Wyniki wyszukiwania

1

Cyclin-dependent kinase inhibitor olomoucine II interacts with CDK2 and CDK9

100%

Krystof V., Orsag M., Paprskarova M., Muller P., Vojtesek B., Strnad M.

Cellular and Molecular Biology Letters

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2005

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tom 10

|

nr Suppl.2

2

Structural studies on CDK2-inhibitor complexes

88%

Endicott J.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 3

3

Exploiting structural principles to generate protein kinase inhibitors

88%

Noble M., Barrett P., Endicott J., Johnson L., McDonnell J., Pratt D., Robertson G.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

4

The selectivity of pharmacological inhibitors of cyclin-dependent kinases [CDKS] and glycogen synthase kinase-3 [GSK-3]

88%

Meijer L.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

5

Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential

75%

Wesierska-Gadek J., Brzoza A., Komina O., Maurer M.

Acta Biochimica Polonica

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2009

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tom 56

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nr 3

495-501

Increased expression and activity of proteins driving cell cycle progression as well as inactivation of endogenous inhibitors of cyclin-dependent kinases (CDKs) enhance the proliferative potential of cells. Escape of cells during malignant transformation from the proper cell cycle control rendering them independent from growth factors provides rationale for therapeutic targeting of CDKs. Exposure of rapidly growing human MCF-7 breast cancer and HeLa cervix cancer cells to roscovitine (ROSC), a selective inhibitor of CDKs, inhibits their proliferation by induction of cell cycle arrest and/or apoptosis. The outcome strongly depends on the intrinsic traits of the tumor cells, on their cell cycle status prior to the onset of treatment and also on ROSC concentration. At lower dose ROSC primarily inhibits the cell cycle-related CDKs resulting in a strong cell cycle arrest. Interestingly, ROSC arrests asynchronously growing cells at the G2/M transition irrespective of the status of their restriction checkpoint. However, the exposure of cancer cells synchronized after serum starvation in the late G1 phase results in a transient G1 arrest only in cells displaying the intact G1/S checkpoint. At higher dosage ROSC triggers apoptosis. In HeLa cells inhibition of the activity of CDK7 and, in consequence, that of RNA polymerase II is a major event that facilitates the initiation of caspase-dependent apoptosis. In contrast, in the caspase-3-deficient MCF-7 breast cancer cells ROSC induces apoptosis by a p53-dependent pathway. HIPK2-mediated activation of the p53 transcription factor by phosphorylation at Ser46 results in upregulation of p53AIP1 protein. This protein after de novo synthesis and translocation into the mitochondria promotes depolarization of the mitochondrial membrane.

6

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Arabidopsis cyclin-dependent kinase gene CDKG;2 is involved in organogenic responses induced in vitro

75%

Zabicki P., Kuta E., Tuleja M., Rataj K., Malec P.

Acta Biologica Cracoviensia. Series Botanica

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2013

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tom 55

|

nr 1

The Arabidopsis CDKG;2 gene encodes a putative cyclin-dependent Ser/Thr protein kinase of unknown biological function. This gene shows structural similarity to animal and human cyclin-dependent (PITSLRE) kinases. This study used the homozygous knockout cdkg;2 mutant based on T-DNA insertional line SALK_090262 to study the effect of mutation of the CDKG;2 gene on explant response and in vitro plant regeneration. For callus induction and proliferation, hypocotyls and cotyledons of 3-day-old seedlings of cdkg;2 and A. thaliana ecotype Col-0 were cultured on solid MS medium supplemented with 2,4-D (2 mg l-1). Organogenesis was induced after callus transfer on MS + TDZ (0.5 mg l-1). The initiation time of callus and shoot induction differed between the mutant and control cultures. Shoot regeneration after callus transfer on MS + TDZ was delayed in cdkg;2 (31 days versus 7 days in Col- 0). Shoots formed on callus derived from Col-0 hypocotyls but not on cotyledon-derived callus; in cdkg;2, shoots developed on both callus types. Mutant shoots did not form roots, regenerants were dwarfed, and inflorescences had small bud-like flowers with a reduced corolla and generative organs. Abnormalities observed during cdkg;2 organogenesis suggest a role of CDKG;2 as a regulator of adventitious root initiation.

7

Strategies for the discovery of novel inhibitors of cyclin-dependent kinases

75%

Zaharevitz D., Gussio R., Meijer L., Leost M., Kunick C., Schultz C., Senderowicz A., Lahusen T., Sausville E.

Cellular and Molecular Biology Letters

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1998

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tom 03

|

nr 3

8

Antimitotic properties of plant hormone-derived inhibitors of cyclin-dependent kinases in plant and animal cells

75%

Strnad M., Hajduch M., Havlicek L., Binarova P., Bogre L.

Cellular and Molecular Biology Letters

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1998

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tom 03

|

nr 3

9

Cell cycle regulating cyclin-dependent kinases as molecular targets in screening for new anti-mitotic agents

75%

Meijer L., Leclerc S., Leost M.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 3

10

Regulation of plant cyclin-dependent kinases and cell cycle machinery by plant hormone analogues

75%

Krystof V., Bogre L., Binarova P., Dolezel J., Strnad M.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 3

11

Inhibitors of cyclin dependent protein kinases

75%

Fabbro D., Woods-Cook K., Solf R., Meyer T., Mett H., Geiger T., Furet P., Zimmermann J., Ruetz S.

Cellular and Molecular Biology Letters

|

1998

|

tom 03

|

nr 3

12

Dynamics of human CDK2 and CDK5 studied by computer simulations

75%

Otyepka M., Bartova I., Kriz Z., Koca J.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

13

Tetrasubstituted purines as inhibitors of CDK1

75%

Moravec J., Havlicek L., Moravcova D., Hanus J., Fuksova K., Otyepka M., Krystof V., Strnad M.

Cellular and Molecular Biology Letters

|

2003

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tom 08

|

nr 2A

14

Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication

75%

Schang L. M.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

15

Trisubstituted purines as inhibitors of cyclin dependent kinase p34cdc2

75%

Krystof V., Havlicek L., Vesely J., Hajduch M., Strnad M.

Cellular and Molecular Biology Letters

|

1998

|

tom 03

|

nr 3

16

Control of the cell cycle progression

75%

Grabarek J.

Biotechnologia

|

1998

|

nr 3

17

The effect of cadmium on cell cycle control in suspension culture cells of soybean

75%

Sobkowiak R., Deckert J.

Acta Physiologiae Plantarum

|

2004

|

tom 26

|

nr 3

18

Expression of the p16 at mRNA and protein levels in B-cell lymphocytes

75%

Mizerski G., Antosz H., Jargiello M., Dudzisz-Sledz M.

Bulletin of the Veterinary Institute in Puławy. Supplement

|

2002

19

Pharmacological inhibitors of cyclin-dependent kinases [CDKs] and glycogen synthase kinase-3 [GSK-3]

75%

Meijer L.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

20

Inhibition of c-JUN-JNK and MLK pathway activation blocks DNA damage-induced death in embryonic cortical neurons

75%

Ghahremani M. H., Keramaris E., Bazenet C., Ham J., Slack R. S., Park D. S.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

Ograniczanie wyników

Cyclin-dependent kinase inhibitor olomoucine II interacts with CDK2 and CDK9

Structural studies on CDK2-inhibitor complexes

Exploiting structural principles to generate protein kinase inhibitors

The selectivity of pharmacological inhibitors of cyclin-dependent kinases [CDKS] and glycogen synthase kinase-3 [GSK-3]

Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential

Arabidopsis cyclin-dependent kinase gene CDKG;2 is involved in organogenic responses induced in vitro

Strategies for the discovery of novel inhibitors of cyclin-dependent kinases

Antimitotic properties of plant hormone-derived inhibitors of cyclin-dependent kinases in plant and animal cells

Cell cycle regulating cyclin-dependent kinases as molecular targets in screening for new anti-mitotic agents

Regulation of plant cyclin-dependent kinases and cell cycle machinery by plant hormone analogues

Inhibitors of cyclin dependent protein kinases

Dynamics of human CDK2 and CDK5 studied by computer simulations

Tetrasubstituted purines as inhibitors of CDK1

Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication

Trisubstituted purines as inhibitors of cyclin dependent kinase p34cdc2

Control of the cell cycle progression

The effect of cadmium on cell cycle control in suspension culture cells of soybean

Expression of the p16 at mRNA and protein levels in B-cell lymphocytes

Pharmacological inhibitors of cyclin-dependent kinases [CDKs] and glycogen synthase kinase-3 [GSK-3]

Inhibition of c-JUN-JNK and MLK pathway activation blocks DNA damage-induced death in embryonic cortical neurons