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  1. 6 Archivum Immunologiae et Therapiae Experimentalis

  2. 6 Folia Histochemica et Cytobiologica

  3. 5 Acta Biochimica Polonica

  4. 2 Biotechnologia

  5. 2 Cellular and Molecular Biology Letters

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  1. 5 Szala S.

  2. 3 Cichorek M.

  3. 2 Cichon T.

  4. 2 Korohoda W.

  5. 2 Kozlowska K.

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  1. 1 2022

  2. 1 2020

  3. 1 2018

  4. 1 2016

  5. 1 2014

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1

Synergistic antiproliferative activity of tumor necrosis factor alpha [TNF-alpha] and lovastatin

100%
Sora M. K., Kruszewski A. A., Stoklosa T., Czyzyk J., Lasek W., Malejczyk J., Jakobisiak M.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
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tom 42
|
nr 4
2

CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase-5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter

100%
Dabrowska A., Szary J., Kowalczuk M., Szala S., Ugorski M.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 3
Recent studies have suggested that carcinoembryonic antigen (CEA)-promoter se­quences are active only in CEA-positive cells, filing in the criteria for tumor specific targeting of suicide genes. However, the present study on gene therapy of colon can­cer and cell-specificity of CEA promoter, provide evidence that CEA-positive and CEA-negative cells transfected with E. coli cytosine deaminase (CD) gene under the control of CEA promotor sequence are sensitive to enzyme/pro-drug therapy with 5-fluorocytosine (5-FC). Individual clones derived from the CEA-negative cell lines: melanoma Hs294T and glioblastoma T98G after transfection with CD differed pro­foundly in their sensitivity to 5-FC. The IC50 values for several clones of the CEA-neg- ative cells were almost the same as for CEA-positive colon cancer cells. Such 5-FC-sensitive clones derived from the population of CEA-negative cells, present even in small number, because of the very effective bystender effect of this en­zyme/pro-drug system can cause severe problems during therapy by efficiently kill­ing surrounding normal cells. Safety is the major issue in gene therapy. Our data sug­gest that the safety of gene-directed enzyme pro-drug therapy (GDEPT) with CEA promoter driven expression of therapeutic genes is not so obvious as it has originally been claimed.
3

Addition of iron and zinc complexes to Eagle's minimal essential medium is sufficient to induce and support the proliferation of B16 melanoma cells

100%
Korohoda W., Michalik M., Pietrzkowski Z., Zaporowska-Siwiak E.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 1
4

Reversible inhibition of growth of B16 melanoma cells by decreased amino acid nutrition

100%
Korohoda W., Michalik M., Zaporowska-Siwiak E.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 2
5

ZNF750 inhibits the proliferation and invasion of melanoma cells through modulating the Wnt/beta-catenin signaling pathway

84%
Du Y., LV G., Jing C., Liu J., Liu J.
Folia Histochemica et Cytobiologica
|
2020
|
tom 58
|
nr 4
6

Melanization of Bomirski hamster amelanotic melanoma cells (Ab line) depends on the type of culture medium

84%
Skoniecka A., Zauszkiewicz-Pawlak A., Tyminska A., Cichorek M.
Folia Histochemica et Cytobiologica
|
2018
|
tom 56
|
nr 4
7
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Effect of juglone on C-32 and COLO 829 melanoma cells in in vitro cultures

84%
Zielinska A., Plonka-Czerw J., Kusmierz D.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2022
|
tom 103
|
nr 1
8

Tumoricidal effect of macrophages on transplantable melanoma cells with regard to their sensitivity to exogenous cytokines

84%
Cichorek M., Zarzeczna M., Kozlowska K.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
9

Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas

84%
Urbanska K., Romanowska-Dixon B., Matuszak Z., Oszajca J., Nowak-Sliwinska P., Stochel G.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 2
Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
10

Tumorigenicity and metastatic ability of MmB16 mouse melanoma cell line and its two Aleuria aurantia agglutinin resistant variants

84%
Dus D., Matuszyk J., Kusnierczyk H., Strzadala L., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1992
|
tom 40
|
nr 5-6
11

Expression of CD44 on two lines of transplantable melanoma cells - relationship with cytokine secretion and tumor progression

84%
Kozlowska K., Cichorek M., Zarzeczna M., Wojcik S.
Folia Histochemica et Cytobiologica
|
2004
|
tom 42
|
nr 1
12

Inhibition of tumor growth by interleukin 10 gene transfer in B16[F10] melanoma cells

84%
Walos S., Szary J., Szala S.
Acta Biochimica Polonica
|
1999
|
tom 46
|
nr 4
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
13

The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results

84%
Szenajch J., Kozak A., Kruszewski A. A., Babiej E., Chomicka M., Struzyna J., Wiktor-Jedrzejczak W.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 1
Reverse transcription and polymerase chain reaction (RT/PCR) with primers specific for tyrosinase allow for a new method of early detection of individual melanoma cells in peripheral blood. Using this test the effect of chemo- and chemoimmunotherapy on the spread of early micrometastatic cancer cells has been evaluated. No significant correlations have been found between RT/PCR results on the one hand and stage of disease, a kind of the therapy protocol used and usage of the therapy as an adjuvant or palliative on the other hand. Thus, although the RT/PCR test for detection of circulating individual melanoma cells might help in identification of minimal residual disease in some patients, it has no application for routine staging of more advanced disease and in monitoring the response to therapy.
14

In vivo analysis of metastatic process and suppression of metastasis

84%
Oku N.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 2
15

Immune response against genetically modified tumour cells

84%
Nowak J., Januszkiewicz D., Kowalczyk D., Mazurek J., Laciak M., Malicki J., Murawa P., Wiznerowicz M., Heinrich P. C., Rose-John S., Mackiewicz A.
Biotechnologia
|
1996
|
nr 4
16

Effect of structural modification at the 4,3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells

84%
Gruber B. M., Anuszewska E. L., Bubko I., Gozdzik A., Fokt I., Priebe W.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 3
17

D-K6L9 peptide combination with IL-12 inhibits the recurrence of tumors in mice

67%
Cichon T., Smolarczyk R., Matuszczak S., Barczyk M., Jarosz M., Szala S.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
|
tom 62
|
nr 4
18

Properties of B16-F10 murine melanoma cells subjected to metabolic stress conditions

67%
Mitrus I., Bryndza E., Kazura M., Smagur A., Sochanik A., Cichon T., Szala S.
Acta Biochimica Polonica
|
2012
|
tom 59
|
nr 3
Neoplastic cells which co-form tumors are usually subjected to various stress factors, mainly hypoxia and shortage of nutrient factors. Such cells employ different strategies that permit their survival under such conditions. Experiments in vitro are usually carried out in the presence of 21% oxygen and medium supplemented with 10% FBS. Altering these parameters can approximate the in vivo conditions found within tumor mass. The present paper reports certain properties (especially ability to metastasize) of B16-F10 cells able to grow upon exposure to altered growth conditions (medium supplemented with 0.06% FBS or presence of 1% oxygen for 24 or 72 hours). These properties were compared with those of control cells cultured in the presence of 21% oxygen and in medium supplemented with 10% FBS. Some properties of the cells exposed to medium supplemented with 0.06% FBS differ from those of cells cultured under low oxygenation conditions (ability to form metastases, to migrate, or to express various proteins). Only the partial deprivation of oxygen did increase both the number of migrating cells and the number of metastases formed. Serum deficiency enhanced only the cell ability to metastasize, but not to migrate. It appears that cultured B16-F10 cells employ different adaptation strategies under conditions of oxygen shortage and those of serum deficiency. Under oxygen deprivation, such cells most likely undergo an epithelial-mesenchymal transition, whereas serum deficiency ("starvation"), while increasing the tumorigenicity of B16-F10 cells, does not induce the epithelial-mesenchymal transition.
19

Expression of caveolin-1 in human cutaneous and uveal melanoma cells

67%
Belkot K., Bubka M., Litynska A.
Folia Biologica
|
2016
|
tom 64
|
nr 3
20

Evaluation of melanogenesis in A-375 melanoma cells treated with 5,7-dimethoxycoumarin and valproic acid

67%
Chodurek E., Orchel A., Orchel J., Kurkiewicz S., Gawlik N., Dzierzewicz Z., Stepien K.
Cellular and Molecular Biology Letters
|
2012
|
tom 17
|
nr 4
Malignant melanoma (melanoma malignum) is one of the most dangerous types of tumor. It is very difficult to cure. In recent years, a lot of attention has been given to chemoprevention. This method uses natural and synthetic compounds to interfere with and inhibit the process of carcinogenesis. In this study, a new treatment strategy was proposed consisting of a combination of 5,7-dimethoxycoumarin (DMC), an activator of melanogenesis, and valproic acid (VPA), a well-known drug that is one of the histone deacetylase inhibitors (HDACis). In conjunction with 1 mM VPA, all of the tested concentrations of DMC (10–150 μM) significantly decreased the proliferation of A-375 cells. VPA and DMC also induced the synthesis of melanin and the formation of dendrite and star-shaped cells. Tyrosinase gene expression and tyrosinase activity significantly increased in response to VPA treatment. Pyrolysis with gas chromatography and mass spectrometry (Py-GC/MS) was used to investigate the structure of the isolated melanin. This showed that the quantitative and qualitative components of melanin degradation products are dependent on the type of applied melanogenesis inductor. Products derived from eumelanin were detected in the pyrolytic profile of melanin isolated from A-375 cells stimulated with DMC. Thermal degradation of melanin isolated from melanoma cells after exposure to VPA or a mixture of VPA and DMC revealed the additional presence of products derived from pheomelanin.
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