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  1. 3 Acta Microbiologica Polonica

  2. 3 Cellular and Molecular Biology Letters

  3. 2 Bulletin of the Veterinary Institute in Puławy

  4. 2 Folia Histochemica et Cytobiologica

  5. 2 Journal of Physiology and Pharmacology

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  1. 2 Doroszkiewicz W.

  2. 2 Dorotkiewicz-Jach A.

  3. 2 Drulis-Kawa Z.

  4. 2 Gubernator J.

  5. 2 Kozubek A.

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  1. 1 2019

  2. 1 2018

  3. 1 2016

  4. 1 2015

  5. 1 2014

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1

Glucose and glyoxal modify the diffusion of gentamicin through the peritoneal membrane in vitro

100%
Szary B., Czyzewska K., Grzelak T.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
2

Comparison of in vitro antibacterial activity of meropenem and gentamicin encapsulated in liposomes

100%
Drulis-Kawa Z., Gubernator J., Dorotkiewicz-Jach A., Doroszkiewicz W., Kozubek A.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.
3

Microscopic-electron examinations of the influence of the selected antibiotics on the secretory cells of the mammary gland

86%
Cegielski M.
Folia Histochemica et Cytobiologica
|
1986
|
tom 24
|
nr 4
4

Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity

86%
Kocaoglu S., Berkan T., Karan A., Basdemir G.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 2
5
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Content available

Evaluation of the developmental toxicity of gentamicin using postimplantation rat whole embryo culture

86%
Biernacki B., Wlodarczyk B., Minta M.
Bulletin of the Veterinary Institute in Puławy
|
2001
|
tom 45
|
nr 2
The embryotoxicity of gentamicin was evaluated with rat whole embryo culture (WEC) assay. Rat embryos displaying 1-3 somites were explanted on gestation day (GD) 9.5 and cultured for 48 h in rat serum. Gentamicin sulfate was added to the culture medium at a concentration of 1, 10 and 100 μg/ml. At the end of the cultivation five endpoints were evaluated for each viable embryo: yolk-sac diameter, crown-rump length, head length, somites number and morphological score. Gentamicin at the concentration of 100 μg/ml was embryotoxic and caused growth retardation in rat embryos. At the concentration of 10 μg/ml about 45% of embryos showed haematomas. The lowest dose of antibiotic (1 μg/ml) did not interfere with embryonic development in vitro.
6

Polymyxin B, gentamycin and neomycin inhibit phagocytic activity of Tetrahymena pyriformis

72%
Krawczynska W.
Acta Protozoologica
|
1990
|
tom 29
|
nr 3
7

Genetic translocation of resistance determinants in Staphylococcus aureus

72%
Mlynarczyk A., Mlynarczyk G., Grzesik A., Sawicka-Grzelak A., Lipnicki D., Dworczynski A., Osowiecki H.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1987
|
tom 35
|
nr 4-6
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Distribution and amount of cathepsin B in gentamicin-induced acute kidney injury in rats

72%
Svara T., Pogacnik M., Juntes P.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 1
75-82
The aim of our study was to investigate how the distribution and amount of cathepsin B change during acute kidney injury. The research was done on a rat model of acute kidney injury that was induced by nephrotoxic antibiotic gentamicin. Gentamicin was injected at a dose of 40 mg/kg body weight (the first treated group) and 80 mg/kg body weight (the second treated group) for 14 days. Control groups received injections of physiological saline only. One day after the last injection, animals were euthanized, dissected and kidney samples were taken and fixed in 10% buffered formalin. Tissue sections were stained with haematoxylin and eosin, periodic Acid Schiff (PAS) and Oil-red-O. Immunohistochemistry was used for the demonstration of cathepsin B. Vacuolar degeneration of the proximal convoluted tubules was the most prominent pathologic lesion found in the first treated group, while necrosis prevailed in the second treated group in the same localisation. In both treated groups significantly weaker immunohistochemical reaction for cathepsin B was noticed in the proximal convoluted tubules in comparison to the control groups (P < 0.05). The decrease of positive reaction was the largest in the proximal convoluted tubules of the outer renal cortex. Stronger positive reaction for cathepsin B, although not statistically significant, was found in the proximal straight tubules (P > 0.05), as well. However, more numerous cathepsin B-positive large granules appeared in the proximal straight tubules of the second treated group then in the second control group (P < 0.05). We can conclude that the amount of cathepsin B in the affected proximal convoluted tubules significantly decreases along the increased severity of the histopathological lesions of the proximal convoluted tubuls, the amount of enzyme in the well preserved proximal straight tubules increases and more cathepsin B-positive large granules appear in the cytoplasm.
9
Content available remote

The protective effects of zinc in experimental gentamicin induced acute renal failure in rats

72%
Teslariu O., Pasca A. S., Mititelu-Tartau L., Schiriac C. E., Gales C., Saftencu P. M., Nechifor M.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 5
10
Content available remote

Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis

72%
Galaly S. R., Ahmed O. M., Mahmoud A. M.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 6
11

Prevalence of high level aminoglycoside and vancomycin resistance among enterococci in Turkey

72%
Cirak M. Y., Sultan N.
Acta Microbiologica Polonica
|
1998
|
tom 47
|
nr 3
12

A study of purified pyocyanine produced by Pseudomonas aeruginosa: properties and grouping

72%
Al-Shibib A. S., Kandela S. A.
Acta Microbiologica Polonica
|
1993
|
tom 42
|
nr 3-4
13

A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin

72%
Drulis-Kawa Z., Gubernator J., Dorotkiewicz-Jach A., Doroszkiewicz W., Kozubek A.
Cellular and Molecular Biology Letters
|
2006
|
tom 11
|
nr 3
The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.
14

Effect of Sphaeranthus indicus ethanol extract on tissue antioxidant activity in gentamicin induced nephrotoxic rats

58%
Mathew J. E., Mantri A., Vachala S. D., Srinivasan K. K., Movaliya V.
Herba Polonica
|
2009
|
tom 55
|
nr 4
86-95
The purpose of the present study is to investigate whether the alcoholic extract of Sphaeranthus indicus could decrease the intensity of toxicity in albino rats. Gentamicin at a dose of 80mg/kg body weight was administered intraperitonially to albino male Wistar rats for 8 days. Then another set of animals were given the alcoholic extracts of S. indicus along with gentamicin treatment. The antioxidant levels, serum creatinine, serum urea etc were analyzed. The extracts could significantly decrease the gentamicin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney and liver tissues was also considerably reduced in S. indicus extract treated animals. The nephrotoxic rats showed lower activities of superoxide dismutase, catalase, glutathione transferase and reduced glutathione content in the liver and kidney which were restored to normal levels by treatment with S. indicus extract. The increased levels of lipid peroxidation in nephrotoxic rats were reverted back to normal levels after the treatment with S. indicus ethanol extract. These results suggest that it has protective effect against gentamicin induced nephrotoxicity which may be attributed to its antioxidant potential.
15

Emergence of high-level gentamicin resistance among Enterococci clinical isolates from burn patients in south-west of Iran: vancomycin still working

58%
Labibzadeh M., Kaydani G. A., Savari M., Ekrami A.
Polish Journal of Microbiology
|
2018
|
tom 67
|
nr 4
Enterococcus faecalis and Enterococcus faecium are among the main agents associated with nosocomial infections with high mortality in immunocompromised patients. Antibiotic resistance, especially against gentamicin and vancomycin among Enterococci, is a risk factor that could increase the morbidity and mortality rate. 179 Enterococci isolates from burn patients were included in this study. Antibiotic susceptibility testing was done using the disk diffusion test and minimum inhibitory concentration (MIC) was evaluated by agar microdilution. Vancomycin and gentamicin resistance associated genes including vanA, vanB, vanC, aac (6’)-Ie aph(2’’), aph(3’)-IIIa and ant(4’)-Ia were detected by PCR and their statistical relation with antibiotic resistance was evaluated. E. faecalis was the more prevalent strain among our local isolates and showed a higher antibiotic resistance in comparison to E. faecium. Vancomycin had a good antibacterial effect on the Enterococcus spp. isolates; however, resistance to this antibiotic and a high-level gentamicin resistance (HLGR) phenotype were observed. Among van operon genes, vanA was the most prevalent gene and among the gentamicin resistance genes, aph (3’)-IIIa was more frequent. The HLGR Enterococci are a real challenge in nosocomial infections. Vancomycin is a key antibiotic to treat such infections but emergence of VRE in our region could be a real concern and, therefore, phenotypic and molecular surveillance must be considered.
16

Tetracycline, erythromycin, and gentamicin resistance of Campylobacter jejuni and Campylobacter coli isolated from poultry in Poland

58%
Wozniak A., Wieliczko A.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 1
The aim of the research was the determination of resistance of 387 Campylobacter sp. strains isolated between 1994 and 1996 (broilers, laying hens) and 2005-2008 (broilers, laying hens, turkeys) to tetracycline, erythromycin, and gentamicin. The resistance was determined with the reference to minimum inhibitory concentration on the agar plates (MIC). Limit concentration value for tetracycline and gentamicin was measured at >8 µg/mL, while for erythromycin it was obtained at >16 µg/mL. Among the Campylobacter sp. isolates obtained in 2005-2008, tetracycline resistant strains were found, while the isolates obtained between 1994 and 1996 were tetracycline susceptible. An increase in the percentage of erythromycin intermediate susceptible strains from 2005- 2008 was reported in comparison to the isolates obtained in 1994-1996. Gentamicin susceptibility was found in 99.5% of all the Campylobacter sp. strains isolated between 1994 and 2008. These findings reveal a broad extent of antimicrobial resistance in Campylobacter isolates from poultry in Poland and underline the need for prudent use of antibiotics in poultry production to minimise the spread of antibiotic resistant Campylobacter strains.
17

Aminoglycosides resistance in clinical isolates of Staphylococcus aureus from a University Hospital in Bialystok, Poland

58%
Hauschild T., Sacha P., Wieczorek P., Zalewska M., Kaczynska K., Tryniszewska E.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 2
225-228
18
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Assessment of gentamicin effect on oxidoreductive balance and microstructure of trunk kidney in Prussian carp (Carassius gibelio)

58%
Bojarski B., Jakubiak M., Bien M., Batoryna M., Formicki G., Socha M., Drag-Kozak E., Tombarkiewicz B.
Annals of Warsaw University of Life Sciences - SGGW. Animal Science
|
2019
|
tom 58[2]
19

Antibiotic resistance of Campylobacter jejuni with reference to plasmid profiles of clinical and chicken isolates

58%
Lekowska-Kochaniak A., Rozynek E., Popowski J.
Acta Microbiologica Polonica
|
1996
|
tom 45
|
nr 3-4
20

Wplyw antybiotykow na eksplantaty truskawki w kulturach in vitro

44%
Kowalik M., Grodek M.
Progress in Plant Protection
|
2007
|
tom 47
|
nr 4
167-171
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