Wyniki wyszukiwania

1

Molecular biomedicine and the unraveling of complex phenotypes

100%

Pignatti P. F.

Journal of Applied Genetics

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2004

|

tom 45

|

nr 4

2

The function of interleukin 17 in the pathogenesis of rheumatoid arthritis

100%

Paradowska A., Maslinski W., Grzybowska-Kowalczyk A., Lacki J.

Archivum Immunologiae et Therapiae Experimentalis

|

2007

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tom 55

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nr 5

3

Combining medicinal chemistry with chemogenomic and computer-aided structure-based design in development of novel kinase inhibitors

86%

Vieth M., Brooks H. B., Hamdouchi C., McMillen W., Sawyer J. S., Yingling J. M., Zhang F.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

A stable density approach to probe selection for a custom aCGH design

72%

Gambin T., Stankiewicz P., Gambin A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2011

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tom 92

|

nr 3

5

Application of non-radioactive methods of DNA detection in analysis of human genetic disorders

72%

Slomski R., Reiss J., Jungerman M.

Acta Biochimica Polonica

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1989

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tom 36

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nr 3-4

6

Loss of heterozygosity [LOH] - implications for human genetic identification

72%

Pepinski W., Soltyszewski I., Skawronska M., Rogowski M., Zalewska R., Kozlowski L., Filipowski T., Janica J.

Folia Histochemica et Cytobiologica

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2009

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tom 47

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nr 1

105-110

7

The human genome structure and organization

72%

Makalowski W.

Acta Biochimica Polonica

|

2001

|

tom 48

|

nr 3

Genetic information of human is encoded in two genomes: nuclear and mitochondrial. Both of them reflect molecular evolution of human starting from the beginning of life (about 4.5 billion years ago) until the origin of Homo sapiens species about 100000 years ago. From this reason human genome contains some features that are common for different groups of organisms and some features that are unique for Homo sapiens. 3.2 X 10 base pairs of human nuclear genome are packed into 23 chromosomes of different size. The smallest chromosome - 21st contains 5 X 10 7 base pairs while the biggest one -1st contains 2.63 X 10 8 base pairs. Despite the fact that the nucleotide sequence of all chromosomes is established, the organisation of nuclear genome put still questions: for example: the exact number of genes encoded by the human genome is still unknown giving estimations from 30 to 150 thousand genes. Coding sequences represent a few percent of human nuclear genome. The majority of the genome is represented by repetitive sequences (about 50%) and noncoding unique sequences. This part of the genome is frequently wrongly called "junk DNA". The distribution of genes on chromosomes is irregular, DNA fragments containing low percentage of GC pairs code lower number of genes than the fragments of high percentage of GC pairs.

8

The RIO kinases: structural studies of a family of atypical protein kinases required for ribosome biogenesis and cell cycle progression

72%

LaRonde-LeBlanc N., Wlodawer A.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

9

High throughput protein production

58%

Tworak A., Podkowinski J., Figlerowicz M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2011

|

tom 92

|

nr 2

10

Sp100 interacts with phage ΦC31 integrase to inhibit its recombination activity

58%

Lin Y., Li Z., Wang J., Xu G., Shen Q., Tian L., Xue J., Chen J.

Acta Biochimica Polonica

|

2011

|

tom 58

|

nr 1

Phage ΦC31 integrase is a potential vector for the insertion of therapeutic genes into specific sites in the human genome. To understand the mechanism involved in ΦC31 integrase-mediated recombination, it is important to understand the interaction between the integrase and cellular proteins. Using a yeast two-hybrid system with pLexA-ΦC31 integrase as bait, we screened a pB42AD human fetal brain cDNA library for potential interacting cellular proteins. From the 106 independent clones that were screened, 11 potential interacting clones were isolated, of which one encoded C-terminal fragment of Sp100. The interaction between Sp100 and ΦC31 integrase was further confirmed by yeast mating and co-immunoprecipitation assays. The hybridization between a ΦC31 integrase peptide array and an HEK293 cell extract revealed that residues 81RILN84 in the N-terminus of ΦC31 integrase are responsible for the interaction with Sp100. Knocking down endogenous Sp100 with Sp100-specific siRNA increased ΦC31 integrase-mediated recombination but did not impact reporter gene expression. Therefore, endogenous Sp100 may interact with ΦC31 integrase and inhibit the efficiency of ΦC31 integrase-mediated recombination.

11

Human genome sequenced: achievements and shortcomings in big science

58%

Blin N.

Journal of Applied Genetics

|

2001

|

tom 42

|

nr 4

12

Noncoding RNA transcripts

58%

Szymanski M., Barciszewska M. Z., Zywicki M., Barciszewski J.

Journal of Applied Genetics

|

2003

|

tom 44

|

nr 1

Ograniczanie wyników

Molecular biomedicine and the unraveling of complex phenotypes

The function of interleukin 17 in the pathogenesis of rheumatoid arthritis

Combining medicinal chemistry with chemogenomic and computer-aided structure-based design in development of novel kinase inhibitors

A stable density approach to probe selection for a custom aCGH design

Application of non-radioactive methods of DNA detection in analysis of human genetic disorders

Loss of heterozygosity [LOH] - implications for human genetic identification

The human genome structure and organization

The RIO kinases: structural studies of a family of atypical protein kinases required for ribosome biogenesis and cell cycle progression

High throughput protein production

Sp100 interacts with phage ΦC31 integrase to inhibit its recombination activity

Human genome sequenced: achievements and shortcomings in big science

Noncoding RNA transcripts