Wyniki wyszukiwania

1

Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and PPI-resistant non-erosive reflux disease

100%

Zatorski H., Mosinska P., Storr M., Fichna J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 6

2

Nesfatin-1 protects from acute pancreatitis: role of melanocortin receptors

100%

Buzcu H., Ozbeyli D., Yuksel M., Cilingier Kaya O. T., Kasimay Cakir O.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 6

3

Preliminary results on exogenous ghrelin administration via stomach tube influence on the crypt cell proliferation in the small intestine mucosa of neonatal piglets

100%

Slupecka M., Wolinski J.

Journal of Animal and Feed Sciences

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2007

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tom 16

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nr 3

445-451

4

Ghrelin-immunoreactive cells in the gastrointestinal tract of hypertensive rats

100%

Janiuk I., Kaleczyc J., Kasacka I.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 4

5

The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats

100%

Kapica M., Laubitz D., Puzio I., Jankowska A., Zabielski R.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 4

Ghrelin, a 28 amino acids polypeptide was recognized as an endogenous ligand for the growth hormone secretagogue receptor. It turned out that the entire sequence of ghrelin is not necessary for performing the above-mentioned functions. It was suggested that 5 residues (Gly-Ser-Ser(n-octanoyl)-Phe, pentaghrelin) constituted functionally active part of the full-length polypeptide. Ghrelin-28 was found to inhibit pancreatic enzyme output in rats, though the effect of pentaghrelin was not studied so far. The study aimed to determine the involvement of pentaghrelin in pancreatic juice secretion in anaesthetized rats. Male Wistar rats (220 ± 20 g body weight, b. wt.) were anesthetized, the external jugular vein and common biliary-pancreatic duct were cannulated. Pentaghrelin boluses (iv, 1.2, 12, and 50 nmol kg-1 b. wt.) were injected every 30 min with or without CCK-8 infusion, duodenal mucosal CCK1 receptor blockade with tarazepide, vagotomy and capsaicin pretreatment. Pentaghrelin boluses reduced the volume of pancreatic-biliary juice, protein and trypsin outputs both under basal and CCK-8-stimulated conditions in a dose-dependent manner. However, exogenous pentaghrelin failed to affect the pancreatic secretion in rats subjected to vagotomy, capsaicin deactivation of afferents or pretreatment with Tarazepide. In conclusion, pentaghrelin may control exocrine pancreas secretion by affecting duodenal neurohormonal mechanism(s) involving CCK and vagal nerves in rats.

6

Ghrelin - a new gastroprotective factor in gastric mucosa

100%

Konturek P. C., Brzozowski T., Pajdo R., Nikiforuk A., Kwiecien S., Harsch I., Drozdowicz D., Hahn E. G., Konturek S. J.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 2

Ghrelin, a novel peptide expressed in the gastrointestinal tract, especially in the gastric mucosa, exerts several biological activities including the stimulation of appetite and food intake, the stimulation of intestinal motility and the release of growth hormone. The aim of this study was to examine the expression of ghrelin in gastric mucosa after its exposure to ethanol and its effects on gastric lesions induced by ethanol with and without pretreatment with indomethacin. Acute gastric lesions were induced by intragastric administration of 75% ethanol in rats pretreated with saline-vehicle or ghrelin injected intraperitoneally (i.p.) without or with i.p. pretreatment with indomethacin. At the end of experiments, the rats were anesthetized, the stomach was exposed to measure gastric blood flow (GBF), to determine the area of gastric lesions and to take biopsy samples from the oxyntic mucosa for determination of transcripts of ghrelin, tumor necrosis alpha (TNF-alpha) and transforming growth factor alpha (TGFalpha) using RT-PCR and to assess the generation of PGE2 by RIA. Exposure of gastric mucosa to 75% ethanol resulted in numerous mucosal lesions of an area of about 115 mm2 and in the increase of mucosal expression of TNF-alpha, PGE2, TGFalpha and ghrelin with concomitant decrease in GBF. Exogenous ghrelin reduced dose-dependently acute gastric lesions with simultaneous attenuation of GBF and a decrease in the expression of TNF-alpha but not TGFalpha. Pretreatment with indometahcin, which suppressed the generation of PGE2 by about 85%, augmented ethanol-induced gastric lesions and eliminated the ghrelin-induced protection of mucosa against ethanol. We conclude that ghrelin, whose mucosal expression is enhanced after exposure to ethanol, exhibits a strong gastroprotection, at least in part, due to its anti-inflammatory action mediated by prostaglandins.

7

Ghrelin attenuates the development of acute pancreatitis in rats

100%

Dembinski A., Warzecha Z., Ceranowicz P., Tomaszewska R., Stachura J., Konturek S. J., Konturek P. C.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

Ghrelin, a circulating growth hormone-releasing peptide isolated from human and rat stomach, stimulates growth hormone secretion, food intake and exhibits gastroprotective properties. Ghrelin is predominantly produced by a population of endocrine cells in the gastric mucosa, but its presence in bowel, pancreas, pituitary and hypothalamus has been reported. In human fetal pancreas, ghrelin is expressed in a prominent endocrine cell population. In adult pancreatic islets the population of these cell is reduced. The aim of present study was to investigate the influence of ghrelin administration on the development of acute pancreatitis. Methods: Acute pancreatitis was induced in rat by caerulein injection. Ghrelin was administrated twice (30 min prior to the first caerulein or saline injection and 3 h later) at the doses: 2, 10 or 20 nmol/kg. Immediately after cessation of caerulein or saline injections the following parameters were measured: pancreatic blood flow, plasma lipase activity, plasma interleukin-1ß (IL-1ß) and interleukin 10 (IL-10) concentration, pancreatic DNA synthesis, and morphological signs of pancreatitis. Results: Administration of ghrelin without induction of pancreatitis did not affect significantly any parameter tested. Caerulein led to the development of acute edematous pancreatitis. Treatment with ghrelin at the dose 2 nmol/kg, during induction of pancreatitis, was without effect on pancreatic histology or biochemical and functional parameters. Treatment with ghrelin at the dose 10 and 20 nmol/kg attenuated the development of pancreatitis and the effects of both doses were similar. Administration of ghrelin (10 or 20 nmol/kg) reduced inflammatory infiltration of pancreatic tissue and vacuolization of acinar cells. Also, plasma lipase activity and plasma IL-1ß concentration were reduced, and caerulein-induced fall in pancreatic DNA synthesis was reversed. Administration of ghrelin at the dose 10 and 20 nmol/kg was without effect on caerulein-induced pancreatic edema and pancreatitis-related fall in pancreatic blood flow. Conclusions: (1) Administration of ghrelin attenuates pancreatic damage in caerulein-induced pancreatitis; (2) Protective effect of ghrelin administration seems to be related the inhibition in inflammatory process and the reduction in liberation of pro-inflammatory IL-1ß.

8

Ghrelin accelerates the healing of oral ulcers in non-sialoadenectomized and in sialoadenectomized rats

84%

Warzecha Z., Kownacki P., Ceranowicz P., Dembinski M., Cieszkowski J., Dembinski A.

Journal of Physiology and Pharmacology

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2013

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tom 64

|

nr 5

9

Proinflammatory factors increased ghrelin synthesis and secretion in growing lambs

84%

Zubel J., Pierzchala-Koziec K., Oclon E., Fedorczak J.

Acta Biologica Cracoviensia. Series Zoologia

|

2009

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tom 51

33-37

10

Immunohistochemical analysis of ghrelin expression in various types of adrenal tumors

84%

Komarowska H., Malinska A., Komekbai Z., Brominska B., Bednarek-Rajewska K., Ruchala M., Rucinski M.

Folia Histochemica et Cytobiologica

|

2021

|

tom 59

|

nr 2

11

Alteration of peptidergic gut-brain signaling under conditions of obesity

84%

Kuhne S. G., Stengel A.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 5

12

Treatment with the ghrelin-O-acyltransferase (goat) inhibitor go-coa-tat reduces food intake by reducing meal frequency in rats

84%

Teuffel P., Wang L., Prinz P., Goebel-Stengel M., Scharner S., Kobelt P., Hofmann T., Rose M., Klapp B. F., Reeve J. R., Stengel A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 4

13

Changes in the content of major proteins and selected hormones in the blood serum of piglets during the early postnatal period

84%

Szymeczko R., Kapelanski W., Piotrowska A., Dybala J., Boguslawska-Tryk M., Burlikowska K., Hertig I., Sassek M., Pruszynska-Oszmalek E., Mackowiak P.

Folia Biologica

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2009

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tom 57

|

nr 1-2

97-103

14

Luminal sensing in the gut: an overview

84%

Dockray G. J.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

|

nr 4

9-17

The wall of the gut responds to an impressive array of signals originating in the lumen, including nutrient and non-nutrient chemicals, mechanical factors, and micro-organisms. The idea that the gut wall exhibits luminal chemo-sensitivity is implied in the original discovery of secretin by Bayliss and Starling, and has become an integral part of models of neurohumoral control of gastrointestinal function. Entero-endocrine cells are specialised for luminal nutrient sensing but sub-epithelial nerve fibres may also respond to luminal chemicals that freely diffuse across the epithelium eg short chain fatty acids. The molecular recognition mechanisms include G-protein coupled receptors (GPCRs) eg the extracellular Ca2+ sensing receptor which also responds to aromatic amino acids. There are also GPCRs sensing fatty acids, as well as bitter or noxious compounds. In addition, though, gating of ion channels including events secondary to energy availability eg ATP, may be involved in sensing some luminal chemicals. There is likely to be integration of luminal signals at several levels including at the level of entero-endocrine cells and at sub-epithelial nerve fibers. For example, the intestinal hormone CCK acts on primary afferent nerve fibers of the vagal trunk. The same fibers also express leptin receptors that are thought to respond to leptin released from gastric chief cells, orexin receptors (activation of which inhibits CCK) and possibly ghrelin receptors. Multiple signalling mechanisms allow specific responses to be matched to meals of differing content.

15

Resveratrol reduces excessive cholesterol accumulation in Goto-Kakizaki rat, a model with congenital type 2 diabetes

84%

Szkudelska K., Okulicz M., Szkudelski T.

Journal of Physiology and Pharmacology

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2020

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tom 71

|

nr 4

16

Effect of ghrelin and ration composition on milk output and feed intake in rabbits

84%

Kowalska D., Pietras M., Bielanski P.

Annals of Animal Science

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2011

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tom 11

|

nr 4

17

Cannabinoids enhance gastric X-A - like cells activity

84%

Zbucki R. L., Sawicki B., Hryniewicz A., Winnicka M. M.

Folia Histochemica et Cytobiologica

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2008

|

tom 46

|

nr 2

219-224

18

Involvement of cyclooxygenase-1 and cyclooxygenase-2 activity in the therapeutic effect of ghrelin in the course of ethanol-induced gastric ulcers in rats

84%

Warzecha Z., Ceranowicz P., Dembinski M., Cieszkowski J., Ginter G., Ptak-Belowska A., Dembinski A.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 1

19

Influence of preterm delivery on ghrelin and obestatin concentrations in maternal plasma, milk and their expression in mammary epithelial cells

84%

Slupecka-Ziemilska M., Wolinski J., Herman A. P., Romanowicz K., Dziegelewska Z., Borszewska-Kornacka M. K.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 5

20

A new set of endogenous reference genes for gene expression studies of porcine stomach

84%

Oczkowicz M., Rozycki M., Piorkowska K., Piestrzynska-Kajtoch A., Rejduch B.

Journal of Animal and Feed Sciences

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2010

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tom 19

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nr 4

Ograniczanie wyników

Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and PPI-resistant non-erosive reflux disease

Nesfatin-1 protects from acute pancreatitis: role of melanocortin receptors

Preliminary results on exogenous ghrelin administration via stomach tube influence on the crypt cell proliferation in the small intestine mucosa of neonatal piglets

Ghrelin-immunoreactive cells in the gastrointestinal tract of hypertensive rats

The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats

Ghrelin - a new gastroprotective factor in gastric mucosa

Ghrelin attenuates the development of acute pancreatitis in rats

Ghrelin accelerates the healing of oral ulcers in non-sialoadenectomized and in sialoadenectomized rats

Proinflammatory factors increased ghrelin synthesis and secretion in growing lambs

Immunohistochemical analysis of ghrelin expression in various types of adrenal tumors

Alteration of peptidergic gut-brain signaling under conditions of obesity

Treatment with the ghrelin-O-acyltransferase (goat) inhibitor go-coa-tat reduces food intake by reducing meal frequency in rats

Changes in the content of major proteins and selected hormones in the blood serum of piglets during the early postnatal period

Luminal sensing in the gut: an overview

Resveratrol reduces excessive cholesterol accumulation in Goto-Kakizaki rat, a model with congenital type 2 diabetes

Effect of ghrelin and ration composition on milk output and feed intake in rabbits