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Content available

Importance of behavioral changes in identification of chronic pain and its causes in dogs – case report

100%
Karpinski M., Alchimowicz K., Wojtas J., Lojszczyk A., Garbiec A.
Acta Scientiarum Polonorum. Zootechnica
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2021
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tom 20
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nr 1
2

The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1beta induced inflammation in in vitro osteoarthritis model by regulating PI3K/AKT pathways

86%
Wu J.-R., Zhong W.-J., Chen Z.-D., Zhu B.-Q., Jiang Y.-Y., Wierzbicki P. M.
Folia Histochemica et Cytobiologica
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2020
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tom 58
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nr 4
3

Learning, memory and cortical plasticity

86%
Flor H.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
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nr 5
4
Content available remote

Assessment of analgesic effects of different initial doses of transdermal buprenorphine in the treatment of chronic pain in the elderly diagnosed with osteoarthritis

86%
Widenka M., Leppert W.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 5
5
Content available remote

Peripheral mechanisms of intestinal dysmotility in the morphine tolerant and dependent rats

86%
Banach T., Zurowski D., Gil K., Weisbrodt N. W., Rosenfeld G., Thor P. J.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 1
Changes of intestinal motility and transit produced by tolerance to and dependence upon morphine have been partly attributed to peripheral mechanisms. We evaluated the effect of chronic peripheral morphine administration and peripheral µ-receptor blockade on vagal afferent activity (VAA) and c-Kit positive intramuscular cells of Cajal (ICCs). Ten rats were subjected to chronic subcutaneous morphine infusion for 72 h with subsequent VAA recording. Potential frequency was evaluated within recordings before and after µ receptor blockade by D-Phe -Cys -Tyr -D-Trp -Orn -Thr -Phe -Thr (CTOP) i.p. injections. Afterwards the rats were sacrificed and intramuscular c-Kit antigen expression was assessed by image analysis within removed fragments of duodenum and ascending colon. An equal group of rats served as a control for VAA and c-Kit expression. Analysis of VAA revealed similar frequencies of potentials in morphine tolerant / dependent rats before CTOP and in the controls. CTOP increased potential frequency in the morphine group which effect was visible mostly within the first 20 minutes (p=0.01). The morphine infused animals presented also higher c-Kit expression in both the duodenum (p<0.001) and the ascending colon (p<0.001) in comparison to the control group. Results of our study may indicate the involment of both the intestinal wall and the long vago-vagal reflexes in tolerance to and dependence upon opioids.
6
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Ongoing pain in streptozotocin model of diabetes in the rat: correlation with cutaneous chemonociception

72%
Gao Z., Wei H., Chen Z., Jalava N., Koivisto A., Petrovaara A.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 6
7

The morphology of lumbar sympathetic trunk in humans: a cadaveric study

72%
Gandhi K. R., Verma V. K., Chavan S. K., Joshi S. D., Joshi S. S.
Folia Morphologica
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2013
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tom 72
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nr 3
The vasospastic diseases and chronic pain related to lower limb have been successfully treated by surgical ablation of lumbar sympathetic trunk for last 80 years. Precise knowledge of anatomy of lumbar sympathetic trunk and its adjoining structures is mandatory for safe and uncomplicated lumbar and spinal surgeries. We aim to study the detailed anatomy of entry and exit of lumbar sympathetic trunk, the number, dimensions and location of lumbar ganglia in relation to lumbar vertebra. Thorough dissection was carried out in 30 formalin embalmed cadavers available in the Department of Anatomy, Pravara Institute of Medical Sciences (PIMS), Rural Medical College (RMC), Loni, Maharashtra. A total of 238 ganglia were observed in 60 lumbar sympathetic trunks. The sympathetic trunk traversed dorsal to the crus of diaphragm in 72.6% and in 13.3% it entered dorsal to the medial arcuate ligament. The most common site of the location of lumbar ganglia was in relation to the second lumbar vertebra, sometimes extending up to the L2–L3 vertebral disc. There was a medial shift of sympathetic trunk in lumbar region and it coursed over sacral promontory to reach the pelvic region in 96% of specimens. These variations should be kept in mind in order to prevent hazardous complications like accidental avulsion of first lumbar ganglia and genitofemoral neuritis. (Folia Morphol 2013; 72, 3: 217–222)
8

The role of microglia cells activation in the effects of opioids

58%
Popiolek-Barczyk K., Rojewska E., Zychowska M., Makuch V., Przewlocka B., Mika J.
Acta Neurobiologiae Experimentalis
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2013
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tom 73
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nr 1
Development of neuropathic pain is accompanied by many changes in immune and glial cells. These changes correspond to activation of immune and glial cells that have been shown to influence the opioid effectiveness and can be modulated by minocycline (a potent inhibitor of microglial activation). In earlier study we have demonstrated that function of opioidergic neurons may be modulated by the immune system. These changes have been shown to be responsible for the efficacy of opioids. The aim of our study was to examine the effect of the minocycline-triggered inhibition of microglia activation on the injury-induced changes and the efficacy of mu and delta opioid receptor ligands in a rat model of neuropathic pain (chronic constriction injury to the sciatic nerve). In cell culture studies, we examined the influence of opioids (morphine, DAMGO, DPDPE, deltorphin II) on activated primary cultured rat microglia by using MTT and/or NO assays. All experiments were performed according to the IASP recommendations and were approved by a local Bioethics Committee. On the spinal cord level the injury to the sciatic nerve induced an up-regulation of IL-1beta, IL-6 expression, CX3CR1 and C1q (marker of microglia, macrophage and leukocyte activation). Chronic administration of minocycline not only diminished neuropathic pain-related behavior and C1q-positive cell activation, but also attenuate the changes in proinflammatory factors like IL1beta, IL-6 and CX3CR1 in the spinal cord and DRG. In in vivo experiments, the analgesic effects of mu-opioid (morphine and DAMGO), but not delta-opioid (DPDPE, deltorphin II) receptor ligands were lower in the rats under neuropathic pain. Moreover, the analgesic effects of morphine and DAMGO, but not DPDPE and deltorphin II were significantly potentiated by minocycline chronic administration. Our in vitro findings that non-stimulated microglia cells respond differently to opioids in comparisons with stimulated cells as measured by MTT and/or NO assays, corresponded well with the results of in vivo studies. Our study underlined that inhibition of microglial activation could differently influence analgesic effects of mu- but not delta-opioid ligands in injury-induced pathologies, which may influence the effect of various opioid drugs used in chronic pain therapy.
9
Content available remote

Systemically active human opiorphin is a potent yet non-addictive analgesic without drug tolerance effects

58%
Rougeot C., Robert F., Menz L., Bisson J.-F., Messaoudi M.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 4
483-490
Human opiorphin QRFSR-peptide protects enkephalins from degradation by human neutral endopeptidase (hNEP) and aminopeptidase-N (hAP-N) and inhibits pain perception in a behavioral model of mechanical acute pain (1). Here, using two other pain rat models, the tail-flick and the formalin tests, we assess the potency and duration of the antinociceptive action of opiorphin with reference to morphine. The occurrence of adverse effects with emphasis on the side-effect profile at equi-analgesic doses was compared. We demonstrate that opiorphin elicits minimal adverse morphine-associated effects, at doses (1-2 mg/kg, i.v.) that produce a comparable analgesic potency in both spinally controlled thermal-induced acute and peripheral chemical-induced tonic nociception. The analgesic response induced by opiorphin in the formalin-induced pain model preferentially requires activation of endogenous µ-opioid pathways. However, in contrast to exogenous µ-opioid agonists such as morphine, opiorphin, does not develop significant abuse liability or antinociceptive drug tolerance after subchronic treatment. In addition, anti-peristaltism was not observed. We conclude that opiorphin, by inhibiting the destruction of endogenous enkephalins, which are released according to the painful stimulus, activates restricted opioid pathways specifically involved in pain control, thus contributing to a greater balance between analgesia and side-effects than found with morphine. Therefore, opiorphin could give rise to new analgesics endowed with potencies similar to morphine but with fewer adverse effects than opioid agonists. Its chemical optimization, to generate functional derivatives endowed with better bioavailability properties than the native peptide, could lead to a potent class of physiological type analgesics.
10
Content available remote

The role of oligodendrocytes in chronic pain: cellular and molecular mechanisms

58%
Malta I., Moraes T., Rodrigues G., Franco P., Galdino G.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 5
11

Zwalczanie bólu i zapalenia - coś więcej niż tylko NLPZ

44%
Downing R.
Weterynaria po Dyplomie
|
2019
|
tom 20
|
nr 4
12

Choroby stawów u kotów - przygotuj się na najgorsze i lecz najlepiej, jak się da!

37%
Dowdy S. M.
Weterynaria po Dyplomie
|
2020
|
tom 21
|
nr 5
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