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Hepatoprotective and antioxidant activity of Lannea coromandelica Linn. on thioacetamide induced hepatotoxicity in rats

100%

Srinivasa Rao V., Wilkin Einstein J., Das K.

International Letters of Natural Sciences

2014

tom 03

Hepatoprotective and antioxidant activity of Lannea coromandelica bark extract (LCBE) was investigated on thioacetamide induced hepatotoxicity in rats. Hepatotoxicity was induced by thioacetamide (TAA) administration (100 mg/kg. s.c). LCBE at different doses (400 and 200 mg/kg) were administered orally to male wistar rats. Thioacetamide caused elevation of serum concentration of AST, ALT, ALP, serum bilirubin and also reduced serum concentration of total protein, albumin, sodium, potassium in animals as compared to control (p < 0.05) but LCBE treated rats showed maximum reduction of AST [(138±5.1) IU/L], ALT [(71 ±2.7) IU/L], ALP [(140 ±1.9) IU/L] with the high dose (400 mg/kg bw) of combined aqueous and alcoholic bark extract. Whereas, serum bilurubin, cholesterol, sugar and LDH content were varied with the treatments but showed higher with the only ethanolic extract at dose of 400 mg/kg. The IC50 value was observed as (83.28 ±2.12) μg/mL, for DPPH radical scavenging activity. Result concluded that ethanolic extract and combined aqueous and alcoholic bark extract of L. coromandelica showed a potential hepatoprotective and antioxidant activities might be due to the presence of phenolic groups, terpenoids and alkaloids.

A comprehensive review on bergenin, a potential hepatoprotective and antioxidative phytoconstituent

100%

Rastogi S., Rawat A. K. S.

Herba Polonica

2008

tom 54

nr 2

Bergenin (1) is a C-glucoside of 4-O-methylgallic acid that has been reported to occur naturally in several genera. It exhibits a wide array of biological activities and also in several cases is responsible for the traditional use of its natural sources. It has been shown to exhibit various pharmacological activities, and thus has several possible applications in clinical research. This review presents a comprehensive literature search of different studies carried out on this secondary metabolite, especially its hepatoprotective potential, antioxidative and antiviral effects as well as antiulcerogenic and antiarthritic activities. Bergenin seems to be a potent phytotherapeutic agent as demonstrated by experimental data in animal models. Therefore, further investigations may help in exploiting its properties and developing phyto-pharmaceuticals based on it.

Fibroblast growth factor-21 and omentin-1 hepatic mRNA expression and serum levels in morbidly obese women with non-alcoholic fatty liver disease

67%

Waluga M., Kukla M., Zorniak M., Kajor M., Liszka L., Dyaczynski M., Kowalski G., Zadlo D., Waluga E., Olczyk P., Buldak R. J., Berdowska A., Hartleb M.

Journal of Physiology and Pharmacology

2017

tom 68

nr 3

Ograniczanie wyników

1 Herba Polonica

1 International Letters of Natural Sciences

1 Journal of Physiology and Pharmacology

1 Berdowska A.

1 Buldak R. J.

1 Das K.

1 Dyaczynski M.

1 Hartleb M.

1 Kajor M.

1 Kowalski G.

1 Kukla M.

1 Liszka L.

1 Olczyk P.

1 Rastogi S.

1 Rawat A. K. S.

1 Srinivasa Rao V.

1 Waluga E.

1 Waluga M.

1 Wilkin Einstein J.

1 Zadlo D.

1 Zorniak M.

1 2017

1 2014

1 2008

Wyniki wyszukiwania

Hepatoprotective and antioxidant activity of Lannea coromandelica Linn. on thioacetamide induced hepatotoxicity in rats

A comprehensive review on bergenin, a potential hepatoprotective and antioxidative phytoconstituent

Fibroblast growth factor-21 and omentin-1 hepatic mRNA expression and serum levels in morbidly obese women with non-alcoholic fatty liver disease