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Altered expression of adenosine receptors in heart of diabetic rat

100%

Grden M., Podgorska M., Szutowicz A., Pawelczyk T.

Journal of Physiology and Pharmacology

2005

tom 56

nr 4

Diabetes results in functional, biochemical, and morphological abnormalities in the heart. Some of these changes may be attributed to altered adenosine action. This study aimed to examine the expression level of adenosine receptors (AR) in heart of streptozotocin-induced diabetic rat. Performed analyses revealed detectable levels of A1-AR, A2a-AR, A2b-AR, A3-AR mRNA and protein in whole heart and isolated cardiac myocytes. An increase in A1-AR protein content with no changes in mRNA level was observed in isolated cardiac myocytes. Diabetes resulted in an increase of A3-AR mRNA and protein levels in heart and in cardiac myocytes. The level of A2a-AR mRNA was increased in whole diabetic heart, but it decreased in cardiac myocytes with no detectable changes in protein content. We did not observe any changes in expression level of A2b-AR in diabetic heart and isolated cardiac myocytes. Administration of insulin to diabetic rat for four days resulted in returning of the ARs mRNA and protein to the levels observed in heart of normal rat. These changes in ARs genes expression, and receptors protein content correspond to some abnormalities characteristic of the diabetic heart, suggesting involvement in pathogenesis of diabetic cardiomyopathy.

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome

80%

Smigielska-Kuzia J., Bockowski L., Sobaniec W., Sendrowski K., Zelazowska-Rutkowska B., Cholewa M.

Folia Histochemica et Cytobiologica

2010

tom 48

nr 4

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart

80%

Heather L. C., Catchpole A. F., Stuckey D. J., Cole M. A., Carr C. A., Clarke K.

Journal of Physiology and Pharmacology

2009

tom 60

nr 3

31-39

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg-1.day-1) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. Cardiac function at the base of the left ventricle was normal, but apical ejection fraction decreased from 90% to 31% and apical free wall thickening decreased by 94%, accompanied by increased fibrosis and inflammation. Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. Fatty acid transporter protein levels were 11-52% lower and triglyceride concentrations were 55% lower in isoproterenol-infused rat hearts. Basal glycolysis and glycogen concentration were not changed, yet insulin stimulated glycolysis was decreased by 32%, accompanied by 33% lower insulin stimulated glucose transporter, GLUT4, protein levels in rat hearts following isoproterenol infusion, compared with controls. In conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Folia Histochemica et Cytobiologica

1 Bockowski L.

1 Carr C. A.

1 Catchpole A. F.

1 Cholewa M.

1 Clarke K.

1 Cole M. A.

1 Grden M.

1 Heather L. C.

1 Pawelczyk T.

1 Podgorska M.

1 Sendrowski K.

1 Smigielska-Kuzia J.

1 Sobaniec W.

1 Stuckey D. J.

1 Szutowicz A.

1 Zelazowska-Rutkowska B.

1 2010

1 2009

1 2005

Wyniki wyszukiwania

Altered expression of adenosine receptors in heart of diabetic rat

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart