Wyniki wyszukiwania - AGRO

1

Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1

100%

Markuszewska-Kuczynska A., Klimkowska M., Regenthal S., Bulanda A., Bjorkvall C. K., Machaczka M.

Folia Histochemica et Cytobiologica

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2015

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tom 53

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nr 1

2

Semi-stable production of bovine IL-4 and GM-CSF in the mammalian episomal expression system

100%

Blanco F. C., Vazquez C. L., Garcia J. S., Rocha R. V., Gravisaco M. J., Forrellad M. A., Magistrelli G., Bigi F.

Journal of Veterinary Research

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2021

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tom 65

|

nr 3

3

Thymocyte-macrophage interactions. Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages

100%

Zimecki M., Wieczorek Z., Kapp J. A.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 3

4

Phagocytic and bactericidal properties of macrophages of mice immunized with outer membrane proteins (OMP) of Shigella

86%

Czarny A., Witkowska D., Mulczyk M.

Archivum Immunologiae et Therapiae Experimentalis

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1988

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tom 36

|

nr 6

5

Carvedilol and adrenergic agonists suppress the lipopolysaccharide-induced NO production in RAW 264.7 macrophages via the adrenergic receptors

86%

Pekarova M., Kralova J., Kubala L., Ciz M., Papezikova I., Macickova T., Pecivova J., Nosal R., Lojek A.

Journal of Physiology and Pharmacology

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2009

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tom 60

|

nr 1

143-150

The interaction of adrenergic agonists and/or antagonists with the adrenergic receptors expressed on immunologically active cells including macrophages plays an important role in regulation of inflammatory responses. Our study investigated the effects of carvedilol, a unique vasodilating b-adrenergic antagonist, and endogenous adrenergic agonists (adrenalin, noradrenalin, and dopamine) and/or antagonists (prazosin, atenolol) on lipopolysaccharide-stimulated nitric oxide (NO) production from murine macrophage cell line RAW 264.7. The production of NO was determined as the concentration of nitrites in cell supernatants (Griess reaction) and inducible nitric oxide synthase (iNOS) protein expression (Western blot analysis). Scavenging properties against NO were measured electrochemically. Carvedilol in a concentration range of 1, 5, 10 and 25 µM inhibited iNOS protein expression and decreased the nitrite concentration in cell supernatants. Adrenalin, noradrenalin or dopamine also inhibited the iNOS protein expression and the nitrite accumulation. Prazosine and atenolol prevented the effect of both carvedilol and adrenergic agonists on nitrite accumulation and iNOS expression in lipopolysaccharide-stimulated cells. These results, together with the absence of scavenging properties of carvedilol against NO, imply that both carvedilol and adrenergic agonists suppress the lipopolysaccharide-evoked NO production by macrophages through the activation and modulation of signaling pathways connected with adrenergic receptors.

6

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Survival of Corynebacterium pseudotuberculosis within macrophages and induction of phagocytes death

86%

Stefanska I., Gierynska M., Rzewuska M., Binek M.

Polish Journal of Veterinary Sciences

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2010

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tom 13

|

nr 1

143-149

Since C. pseudotuberculosis is a facultative intracellular pathogen the aim of this study was focused on evaluating mechanisms that allowed these bacteria to survive in macrophages and determining their influence on induction of cell death. The influence of Corynebacteria on the programmed cell death of macrophages was determined on the basis of induction the autophagy and apoptosis in the cultures of murine macrophage cell lines J774 infected with bacteria. Corynebacterium pseudotuberculosis strains could survive within macrophages more than 48 hours. During that time bacteria were released as a result of the process that lead to death of phagocytes. This property varied among studied strains. There was no increase of micro- tubule-associated protein I light chain 3 (MAP I LC3) activity in macrophages infected with examined strains comparing with uninfected cultures and cultures treated with autophagy inducer (rapamycin) that served as negative and positive controls, respectively. The study with confocal microscopy did not show the increasing of caspase-3 activity in the infected macrophages and their nucleus did not reveal the fragmentation.

7

Electron microscope picture of the epithelium and epithelial-connective borderline in leukoplakia of the buccal mucous membrane

86%

Knychalska-Karwan Z., Pawlicki R.

Folia Histochemica et Cytobiologica

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1985

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tom 23

|

nr 3

8

Modulation of murine macrophages and T lymphocytes by lysozyme dimer

86%

Obminska-Mrukowicz B., Szczypka M., Gaweda B.

Polish Journal of Veterinary Sciences

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2002

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tom 05

|

nr 4

The effects of lysozyme dimer (2 and 20 μg/kg) administered i.p. once and four times to mice on the phagocytic and killing ability of peritoneal macrophages, interleukin-1 (IL-1) production by murine macrophages stimulated in vitro with lipopolisaccharide of E. coli and expression of thymocyte, splenocyte and mesenteric lymphonode cell CD3+, CD4+ and CD8+ markers were studied. It was found that lysozyme dimer administered once or four times at doses of 2 (μg/kg and 20 μg/kg augments the phagocytic and killing activity of peritoneal macrophages. The strongest stimulating effect was noted after four injections of lysozyme dimer at a dose of 20 μg/kg. Moreover, lysozyme dimer is able to modulate the production of IL-1 by murine macrophages stimulated in vitro with LPS. Exposure to four doses of lysozyme dimer (20 μg/kg) enhances the synthesis and release of IL-1, but this drug administered once (2 μg/kg and 20 μg/kg) or four times (2 μg/kg) decreases IL-1 production by peritoneal macrophages. It was also found that administration of lysozyme dimer at a dose of 20 μg/kg, irrespective of the number of doses applied, increases the percentage of CD4+ thymocytes and splenocytes. Moreover, exposure to four doses of lysozyme dimer (2 and 20 μg/kg) increases the percentage of CD4+ and CD8+ mesenteric lymphonode cells.

9

TCRalphabeta plus CD8plus and TCRgammadeltaplus lymphocytes inhibit the capability of peritoneal macrophages to induce contact hypersensitivity

86%

Majewska M., Zajac K., Zemelka M., Sura P., Gryglewski A., Szczepanik M.

Folia Biologica

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2009

|

tom 57

|

nr 1-2

23-27

10

Macrophage profile in primary versus secondary liver tumors

86%

Avadanei E.-R., Wierzbicki P. M., Giusca S.-E., Grigoras A., Amalinei C., Caruntu I.-D.

Folia Histochemica et Cytobiologica

|

2014

|

tom 52

|

nr 2

11

Role of bronchoalveolar lavage in the initial diagnosis of smoking-related interstitial lung diseases

86%

Domagala-Kulawik J., Maskey-Warzechowska M., Krenke R., Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

|

nr 6

243-251

12

Cellular elements of the immune system in the larynx cancer, SEM study

86%

Kus J., Miodonski A. J., Olszewski E., Sekula J.

Folia Histochemica et Cytobiologica

|

1985

|

tom 23

|

nr 3

13

Encephalitozoon intestinalis infection impacts the expression of apoptosis-related genes in U937 macrophage cells

86%

Cetinkaya U., Caner A., Charyyeva A., Senturk M., Eren M.

Acta Parasitologica

|

2021

|

tom 66

|

nr 2

14

Glial scar instability after brain injury

86%

Frontczak-Baniewicz M., Walski M.

Journal of Physiology and Pharmacology. Supplement

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2006

|

tom 57

|

nr 4

97-102

Glial scar is formed following surgical damage to the cerebral cortex. In the present study we examined the ultrastructural status of the cerebral cortex 14 to 180 days following surgical damage to cerebral parenchyma. The results showed a contribution of astrocytes, but also mesodermal cells, to the process of scar formation. Furthermore, our study showed that the process initiated by trauma did not terminate with the formation of a glial scar. Late phases of repair following tissue damage were associated with lytic processes and a disassembly of the cerebral parenchyma. These findings indicate a changing and unstable nature of the glial scar and its components.

15

The influence of recombinant human tumor necrosis factor [rh-TNFalpha] on granulocyte-macrophage progenitor cells [CFU-GM] and clonogenic leukaemic blasts [CFU-L] in cultures in vitro

86%

Robak T., Korycka A., Gora-Tybor J., Piotrowska-Wrzesien A., Krykowski E.

Archivum Immunologiae et Therapiae Experimentalis

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1992

|

tom 40

|

nr 5-6

16

Interleukin 3-dependent, asialo-GM1-positive cell line with natural cytotoxic but without natural killer cytotoxic activity

86%

Strzadala L., Ziolo E., Matuszyk J.

Archivum Immunologiae et Therapiae Experimentalis

|

1994

|

tom 42

|

nr 3

17

The effects of taxol [paclitaxel] on chemiluminescence of neutrophils, macrophages and J.774.2 cell line

86%

Czuba Z. P., Krol W., Hasinski P., Nowowiejska A.

Acta Biochimica Polonica

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1998

|

tom 45

|

nr 1

Taxol (paclitaxel) is a chemotherapeutic diterpene with promising anticancer activity that blocks cell division by preventing microtubule depolymerization. Furthermore, recent studies have shown that taxol has other intracellular effects that may contribute to its effect, particularly in macrophages. The signal transduction mechanisms by which taxol stimulates macrophages to anticancer activity are not clear. The purpose of this study was to determine the effect of taxol on chemiluminescence (an indicator of the production of free radicals) of neutrophils, macrophages and murine macrophage J.774.2 cells. The chemiluminescence was measured in the presence of taxol andór phorbol myristate acetate (PMA) as a stimulant. Taxol stimulated chemiluminescence (without PMA) of neutrophils and macrophages but not of J.774.2 cells, and modulated chemiluminescence of the cells stimulated with PMA.

18

Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease

86%

Liberski P. P., Sikorska B., Bratosiewicz-Wasik J., Walis A., Brown P., Brown D.

Acta Neurobiologiae Experimentalis

|

2003

|

tom 63

|

nr 4

19

The effect of danazol on the activity of peritoneal macrophages

86%

Kurzawa R., Barcew-Wiszniewska B., Skowron J.

Folia Histochemica et Cytobiologica

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1997

|

tom 35

|

nr 2

20

Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages

86%

Jozkowicz A., Dulak J.

Acta Biochimica Polonica

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2003

|

tom 50

|

nr 1

Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis. Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1. We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability. All experiments were performed on rat vascular smooth muscle cells and murine RAW264.7 macrophages treated with 3-10 ,uM protoporphyrins. Some cells were additionally stimulated with IL-1β or with lipopolysaccharide. After a 24 h incubation period SnPPIX and ZnPPIX significantly reduced the generation of VEGF in vascular smooth muscle cells and RAW264.7, both in resting and stimulated cells. The inhibitory potentials of both protoporphyrins on VEGF synthesis were very similar. In contrast, analysis of iNOS activity revealed that results obtained with different HO-1 inhibitors are discrepant.

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