Wyniki wyszukiwania

1

The response of plant NAD kinase to abiotic stresses

100%

Slaski J. J., Zagdanska B., Maciejewska U.

Acta Biochimica Polonica

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1993

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tom 40

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nr 2

2

Orally-active pyridopyrimidine inhibitors of transforming growth factor beta RI [ALK5] kinase. Structure and activity, in-vitro and in-vivo characterization

88%

Chakravarty S., Dugar S.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

3

Peptide micro-arrays for kinase profiling

88%

Schutkowski M., Reimer U., Panse S., Dong L., Schneider-Mergener J.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

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nr 2A

4

Structural studies on CDK2-inhibitor complexes

88%

Endicott J.

Cellular and Molecular Biology Letters

|

1998

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tom 03

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nr 3

5

Structural basis of oncogenesis caused by point mutations in the kinase domain of the MET proto-oncogene

75%

Miller M., Zbar B., Ginalski K., Lesyng B.

Cellular and Molecular Biology Letters

|

1998

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tom 03

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nr 3

6

Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets

75%

Mendoza F. J., Espino P. S., Cann K. L., Bristow N., McCrea K., Los M.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

|

nr 1

7

Physiology of cGMP kinases

75%

Ruth P., Pfeifer A., Hofmann F.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 3

8

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Influence of Epilobium angustifolium extract on 5alpha-reductase type 2 and MAPK3 kinase gene expression in rats prostates

63%

Kujawski R., Bartkowiak-Wieczorek J., Karasiewicz M., Bogacz A., Mikolajczak P. L., Czerny B., Mrozikiewicz P. M.

Herba Polonica

|

2013

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tom 59

|

nr 4

The aim of this study was to investigate the influence of standardized Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of 5α-reductase type 2 (Srd5ar2) mRNA and Mapk3 mRNA a representative of non-genomic xenobiotics signaling pathway. It was shown that plant extract from the E. angustifolium showed a slight tendency to reduce prostate weight in hormonally induced animals (p>0.05) and in testosterone induced animals receiving both, extract and finasteride (p<0.05). Finasteride in rats induced by testosterone caused a smaller decrease in the level of mRNA 5α-steroid reductase 2 (SRd5ar2), than in rats treated with the hormone and studied plant extracts. In general, an increase in the amount of MAPK3 mRNAs in testosterone-induced groups of rats receiving tested plant extract with or without finasteride was observed, while the expression of type 2 5α-steroid reductase decreased (p<0.05). Further experimental studies should be performed in order to understand the molecular basis of interactions, the efficacy and safety of tested plant extracts.

9

Quantum and quantum-classical studies of phosphoryl-transfer mechanisms in model systems

63%

Grochowski P.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

10

Designing specific inhibitors of the bacterial HPr kinase-phosphorylase

63%

Nessler S.

Cellular and Molecular Biology Letters

|

2005

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tom 10

|

nr Suppl.2

11

Chromosomes and microtubules are not necessary for inactivation and reactivation of cdc2-cyclin B kinase during transition between M I and M II in mouse oocytes

63%

Polanski Z., Brunet S., Kubiak J.

Acta Biologica Cracoviensia. Series Botanica et Zoologia. Supplement

|

1997

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tom 39

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nr 1

12

Regulatory functions of seryl-phosphorylated HPr in pathogenic bacteria

63%

Deutscher J., Herro R., Poncet S.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

13

Mammalian histidine kinases

63%

Attwood P. V., Besant P. G.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

14

A comparative study of the primary structures of protein and sugar kinases

63%

Leluk J., Lesyng B.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

15

Purification and characterization of the protein kinase eEF-2 isolated from rat liver cells

63%

Gajko A., Galasinski W., Gindzienski A.

Acta Biochimica Polonica

|

1994

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tom 41

|

nr 4

The elongation factor 2 (eEF-2) protein kinase was isolated from rat liver cells, purified and partly characterized. It was found that the enzyme exists in an inactive form in the homogenate of rat liver. The active fraction of kinase eEF-2 was obtained after removal of the inhibitory substance by hydroxyapatite column chromatography. The purified enzyme is an electTophoretically homogeneous protein with relative molecular mass of approximately 90000 and isoelectric point, pi = 5.9. The enzyme specifically phosphorylates the elongation factor eEF-2 in the presence of calmodulin and Ca2+.

16

Influence of redox agents on activity of protein tyrosine phosphatases and kinases in human aortic endothelial cells

63%

Zielinski B., Seweryn E., Banas T.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 2

17

mTOR and p70 S6K phosphorylation by insulin plus rapamycin in HepG2 cells with and without overexpression of constitutively active Akt-PKB

63%

Varma S., Gupta D., Khandelwal R. L.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

18

Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels

51%

Weier H.-U. G., Kwan J., Lu C.-M., Ito Y., Wang M., Baumgartner A., Hayward S. W., Weier J. F., Zitzelsberger H. F.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 4

19

Molecules released by helminth parasites involved in host colonization

51%

Dzik J. M.

Acta Biochimica Polonica

|

2006

|

tom 53

|

nr 1

Parasites are designed by evolution to invade the host and survive in its organism until they are ready to reproduce. Parasites release a variety of molecules that help them to penetrate the defensive barriers and avoid the immune attack of the host. In this respect, particularly interesting are enzymes and their inhibitors secreted by the parasites. Serine-, aspartic-, cysteine-, and metalloproteinases are involved in tissue invasion and extracellular protein digestion. Helminths secrete inhibitors of these enzymes (serpins, aspins, and cystatins) to inhibit proteinases, both of the host and their own. Proteinases and their inhibitors, as well as helminth homologues of cytokines and molecules containing phosphorylcholine, influence the immune response of the host biasing it towards the anti-inflammatory Th2 type. Nucleotide-metabolizing enzymes and cholinesterase are secreted by worms to reduce inflammation and expel the parasites from the gastrointestinal tract. An intracellular metazoan parasite, Trichinella spiralis, secretes, among others, protein kinases and phosphatases, endonucleases, and DNA-binding proteins, which are all thought to interfere with the host cellular signals for muscle cell differentiation. Secretion of antioxidant enzymes is believed to protect the parasite from reactive oxygen species which arise from the infection-stimulated host phagocytes. Aside from superoxide dismutase, catalase (rarely found in helminths), and glutathione peroxidase (selenium-independent, thus having a poor activity with H2O2), peroxiredoxins are probably the major H2O2-detoxifying enzymes in helminths. Secretion of antioxidant enzymes is stage-specific and there are examples of regulation of their expression by the concentration of reactive oxygen species surrounding the parasite. The majority of parasite-secreted molecules are commonly found in free-living organisms, thus parasites have only adapted them to use in their way of life.

20

Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells

45%

Ligeza J., Ligeza J., Klein A.

Acta Biochimica Polonica

|

2011

|

tom 58

|

nr 3

Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase inhibitors (tyrphostins). Selected growth factor/growth factor receptor loops (mainly TGFα/EGFR and IGFs/IGFIR) have been proposed as regulators of prostate cancer cell growth. We have previously determined that blockade of IGFIR or VEGF2R signaling pathways by tyrphostin AG1024 and SU1498 inhibits autocrine growth and viability of DU145 cells in vitro. Recently, we compared the activity of AG1024 and SU1498 with the inhibiting effect of tyrphostin A23 (a selective inhibitor of EGFR). The results described in this paper confirm that DU145 cells do not produce IGFI or EGF. In contrast, DU145 cells produce a great amount of VEGF, much more than TGFα (about 60-fold), and VEGF may be the real autocrine growth factor of the investigated cells. The results indicate that the growth of DU145 may be regulated by at least three autocrine loops: TGFα/EGFR, IGFII/IGFIR and VEGF/VEGFR2. Neither AG1024 nor SU1498 affected the production of TGFα substantially, which excludes the possibility that IGFRs or VEGFR2 inhibitors arrest the growth of these cells by inhibition of synthesis and/or secretion of TGFα. The obtained data indicate that all tree investigated tyrphostins (AG1024, SU1498 and A23) inhibit signal transmission by Akt (PKB), ERK(1/2), Src and STAT in a similar manner. A comparison of the effects of the investigated tyrphostins indicates that TGFα, IGFII and VEGF stimulate cell growth by affecting the same signaling pathway. The hypothesis was confirmed by the effect of the investigated tyrphostins on activation of EGFR. All these inhibitors decreased phosphorylation of EGFR to the same extent, and after the same time of incubation with cell culture. These results strongly suggest that stimulation of EGFR kinase is the main step in the initiation of mitogen signaling in DU145 cells, regardless of the type of ligand (TGFα, IGFs or VEGF) and their specific receptors.

Ograniczanie wyników

The response of plant NAD kinase to abiotic stresses

Orally-active pyridopyrimidine inhibitors of transforming growth factor beta RI [ALK5] kinase. Structure and activity, in-vitro and in-vivo characterization

Peptide micro-arrays for kinase profiling

Structural studies on CDK2-inhibitor complexes

Structural basis of oncogenesis caused by point mutations in the kinase domain of the MET proto-oncogene

Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets

Physiology of cGMP kinases

Influence of Epilobium angustifolium extract on 5alpha-reductase type 2 and MAPK3 kinase gene expression in rats prostates

Quantum and quantum-classical studies of phosphoryl-transfer mechanisms in model systems

Designing specific inhibitors of the bacterial HPr kinase-phosphorylase

Chromosomes and microtubules are not necessary for inactivation and reactivation of cdc2-cyclin B kinase during transition between M I and M II in mouse oocytes

Regulatory functions of seryl-phosphorylated HPr in pathogenic bacteria

Mammalian histidine kinases

A comparative study of the primary structures of protein and sugar kinases

Purification and characterization of the protein kinase eEF-2 isolated from rat liver cells

Influence of redox agents on activity of protein tyrosine phosphatases and kinases in human aortic endothelial cells

mTOR and p70 S6K phosphorylation by insulin plus rapamycin in HepG2 cells with and without overexpression of constitutively active Akt-PKB

Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels

Molecules released by helminth parasites involved in host colonization

Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells