Wyniki wyszukiwania

1

Nanoparticles for targeted delivery of anticancer agents

100%

Storm G., Molema G., Woodle M., Metselaar B., Schiffelers R.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.

2

Long-circulating liposomes for I.V. targeted delivery of glucocorticoids in arthritis

88%

Metselaar J. M., Wauben M. H. M., Boerman O. C., Van Lent P. L., Storm G.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr 2

3

The overproduction of nitric oxide associated with neutrophilic predominance is relevant to airway mycotic infections in asthmatics undergoing prolonged glucocorticoid treatment

88%

Cembrzynska-Nowak M., Liebhart J., Bienkowska-Haba M., Liebhart E., Kulczak A., Siemieniec I., Dobek R., Dor A., Barg W., Panaszek B.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr 4

4

Plasma glucocorticoids and ACTH levels during different periods of activity in the European beaver (Castor fiber L.)

75%

Czerwinska J., Chojnowska K., Kaminski T., Bogacka I., Panasiewicz G., Smolinska N., Kaminska B.

Folia Biologica

|

2015

|

tom 63

|

nr 4

5

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Prenatal glucocorticoids can programme postnatal development

75%

Tomaszewska E., Dobrowolski P.

Journal of Pre-Clinical and Clinical Research

|

2011

|

tom 05

|

nr 1

6

Hormonal adaptation and the stress of exercise training: the role of glucocorticoids

75%

Hackney A. C., Walz E. A.

Trends in Sport Sciences

|

2013

|

tom 20

|

nr 4

7

Changes in glucocorticoid-induced apoptosis and in expression of Bcl-2 protein during long-term culture of thymic lymphoma

75%

Kobzdej M., Matuszyk J., Ziolo E., Strzadala L.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

|

tom 48

|

nr 1

8

Suppression of mast cell activation by glucocorticoid

63%

Yoshikawa H., Tasaka K.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

|

tom 48

|

nr 6 Spec.Iss.

487-495

9

The role of interleukin 6 in stress response and anxiety-driven behavior in mice

63%

Aniszewska A., Chlodzinska N., Turlejski K., Djavadian R.

Acta Neurobiologiae Experimentalis

|

2013

|

tom 73

|

nr 1

Interleukin 6 (IL-6) plays an important role in stress response and glucocorticoid action on the brain. It has been also shown that IL-6 plays a significant role in physiological and pathological brain development and is a crucial factor in the effects of prenatal immune challenge on physiological and behavioral abnormalities in adult offspring. We examined involvement of IL-6 in stressinduced changes in behavior and brain mechanisms in the adult mice. The PhenoRack system was used to non-invasively monitor mice home cage activity. Behavior of wild type mice C57BL/6J and IL-6 -/- knockout (IL-6 KO) mice were observed for 3 days using the PhenoRack system, which enables non-invasive monitoring of the mice home-cage activity (distance travelled, speeds and duration of movement, freezing). Mice were also subjected to standard behavioral tests. The open field test was used to establish the balance between exploratory behavior and anxiety evoked by the unknown, potentially dangerous situation. We measured the distance travelled in the open part of the arena, as well as time spent in it. We observed the sex-dependent effect of IL-6 on exploratory behavior. In all tested parameters IL-6 deficient females showed less anxiety than the wild type females. There was no difference in behavior in the open field between wild type and IL-6 deficient males. After finishing behavioral tests, the animals were killed with an overdose of pentobarbital and their brains were perfused transcardially with saline (0.9% NaCl) followed by 4% paraformaldehyde in 0.1 M phosphate buffer. The brains were cut on a cryostat into 40 µm sections and collected into 10 parallel series. Two of these series were stained with antibodies against glucocorticoid (GR) and mineralocorticoid (MR) receptors. One series from each brain was Nissl-stained for delineation of borders of the brain structures and evaluation of the number of cells in some of them. The number of hippocampal neurons and GRimmunopositive neurons in an area was estimated using the StereoInvestigator system (MicroBrightField Inc). Due to the crucial role of IL-6 in development of the hippocampus we evaluated the total number of cells in the CA1 field. We found that IL-6- deficient mice had significantly lower number of cells in the CA1 field and that almost all cells, unlike in wild-type mice, expressed the glucocorticoid receptor. Our preliminary results demonstrated that IL-6 is implicated in stress. Supported by the Polish National Science Center grant No 1577

10

Influence of forced treadmill and voluntary wheel running on the sensitivity of gastric mucosa to ulcerogenic stimuli in male rats

63%

Yarushkina N. I., Komkova O. P., Filaretova L. P.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 6

11

Dexamethasone effects on Bax expression in the mouse testicular germ cells

63%

Mahmoud H., Mahmoud O., Layasadat K., Naeim A.

Folia Histochemica et Cytobiologica

|

2009

|

tom 47

|

nr 2

237-241

12

11beta-hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats

63%

Koeva Y., Bakalska M., Atanassova N., Georgieva K., Davidoff M.

Folia Histochemica et Cytobiologica

|

2007

|

tom 45

|

nr 4

381-386

13

Adipose tissue tumor necrosis factor-alpha and interleukin-6 response to glucocorticoid treatment during inflammation

63%

Zubel-Lojek J., Oclon E., Latacz A., Pierzchala-Koziec K.

Folia Biologica

|

2016

|

tom 64

|

nr 3

14

Identification and tissue distribution of a novel rat glucocorticoid receptor splice variant

63%

Ju H., Wang X., Liu Z., Liu P., Zhao Y., Xiong R., Zhou Y., Chen X.

Acta Biochimica Polonica

|

2009

|

tom 56

|

nr 1

109-113

Glucocorticoid receptor (GR) is a steroid hormone receptor that has been shown to play important roles in diverse cellular and physiological processes. More and more evidence has revealed that the effects of glucocorticoids are mediated by the glucocorticoid receptor through genomic or nongenomic mechanisms. A growing number of glucocorticoid receptor splice variants have been identified in human tissues, but few are known in rat tissues. In this work, a novel rGR cDNA, called rGRβ, was cloned from Sprague Dawlay (SD) rat liver. Sequence analysis revealed that the rGRβ mRNA was 39 base pairs (bp) shorter than the rGR mRNA reported earlier. The deleted segment is located in exon 1 and encodes 13 repeated glutamine residues. Both the rGR and rGRβ mRNAs were quantitated by Northern blot hybridization using non-homologous glucocorticoid cDNA probes. Results showed that the rGR and rGRβ mRNAs were most abundant in the lung, the least abundant in the heart, and there were more rGR and rGRβ mRNAs in the kidney than in the liver. The identification of rGRβ may contribute to the understanding of the genomic or nongenomic effects of glucocorticoids.

15

Are baseline glucocorticoid levels linked to aggressive behaviour in wild wood mice?

63%

Hernandez M. C., Navarro-Castilla A., Pineiro A., Silvan G., Illera J. C., Barja I.

Polish Journal of Ecology

|

2020

|

tom 68

|

nr 1

16

Biphasic enhacement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils

63%

Strosznajder J., Chalimoniuk M.

Acta Neurobiologiae Experimentalis

|

1996

|

tom 56

|

nr 1

17

Studies of the DNA binding affinity of fetal rat liver nucleoproteins to the alpha 1-acid glycoprotein gene promotor

63%

Bogojevic D., Petrovic M., Sevaljevic L.

Folia Histochemica et Cytobiologica

|

1992

|

tom 30

|

nr 4

18

Cytokine, cytokine receptors and glucorticoid network controlling N-glycosylation of acute phase proteins in vitro

63%

Mackiewicz A.

Folia Histochemica et Cytobiologica

|

1992

|

tom 30

|

nr 4

19

Stress-induced rise in endothelaemia, von Willebrand factor and hypothalamic-pituitary-adrenocortical axis activation is reduced by pretreatment with pentoxifylline

63%

Jezova D., Kristova V., Slamova J., Mlynarik M., Pirnik Z., Kiss A., Kriska M.

Journal of Physiology and Pharmacology

|

2003

|

tom 54

|

nr 3

Stress is considered to be a risk factor of several diseases. The following hypotheses were tested: (1) single exposure to an intensive stressor is followed by endothelial stimulation and/or damage to endothelial cells, (2) potential stress-induced endothelial cell damage is reduced by repeated pretreatment with pentoxifylline and (3) pentoxifylline treatment modifies neuroendocrine activation during stress reflected by changes in hypothalamic-pituitary-adrenocortical (HPA) axis function. Rats were treated with saline or pentoxifylline (20 mg/kg, s.c.) once daily for 7 days and then exposed to single immobilization stress for 20 or 120 min. In saline pretreated rats, stress exposure was followed by a rise in endothelaemia, von Willebrand factor concentrations, adrenocorticotropic hormone (ACTH) and corticosterone release, as well as by enhanced gene expression of hypothalamic corticotropin releasing factor (CRH). Stress-induced changes were reduced by pretreatment with pentoxifylline. Significant inhibition was observed in endothelaemia, plasma ACTH and corticosterone concentration in the adrenals. Thus, signs of endothelial injury as well as stress-induced hormone levels were reduced by pretreatment with pentoxifylline, although there is no evidence for a causal relationship. This protective action of pentoxifylline might be of benefit in the prevention and therapy of some stress-related disorders.

20

The annexin-1 knockout mouse: what it tells us about the inflammatory response

63%

Roviezzo F., Getting S. J., Paul-Clark M. J., Yona S., Gavins F. N. E., Perretti M., Hannon R., Croxtall J. D., Buckingham J. C., Flower R. J.

Journal of Physiology and Pharmacology

|

2002

|

tom 53

|

nr 4,1

The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postulated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release. Immuno-neutralisation or antisense strategies support this hypothesis as they can reverse the effect of glucocorticoids in several systems. We recently generated a line of mice lacking the Anx-1 gene noting that some tissues taken from such animals exhibited an increased expression of several proteins including COX-2 and cPLA2. In models of experimental inflammation, Anx-1-/- mice exhibit an exaggerated response and a partial or complete resistance to the anti-inflammatory effects of glucocorticoids. Several other anomalies were noted including abnormal leukocyte adhesion molecule expression, an increased spontaneous migratory behaviour of PMN in Anx-1-/- mice and a resistance in Anx-1-/- macrophages to glucocorticoid inhibition of superoxide generation. This paper reviews these and other data in the light of the development of the ‚second messenger™ hypothesis of glucocorticoid action.

Ograniczanie wyników

Nanoparticles for targeted delivery of anticancer agents

Long-circulating liposomes for I.V. targeted delivery of glucocorticoids in arthritis

The overproduction of nitric oxide associated with neutrophilic predominance is relevant to airway mycotic infections in asthmatics undergoing prolonged glucocorticoid treatment

Plasma glucocorticoids and ACTH levels during different periods of activity in the European beaver (Castor fiber L.)

Prenatal glucocorticoids can programme postnatal development

Hormonal adaptation and the stress of exercise training: the role of glucocorticoids

Changes in glucocorticoid-induced apoptosis and in expression of Bcl-2 protein during long-term culture of thymic lymphoma

Suppression of mast cell activation by glucocorticoid

The role of interleukin 6 in stress response and anxiety-driven behavior in mice

Influence of forced treadmill and voluntary wheel running on the sensitivity of gastric mucosa to ulcerogenic stimuli in male rats

Dexamethasone effects on Bax expression in the mouse testicular germ cells

11beta-hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats

Adipose tissue tumor necrosis factor-alpha and interleukin-6 response to glucocorticoid treatment during inflammation

Identification and tissue distribution of a novel rat glucocorticoid receptor splice variant

Are baseline glucocorticoid levels linked to aggressive behaviour in wild wood mice?

Biphasic enhacement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils