentiation

72%
Wicik Z., Sadkowski T., Jank M., Motyl T.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 4
The aim of the present study was to define the effect of TGF-β1 on C2C12 myoblasts myogenesis. TGF-β1 together with its receptor is a negative auto-paracrine regulator of myogenesis, which influences the proliferation, differentiation, and functions of muscle cells. TGF-β1 exerts highly significant inhibitory effect on differentiation of C2C12 mouse myoblasts manifested by the impairment of cell fusion and very low expression of myosin heavy chain. The study of differentiating C2C12 mouse myoblasts treated with TGF-β1 revealed 502 genes (436 down-regulated and 66 up-regulated) with statistically different expression. TGF-β1-regulated genes were identified to be involved in 29 biological processes, 29 molecular functions groups and 59 pathways. The strongest inhibiting effect of TGF-β1 was observed in the cadherin and Wnt pathways. The key-genes that could play the role of TGF-β1 targets during myoblasts differentiation was identified such as: Max, Creb1, Ccna2, Bax, MdfI, Tef, Tubg1, Cxcl5, Rho, Calca and Lgals4.
8
Content available remote

The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes

72%
Bar-Shai M., Hasnis E., Wiener-Megnazi Z., Reznick A. Z.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
39-44
Using the electromobility shift assay (EMSA) in the rat myoblast system, the activation of transcription factor NF-B by reactive nitrogen species was evaluated. Two distinct patterns of activation were demonstrated. Whereas NO donor, SNAP, activated NF-B in the classical pathway, which led to a transient response, NF-B activation by peroxynitrite donor, SIN-1, was mediated by an alternative pathway, which has been demonstrated in previous works to involve tyrosine nitration of the NF-B inhibitory protein I-Balpha. This led to a constitutive non-transient activation of NF-B and a prolonged inflammatory reaction. Lymphocytes exposed to mild intensity of cigarette smoke for 8 h, which activated NF-B, exhibited a decrease in the fraction of apoptotic cells from 27% to 19% compared with lymphocytes exposed to atmospheric air, using the FACS Annexin V assay. This also has been shown in previous works to be mediated by peroxynitrite. Thus, mild exposure to cigarette smoke induces NF-B activation, which can attenuate apoptosis in human lymphocytes and lead to prolonged inflammatory response. A possible proposed mechanism for induction of chronic inflammatory response may involve peroxynitrite-induced activation of NF-B.
9

Talin, vinculin and nestin expression in orofacial muscles of dystrophin deficient mdx mice

72%
Spassov A., Gredes T., Pavlovic D., Gedrange T., Lehmann C., Lucke S., Kunert-Keil C.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
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tom 60
|
nr 2
10

In vitro culture of primary human myoblasts by using the dextran microcarriers Cytodex3

72%
Rozwadowska N., Malcher A., Baumann E., Kolanowski T. J., Rucinski M., Mietkiewski T., Fiedorowicz K., Kurpisz M.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 2
11

Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action

72%
Lewicki S., Lewicka A., Kalicki B., Sobolewska-Ruta A., Debski B., Zdanowski R., Syrylo T., Kloc M., Kubiak J. Z.
Folia Histochemica et Cytobiologica
|
2018
|
tom 56
|
nr 3
12

Syndecan-4 distribution during the differentiation of satellite cells isolated from soleus muscle treated by phorbol ester and calphostin C

72%
Brzoska E., Grabowska I., Wrobel E., Moraczewski J.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 2
It was shown that syndecans have a potential role in muscle development. We focused this study on the role of syndecan-4 distribution and phosphorylation during the differentiation of satellite cells isolated from Soleus muscle. Syndecans are cell surface heparan sulfate proteoglycans (HSPGs) that bind numerous ligands through their HS glycosaminoglycan chains (GAG). They play a role in cell-extracellular matrix and cell-cell adhesion, signal transduction and the targeting of growth factors and other molecules to the cell surface. Syndecan-4 acts as a co-receptor or, along with integrins, is localized to the cell membrane of focal contacts. Syndecan-4 participates in the organization of the structure of focal contacts reacting with extracellular matrix molecules. The interaction of syndecan-4 with protein kinase C (PKC) isoforms is the main mechanism regulating its distribution in cells. Our current study focused on the role of the distribution of syndecan-4, and its interactions with PKC isoforms during the differentiation of activated satellite cells. We used the PKC activator TPA (12-O-tetradecanoyl phorbol 13-acetate) and the PKC inhibitor Calphostin C (Cal C). We concluded that syndecan-4 was important not only in the activation of satellite cells, but also in myoblast differentiation. During our research, we observed the presence of syndecan-4 and changes in its location over the course of that process. We also showed that TPA and Cal C treatment had an influence on the subcellular distribution of syndecan-4, but there was no influence on myoblast differentiation. We speculated that the reason for changes after TPA treatment was the interactions with activated PKCα, which provoked syndecan-4/PKCα complex translocation to integrins. We also supposed that Cal C treatment inhibited PKCδ activity and probably induced PKCα association to syndecan-4, and syndecan-4 translocation to integrins.
13

The impairment of IGF-I-stimulated protein synthesis and activation of protein kinase B, p70S6k, MAP kinase, and p90rsk in mouse C2C12 myogenic cells exposed to high glucose and high insulin

58%
Grzelkowska-Kowalczyk K., Wieteska W.
Polish Journal of Veterinary Sciences
|
2005
|
tom 08
|
nr 3
14

Implant of polymer containing pentacyclic triterpenes from Eugenia punicifolia inhibits inflammation and activates skeletal muscle remodeling

58%
Leite P. E. C., Lima-Araujo K. G., Franca G. R., Lagrota-Candido J., Santos W. C., Quirico-Santos T.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
|
tom 62
|
nr 6
15
Content available remote

Transient and stable transfections of mouse myoblasts with genes coding for pro-angiogenic factors

58%
Bialas M., Krupka M., Janeczek A., Rozwadowska N., Fraczek M., Kotlinowski J., Kucharzewska P., Lackowska B., Kurpisz M.
Journal of Physiology and Pharmacology
|
2011
|
tom 62
|
nr 2
Cardiomyocyte loss in the ischaemic heart can be the reason of many complications, eventually being even the cause of patient's death. Despite many promises, cell therapy with the use of skeletal muscle stem cells (SMSC) still remains to be modified and improved. Combined cell and gene therapy seems to be a promising strategy to heal damaged myocardium. In the present study we have investigated the influence of a simultaneous overexpression of two potent pro-angiogenic genes encoding the fibroblast growth factor-4 (FGF-4) and the vascular endothelial growth factor-A (VEGF-A) on a myogenic murine C2C12 cell line. We have demonstrated in in vitro conditions that myoblasts which overexpressed these factors exhibited significant changes in the cell cycle and pro-angiogenic potential with only slight differences in the expression of the myogenic genes. There was not observed the influence of transient or stable overexpression of FGF-4 and VEGF on cell apoptosis/necrosis in standard or oxidative stress conditions comparing to non transfected controls. Overall, our results suggest that the possible transplantation of myoblasts overexpressing pro-angiogenic factors may potentially improve the functionality of the injured myocardium although the definite proof must originate from in situ conducted pre-clinical studies.
16

Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury

58%
Czerwinska A. M., Streminska W., Ciemerych M. A., Grabowska I.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 1
17

Myogenesis – possibilities of its stimulation in chickens

58%
Sobolewska A., Elminowska-Wenda G., Bogucka J., Szpinda M., Walasik K., Bednarczyk M., Paruszewska-Achtel M.
Folia Biologica
|
2011
|
tom 59
|
nr 3-4
18

Chloramphenicol, an inhibitor of mitochondrial protein synthesis, inhibits myoblast fusion and myotube differentiation

58%
Korohoda W., Pietrzkowski Z., Reiss K.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 1
19

Myonuclear accretion - a brief review

58%
Mozdziak P. E., Giamario C., Petitte J. N.
Animal Science Papers and Reports. Supplement
|
2003
|
tom 21
|
nr 1
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