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  1. 16 Folia Histochemica et Cytobiologica

  2. 14 Archivum Immunologiae et Therapiae Experimentalis

  3. 8 Cellular and Molecular Biology Letters

  4. 3 Acta Neurobiologiae Experimentalis

  5. 3 Journal of Physiology and Pharmacology

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  1. 3 Drewa T.

  2. 3 Majka M.

  3. 2 Bodnar M.

  4. 2 Chen L.

  5. 2 Chen X.

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  1. 4 2021

  2. 1 2020

  3. 3 2019

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1

miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells

100%
Shaer A., Azarpira N., Vahdati A., Karimi M. H., Shariati M.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 3
This paper focuses on the development of renewable sources of isletreplacement tissue for the treatment of type I diabetes mellitus. Placental tissue-derived mesenchymal stem cells (MSCs) are a promising source for regenerative medicine due to their plasticity and easy availability. They have the potential to differentiate into insulin-producing cells. miR-375 is a micro RNA that is expressed in the pancreas and involved in islet development. Human placental decidua basalis MSCs (PDB-MSCs) were cultured from full-term human placenta. The immunophenotype of the isolated cells was checked for CD90, CD105, CD44, CD133 and CD34 markers. The MSCs (P3) were chemically transfected with hsa-miR-375. Total RNA was extracted 4 and 6 days after transfection. The expressions of insulin, NGN3, GLUT2, PAX4, PAX6, KIR6.2, NKX6.1, PDX1, and glucagon genes were evaluated using real-time qPCR. On day 6, we tested the potency of the clusters in response to the high glucose challenge and assessed the presence of insulin and NGN3 proteins via immunocytochemistry. Flow cytometry analysis confirmed that more than 90% of the cells were positive for CD90, CD105 and CD44 and negative for CD133 and CD34. Morphological changes were followed from day 2. Cell clusters formed during day 6. Insulin-producing clusters showed a deep red color with DTZ. The expression of pancreatic-specific transcription factors increased remarkably during the four days after transfection and significantly increased on day 7. The clusters were positive for insulin and NGN3 proteins, and C-peptide and insulin secretion increased in response to changes in the glucose concentration (2.8 mM and 16.7 mM). In conclusion, the MSCs could be programmed into functional insulin-producing cells by transfection of miR-375.
2

Distinct VEGF functions during bone development and homeostasis

86%
Liu Y., Olsen B. R.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
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tom 62
|
nr 5
3

Comparison of gene expression of mitogenic kinin path in adherent and non-adherent CD 34-stem cells using oligonucleotide microarrays

86%
Stojko R., Witek A., Glogowska J., Mazurek U., Chromy G., Wilk K., Witek L., Bojdys-Szyndlar M., Machaj K., Pojda Z.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 1
45-50
4

SDF-1/CXCR4 axis promotes osteogenic differentiation of BMSCs through the JAK2/STAT3 pathway

86%
Xiong W., Guo X., Cai X.
Folia Histochemica et Cytobiologica
|
2021
|
tom 59
|
nr 3
5

The feasibility of the CD271+ and CD271– mesenchymal stromal cell enrichment toward nucleus pulposus-like cells

86%
Jezierska-Wozniak K., Barczewska M., Habich A., Wojtacha P., Badowska W., Maksymowicz W., Wojtkiewicz J.
Folia Histochemica et Cytobiologica
|
2017
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tom 55
|
nr 3
6

Stem cells and metformin synergistically promote healing in experimentally induced cutaneous wound injury in diabetic rats

86%
Shawky L. M., El Bana E. A., Morsi A. A.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 3
7

Heterogeneous populations of bone marrow stem cells - are we spotting on the same cells from the different angles?

86%
Ratajczak M. Z., Kucia M., Majka M., Reca R., Ratajczak J.
Folia Histochemica et Cytobiologica
|
2004
|
tom 42
|
nr 3
8

Do mesenchymal stem cells modulate the milieu of reconstructed bladder wall?

72%
Pokrywczynska M., Jundzill A., Bodnar M., Adamowicz J., Tworkiewicz J., Szylberg L., Debski R., Marszalek A., Drewa T.
Archivum Immunologiae et Therapiae Experimentalis
|
2013
|
tom 61
|
nr 6
9

Mesenchymal stromal cell therapy in MDR/XDR tuberculosis: a concise review

72%
Joshi L., Chelluri L. K., Gaddam S.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
|
tom 63
|
nr 6
10

Astragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells

72%
She Y., Zhao X., Wu P., Xue L., Liu Z., Zhu M., Yang J., Li Y.
Folia Histochemica et Cytobiologica
|
2021
|
tom 59
|
nr 2
11

The differentiation of human placenta-derived mesenchymal stem cells into dopaminergic cells in vitro

72%
Chen L., He D.-M., Zhang Y.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 3
528-536
Mesenchymal stem cells (MSCs) constitute an interesting cellular source to promote brain regeneration after Parkinson’s disease. MSCs have significant advantages over other stem cell types, and greater potential for immediate clinical application. The aim of this study was to investigate whether MSCs from the human placenta could be induced to differentiate into dopaminergic cells. MSCs from the human placenta were isolated by digestion and density gradient fractionation, and their cell surface glycoproteins were analyzed by flow cytometry. These MSCs were cultured under conditions promoting differetiation into adipocytes and osteoblasts. Using a cocktail that includes basic fibroblast growth factor (bFGF), all trans retinoic acid (RA), ascorbic acid (AA) and 3-isobutyl-1-methylxanthine (IBMX), the MSCs were induced in vitro to become dopamine (DA) neurons. Then, the expression of the mRNA for the Nestin and tyrosine hydroxylase (TH) genes was assayed via RT-PCR. The expression of the Nestin, dopamine transporter (DAT), neuronal nuclear protein (NeuN) and TH proteins was determined via immunofluorescence. The synthesized and secreted DA was determined via ELISA. We found that MSCs from the human placenta exhibited a fibroblastoid morphology. Flow cytometric analyses showed that the MSCs were positive for CD44 and CD29, and negative for CD34, CD45, CD106 and HLA-DR. Moreover, they could be induced into adipocytes and osteocytes. When the MSCs were induced with bFGF, RA, AA and IBMX, they showed a change in morphology to that of neuronal-like cells. The induced cells expressed Nestin and TH mRNA, and the Nestin, DAT, NeuN and TH proteins, and synthesized and secreted DA. Our results suggest that MSCs from the human placenta have the ability to differentiate into dopaminergic cells.
12

Pancreatic beta-cell replacement: advances in protocols used for differentiation of pancreatic progenitors to beta-like cells

72%
Ghani M. W., Ye L., Yi Z., Ghani H., Birmani M. W., Nawab A., Cun L. G., Bin L., Mei X.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 3
13

The transplantation of mesenchymal stem cells derived from unconventional sources: an innovative approach to multiple sclerosis therapy

72%
Giacoppo S., Bramanti P., Mazzon E.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 5
14

Muscle stem/progenitor cells and mesenchymal stem cells of bone marrow origin for skeletal muscle regeneration in muscular dystrophies

72%
Klimczak A., Kozlowska U., Kurpisz M.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 5
15

Adventage of mesenchymal stem cells [MSC] expansion directly from purified bone marrow CD105plus and CD271plus cells

72%
Jarocha D., Lukasiewicz E., Majka M.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 3
307-314
16

alpha2beta1 integrin-mediated mechanical signals during osteodifferentiation of stem cells from the Wharton’s jelly of the umbilical cord

72%
Witkowska-Zimny M., Wrobel E., Mrowka P.
Folia Histochemica et Cytobiologica
|
2014
|
tom 52
|
nr 4
17

Stem cell-based approaches to improve nerve regeneration: potential implications for reconstructive transplantation?

72%
Khalifian S., Sarhane K. A., Tammia M., Ibrahim Z., Mao H.-Q., Cooney D. S., Shores J. T., Lee W. P. A., Brandacher G.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
|
tom 63
|
nr 1
18
Content available remote

Immunomodulatory and potential therapeutic role of mesenchymal stem cells in periodontitis

72%
Racz G. Z., Kadar K., Foldes A., Kallo K., Perczel-Kovach K., Keremi B., Nagy A., Varga G.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 3
19

Effects of maternal age on the expression of mesenchymal stem cell markers in the components of human umbilical cord

72%
Alrefaei G. I., Ayuob N. N., Ali S. S., Al-Karim S.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 3
20

Heterogeneous mixture of amniotic cells is likely a better source of stem cells than adipose tissue

72%
Kitala D., Klama-Baryla A., Misiuga M., Labus W., Kraut M., Szapski M., Lesiak M., Krakowian D., Sieron A. L., Los M. J., Kucharzewski M.
Archivum Immunologiae et Therapiae Experimentalis
|
2019
|
tom 67
|
nr 3
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