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Bioequivalence study of two formulations of enrofloxacin following oral administration in chickens

100%
Posyniak A., Zmudzki J., Niedzielska J., Biernacki B.
Bulletin of the Veterinary Institute in Puławy
|
2001
|
tom 45
|
nr 2
The aim of this study was to demonstrate the bioequivalence of two formulations base on enrofloxacin i.e. between a test formulation Enrofloksacyna 10% per os (Biowet Drwalew) and the reference Baytril 10% (Bayer), according to a framwork required for the registration files. Both formulations were administered in a single oral administration at the recommended dose of 10 mg enrofloxacin per kg of b.w. in chickens. The study was conducted following conventional design, blood samples were collected until 72 h after drug application and analysed by validated method. The plasma disposition kinetics of enrofloxacin in chickens was similar following treatment with both formulations Cmax values (0.92 and 0.98 μg/ml, respectively) and were achieved at the 2nd h after administration of both formulations. None of the estimated pharmacokinetic parameters of both drug formulations were statistically different. Findings show that Enrofloksacyna 10% per os is equivalent to reference Baytril 10%.
2

Effect of increasing doses of enrofloxacin on chicken articular cartilage

84%
Maslanka T., Jaroszewski J. J., Mikolajczyk A., Rotkiewicz T.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 1
Enrofloxacin is a synthetic chemotherapeutic agent from the class of the fluoroquinolones that is widely used to treat bacterial infections in animals. Fluoroquinolones cause severe lesions in articular-epiphyseal cartilage complexes of growing mammals. The aim of the present study was to determine whether enrofloxacin has chondrotoxic, dose- and time-dependent effects on avian articular cartilage. 21-day-old male broiler chickens were treated orally with a single or five doses of 10, 50, 100, 300 and 600 mg/kg/day of enrofloxacin. 24 hours after the last dose the animals were killed and femoral head with condyles and tibial condyles were subject to a gross and histopathological investigation. The lesion scoring system was used to determine the progression of lesions. The mean score in birds treated with a single dose of 300 and 600 mg/kg of enrofloxacin was significantly increased when compared to the control group, while the administration of one dose of 10, 50 and 100 mg/kg of the drug did not cause substantial changes in the examined articular cartilages. The mean score was significantly greater in birds dosed for 5 days with 50, 100, 300 or 600 mg/kg/day of enrofloxacin when compared to the control group. Histologic changes included, among others, occurrence of chondrocytes with shrunken cytoplasm and pyknotic nuclei, spindle-shaped cells, clusters of chondrocytes and loss of proteoglycan. In conclusions, our results indicate that the use of enrofloxacin in growing chickens at recommended dosage is safe from the point of view of possibility of chondrotoxic effect. Only very high dosage of enrofloxacin, significantly exceeding the therapeutically applied doses, can induce toxic effects in articular cartilage and intensity of chondrotoxicity is dose- and time-dependent. Moreover, our findings suggest that quinolone-induced arthropathy is considerably less expressed in birds than in mammals.
3

Effect of long-term treatment with therapeutic doses of enrofloxacin on chicken articular cartilage

84%
Maslanka T., Jaroszewski J. J.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 3
Quinolone-induced arthropathy has been observed after a single very large dose, or after several moderately large doses in juvenile animals of multiple species. The purpose of the present study was to determine whether long-term treatment with therapeutic doses of enrofloxacin has a detrimental effect on chicken articular cartilage. 21-day-old broiler chickens were treated orally with 10 mg/kg/day of enrofloxacin for 10, 20 and 35 days. 24 hours after the last dose, the animals were killed and the femoral head with condyles and tibial condyles were subjected to a gross and histopathological investigation. The necropsy did not reveal macroscopic visible pathological changes in the articular cartilage surface, as well as in soft tissues surrounding joints in any of the animals from this study. Also, light microscopy evaluation did not show significant histopathological changes in any of the specimens from either experimental and control animals. In conclusion, our results indicate that treatment with a therapeutic dose of enrofloxacin for a period exceeding the recommended duration of therapy does not cause arthropathy in growing chickens. Moreover, the results obtained seem to indicate that chondrotoxicity of quinolones does not have a cumulative nature.
4

Antybiotykoterapia u świń cz.5. Charakterystyka fluorochinolonów

67%
Pomorska-Mol M.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
|
2015
|
tom 10
|
nr 3
5

Influence of enrofloxacin and chloramphenicol on the level of IgY in serum and egg yolk after immunostimulation of hens with Salmonella enteritidis antigens

67%
Tokarzewski S.
Polish Journal of Veterinary Sciences
|
2002
|
tom 05
|
nr 3
6

Leczenie zapalenia uszu u psów. Tak wiele możliwości - którą wybrać?

43%
Cole L.
Weterynaria po Dyplomie
|
2019
|
tom 20
|
nr 5
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