The aim of study was estimate the effects of acetazolamid administration on arterial acid-base equilibrium and electrolyte concentrations and electrocardiograms in dogs. The study was carried out on 10 mixed-breed dogs, which were administered acetazolamid over 3 days in doses of 30 mg/kg b.w. twice a day. Administration of acetazolamid caused a decrease in pH levels, partial pressure of carbon oxide, bicarbonates in the blood and ions of potassium in the serum. An increase of chloride and sodium concentration in serum was also observed. These results indicate hypochloremic metabolic acidosis associated with hypokalemia. Electrocardiography recordings in the examined dogs were abnormal. Prolonged QT intervals, depression of ST segments and the appearance of a paroxysmal, polymorphous type of ventricular tachycardia were also recorded.
Fish exposed to 200 and 300 μg/1 PCB′s (Aroclor 1242) for 24 hr demonstrates negative chronotropic effect; increase in the duration of segments and intervals as well as the waves amplitude. A tachycardia was also observed during the experiments. On the other hand, bioaccumulation of PCB′s in the eel fish was depended upon the concentration and time, the level of PCB′s in the liver was significantly higher than the level observed in the other tissues. Also, the descending order of PCB′s accumulated after 24 hr was found in the gills, blood, kidney, liver and muscle, respectively.