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Neuroleptics modulate cytokine and reactive oxygen species production in blood leucocytes of healthy volunteers

100%

Szuster-Ciesielska A., Slotwinska M., Stachura A., Marmurowska-Michalowska H., Kandefer-Szerszen M.

Archivum Immunologiae et Therapiae Experimentalis

2004

tom 52

nr 1

The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT1A, 5-HT2 and 5-HT4 receptors in rat frontal cortex

100%

Zahorodna A., Bobula B., Grzegorzewska M., Tokarski K., Hess G.

Journal of Physiology and Pharmacology

2004

tom 55

nr 2

The effects of a repeated treatment with antipsychotic drugs, clozapine and haloperidol, on the modulation of network activity ex vivo by 5-HT receptors were examined in rat frontal cortical slices using extracellular recording. Rats were treated for 21 days with clozapine (30 mg/kg p.o.), or haloperidol (1 mg/kg p.o.). Spontaneous bursting activity was induced in slices prepared 3 days after the last drug administration by perfusion with a medium devoid of Mg2+ ions and with added picrotoxin (30 mM). The application of 2-3 µM 8-OH-DPAT, acting through 5-HT1A receptors, resulted in a reversible decrease of bursting frequency. In the presence of 1 µM DOI, the 5-HT2 agonist, or 5 µM zacopride, the 5-HT4 agonist, bursting frequency increased. Chronic clozapine treatment resulted in an attenuation of the effect of the activation of 5-HT2 receptors, while the effects related to 5-HT1A and 5-HT4 receptor activation were unchanged. Treatment with haloperidol did not influence the reactivity to the activation of any of the three 5-HT receptor subtypes. These data are consistent with earlier findings demonstrating a selective downregulation of 5-HT2A receptors by clozapine and indicate that chronic clozapine selectively attenuates the 5-HT-mediated excitation in neuronal circuitry of the frontal cortex while leaving the 5-HT-mediated inhibition intact.

Neuropeptide Y [NPY] and its mRNA in discrete brain areas after subchronic administration of neuroleptics

80%

Herman Z. S.

Acta Neurobiologiae Experimentalis

1996

tom 56

nr 1

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Bobula B.

1 Grzegorzewska M.

1 Herman Z. S.

1 Hess G.

1 Kandefer-Szerszen M.

1 Marmurowska-Michalowska H.

1 Slotwinska M.

1 Stachura A.

1 Szuster-Ciesielska A.

1 Tokarski K.

1 Zahorodna A.

2 2004

1 1996

Wyniki wyszukiwania

Neuroleptics modulate cytokine and reactive oxygen species production in blood leucocytes of healthy volunteers

The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT1A, 5-HT2 and 5-HT4 receptors in rat frontal cortex

Neuropeptide Y [NPY] and its mRNA in discrete brain areas after subchronic administration of neuroleptics