Wyniki wyszukiwania

1

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

100%

Brozmanova M., Calkovsky V., Plevkova J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 3

23-30

Allergic rhinitis is a common cause of chronic cough. Topical corticosteroids are regarded as the most effective first-time treatment in allergic rhinitis. In this study we evaluated the cough sensitivity during the early and late allergic responses in guinea pigs with experimental allergic rhinitis. Another aim of the study was to follow up the effect of inhaled beclomethasone dipropionate on the cough in guinea pigs with allergic rhinitis. 31 guinea pigs were sensitized with ovalbumin (OA). Animals were intranasally challenged with OA (experiment) or saline (control) in 7-day intervals for 9 weeks. Cough was induced by inhalation of citric acid aerosols in gradually increasing concentrations for 30 s and was evaluated 1 h after the 8th nasal challenge (NCH) and 17 h after the 9th NCH. Cough was significantly increased only during an early allergic response, 1 h after repeated NCH [18 (14-23) vs. 8 (3-10); P<0.001]. Five experimental animals were inhaling aerosol of beclomethasone dipropionate seven days between the 8th and the 9th NCH and cough was evaluated 1 h after the 9th NCH. Inhaled corticosteroids significantly inhibited the enhanced allergic rhinitis related cough [4 (1-9) vs.19 (9-37) vs. 6 (3-9); P<0.05].

2

Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers

100%

Plevkova J., Brozmanova M., Pecova R., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 3

101-106

Rhinosinusitis is the most common cause of chronic cough. There is clinical experience that cough can be elicited from lower airways including the larynx. However, there is no experimental evidence, that afferent nerve endings localized in the nose or sinuses can directly mediate the cough reflex. Stimulation of nasal afferents affects breathing pattern (apnea) and bronchial smooth muscles (nasobronchial reflex). The question arises of whether stimulation of nasal afferents could also interfere with the cough reflex. Intranasal capsaicin enhances the cough response in cats and guinea pigs. In the present study we address the problem of modulation of the cough response by intranasal capsaicin challenge in humans. Twelve healthy volunteers were recruited for the study. The effect of intranasal capsaicin (25µl, 750µM) and the airway cough threshold were determined at the start of the experiment. After that, cough response was provoked by inhalation of a tussigen during stimulation of nasal afferents with capsaicin and in control conditions in a randomized order. The cough response provoked during intranasal capsaicin was significantly enhanced compared with that during control conditions. Thus, the result was similar to that obtained in previous animal studies. The enhancement of the cough response could be explained by a facilitating interaction between the afferent information of nasal origin and the central neuronal network responsible for creation of cough pattern.

3

Does the established cause of chronic cough depend on diagnostic approach?

100%

Grabczak E. M., Dabrowska M., Krenke R., Domeracka-Kolodziej A., Domagala-Kulawik J., Arcimowicz M., Hamera M., Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

285-296

4

Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

84%

Brozmanova M., Plevkova J., Tatar M., Kollarik M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

153-161

5

Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs

84%

Plevkova J., Antosiewicz J., Verechova S., Poliacek I., Jakus J., Tatar M., Pokorski M.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

89-93

In the present study we investigated the possibility of central convergence of neural pathways coming from distant anatomical regions in modulating the cough response. We addressed this issue by inducing cough from the tracheo-bronchial region on the background of capsaicin-stimulated and mesocain-blocked nasal mucosa in 14 anesthetized guinea pigs. The control group consisted of 6 guinea pigs in which the active agents, capsaicin and mesocain, were substituted for by inert physiological saline. All animals were tracheostomized, and the larynx was disconnected from the proximal part of the trachea with preserved innervations, and all were subjected to the same protocol. Cough, induced by mechanical irritation of the tracheo-bronchial mucosa, was elicited three times: in the control condition, after intranasal capsaicin challenge, and after another capsaicin challenge preceded by intranasal instillation of a local anesthetic, mesocain. The main finding of the study was that the number of cough efforts per bout, assessed from positive deflections on the intrapleural pressure recordings, was significantly enhanced by intranasal capsaicin challenge and this effect was reversed by intranasal pretreatment with the anesthetic mesocain [2.1 ±0.2 (control) vs. 3.5 ±0.4 (capsaicin) vs. 2.2 ±0.2 (capsaicin after mesocain) (P<0.01)], with no appreciable changes in the magnitude of cough efforts. The cough response in the control group remained unchanged. We conclude that tracheo-bronchial cough may be modified by neural sensory input to the brain coming from nasal mucosa. Therefore, cough reflex is subject to central convergence of peripheral neural pathways originating at distant anatomical locations.

6

Evaluation of the cough reflex and airway reactivity in toluene- and ovalbumin-induced airway hyperresponsiveness

84%

Mokry J., Nosalova G.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

7

Excitability and rhythmicity of tracheobronchial cough is altered by aspiration reflex in cats

67%

Poliacek I., Jakus J., Simera M., Barani H., Visnovcova N., Halasova E., Tomori Z.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 5

8

Spojrzenie polskiego lekarza weterynarii

67%

Niziolek R.

Weterynaria po Dyplomie

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2020

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tom 21

|

nr 1

9

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

67%

Varechova S., Plevkova J., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

719-726

10

Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs

67%

Brozmanova M., Bartos L., Plank L., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

11

Ocena i postępowanie w przypadku przewlekłego kaszlu u psów

43%

Hulsebosch S., Johnson L. R.

Weterynaria po Dyplomie

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2020

|

tom 21

|

nr 1

Ograniczanie wyników

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers

Does the established cause of chronic cough depend on diagnostic approach?

Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis

Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs

Evaluation of the cough reflex and airway reactivity in toluene- and ovalbumin-induced airway hyperresponsiveness

Excitability and rhythmicity of tracheobronchial cough is altered by aspiration reflex in cats

Spojrzenie polskiego lekarza weterynarii

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs

Ocena i postępowanie w przypadku przewlekłego kaszlu u psów