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Lead-induced oxidative stress, antioxidant defence system and their response to administration of L-arginine in rats with different resistance to hypoxia

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Tkachenko H., Kurhalyuk N.

Bulletin of the Veterinary Institute in Puławy

2011

tom 55

nr 3

The influence of L-arginine and Nω-nitro-L-arginine (L-NNA) on lead-induced oxidative stress in kidneys of rats with different resistance to hypoxia was studied. The animals were exposed to lead nitrate (3.6 mg/kg, daily) for 30 d and treated with L- arginine (600 mg/kg) or L-NNA (35 mg/kg) 30 min before each injection of lead nitrate. Lead exposure led to a significant increase in the level of thiobarbituric acid reactive substances (TBARS) in rats with high resistance to hypoxia indicating that lead induced renal oxidative stress. Treatment with L-arginine was effective in decreasing TBARS level for this group of animals. L-arginine was ineffective against lead-induced oxidative stress when given to rats with low resistance to hypoxia. In contrast, administration of L- NNA provided significant prooxidative effect on renal lead-induced oxidative stress in rats with low and high resistance to hypoxia. Renal antioxidant defence system remained sensitive to lead-induced oxidative stress and any of the treatments bv L-arginine and L- NNA.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Kurhalyuk N.

1 Tkachenko H.

1 2011

Wyniki wyszukiwania

Lead-induced oxidative stress, antioxidant defence system and their response to administration of L-arginine in rats with different resistance to hypoxia