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  1. 2 Acta Biochimica Polonica

  2. 2 Archivum Immunologiae et Therapiae Experimentalis

  3. 2 Bulletin of the Polish Academy of Sciences. Biological Sciences

  4. 2 Cellular and Molecular Biology Letters

  5. 2 Folia Histochemica et Cytobiologica

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  1. 1 Arakawa T.

  2. 1 Bartsch M.

  3. 1 Blach-Olszewska Z.

  4. 1 Bozko P.

  5. 1 Butruk E.

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  1. 1 2010

  2. 1 2009

  3. 1 2007

  4. 1 2006

  5. 1 2005

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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Inhibitory effects of indomethacin on growth and proliferation of gastric carcinoma cells Kato III

100%
Fujiwara Y., Tarnawski A., Fujiwara K., Arakawa T., Kobayashi K.
Journal of Physiology and Pharmacology
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1993
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tom 44
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nr 2
2

Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status

100%
Bozko P., Larsen A. K., Raymond E., Skladanowski A.
Acta Biochimica Polonica
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2002
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tom 49
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nr 1
We here report the influence of the cell cycle abrogator UCN-01 on RKO human co­lon carcinoma cells differing in p53 status following exposure to two DNA damaging agents, the topoisomerase inhibitors etoposide and camptothecin. Cells were treated with the two drugs at the IC90 concentration for 24 h followed by post-incubation in drug-free medium. RKO cells expressing wild-type, functional p53 arrested the cell cy­cle progression in both the Gj and G2 phases of the cell cycle whereas the RKO/E6 cells, which lack functional p53, only arrested in the G2 phase. Growth-arrested cells did not resume proliferation even after prolonged incubation in drug-free medium (up to 96 h). To evaluate the importance of the cell cycle arrest on cellular survival, a non-toxic dose of UCN-01 (100 nM) was added to the growth-arrested cells. The addi­tion of UCN-01 was accompanied by mitotic entry as revealed by the appearance of condensed chromatin and the MPM-2 phosphoepitope, which is characteristic for mi- totic cells. G2 exit and mitotic transit was accompanied by a rapid activation of caspase-3 and apoptotic cell death. The influence of UCN-01 on the long-term cytotoxic effects of the two drugs was also determined. Unexpectedly, abrogation of the G2 arrest had no influence on the overall cytotoxicity of either drug. In contrast, addition of UCN-01 to cisplatin-treated RKO and RKO/E6 cells greatly increased the cytotoxic effects of the alkylating agent. These results strongly suggest that even prolonged cell cycle arrest in the G2 phase of the cell cycle is not necessarily coupled to efficient DNA repair and enhanced cellular survival as generally believed.
3
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Induction of ornithine decarboxylase in normal and protein kinase C - depleted human colon carcinoma cells

86%
Ostrowski J., Szczepiorkowski Z., Trzeciak L., Rochowska M., Skurzak H., Butruk E.
Journal of Physiology and Pharmacology
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1992
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tom 43
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nr 4
To examine the role of protein kinase С (PKC) in induction of human colon adenocarcinoma cell line, DETA/W, by polypeptide growth- promoting factors, ornithine decarboxylase activity (ODC) and DNA synthesis were determined in cells depleted of PKC. PKC depletion was achieved by prolonged cultivation (more than 30 passages) with 10⁻⁶ M phorbol 12-myristate 13-acelate. Lack of PKC in studied cells was proved by measurements of PKC activity and immunoreactivity. Although ODC activities and DNA syntheses in PKC-depleted cells were decreased by about 40-50% compared to normal DETA/W cells, the percentage increase of these mitogen-responsive reactions was quantitatively similar in both cell sublines. These results raise the possibility that not all of the biological responses to growth factors are connected with the activation of calcium-dependent PKC.
4

Antimetastatic potentials of 8-aryl-2,6,7,8-tetrahydroimidazo [2,1-C] [1,2,4]triazine-3,4-diones

72%
Sztanke K., Pasternak K., Sztanke M., Kandefer-Szerszen M.
Journal of Elementology
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2009
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tom 14
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nr 3 Suppl.
81-82
5

The effect of wortmannin and promoting phorbol ester [TPA] on migration of ovary carcinoma cells

72%
Miloszewska J., Szaniawska B., Kowalczyk D., Janik P.
Cellular and Molecular Biology Letters
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1999
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tom 04
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nr 2
The purpose of the present study was to determine the role of PI 3 kinase in tumor cell migration. The migration of ovary carcinoma cells (OVP10) was strongly inhibited by wortmannin to the same extent as by TPA treatment. The strongest additive inhibitory effect was noted after cell treatment with wortmannin and TPA together. Western blotting studies showed activation / partial down regulation of PKC after TPA treatment and decreased amount of the enzyme following wortmannin exposure. Altogether, it looks like wortmannin inhibits migration of studied cells.
6

Basal cell subpopulation as putative human prostate carcinoma stem cells

72%
Kuzmanov A., Hayrabedyan S., Karaivanov M., Todorova K.
Folia Histochemica et Cytobiologica
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2007
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tom 45
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nr 2
7

SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells

72%
Majka M., Drukala J., Lesko E., Wysoczynski M., Jenson A. B., Ratajczak M. Z.
Folia Histochemica et Cytobiologica
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2006
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tom 44
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nr 3
8

Effect of exogenous tumor necrosis factor alpha, interleukin 6 and interferons on vesicular stomatitis virus replication in human placenta and amniotic membrane organ cultures

72%
Paradowska E., Blach-Olszewska Z., Gierlinska M., Woyton J.
Archivum Immunologiae et Therapiae Experimentalis
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1996
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tom 44
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nr 1
9

DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells

58%
Wiktorska M., Papiewska-Pajak I., Okruszek A., Sacewicz-Hofman I., Niewiarowska J.
Acta Biochimica Polonica
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2010
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tom 57
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nr 3
 In this study we evaluated efficiency of DNAzymes to modulate motility of cancer cells, an important factor in the progression and metastasis of cancers. For this purpose we targeted β1 integrins that are predominant adhesive receptors in various carcinoma cell lines (CX1.1, HT29, LOVO, LS180, PC-3). To evaluate invasiveness of cancer cells, we used a transwell migration assay that allowed analyzing chemotactic migration of colon carcinoma cell lines across an ECM-coated membrane. Their adhesive properties were also characterized by the analysis of adhesion to fibronectin, laminin and collagen. In addition, the expression of major integrin subunits, selected intact β1 integrins, and other adhesive receptors (ICAM, E-selectin, uPAR) was analyzed by flow cytometry. Inhibition of β1 integrin expression by DNAzyme to β1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro. These data show that DNAzymes to β1 integrin subunit can be used to inhibit invasiveness of carcinoma cells.
10
Content available remote

Position of STAT-1alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line: role of polyphenolic compounds

58%
Pajak B., Gajkowska B., Orzechowski A.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 3
119-141
“Immune escape” is a crucial instrument used by carcinoma cells to overcome numerous strategies of immune system to delete transformed cells. Cellular factors that make cancer cells immune to defence mechanisms are incompletely understood while some remain ambiguous. Up to date evidence points to some proteins and/or signaling molecules that might be a basis for unusual behavior of cancer cells. In particular STAT kinases are currently in the main focuse of attention since they were both shown to accelerate and/or to inhibit apoptosis. In our studies we observed that human colorectal COLO 205 cancer cells were resistant to TNF-alpha- or cycloheximide-induced cytotoxicity. However, when TNF-alpha (10 ng/ml) has been given along with cycloheximide (5 µg/ml, CHX) COLO 205 cells died extensively from apoptosis. Apparently, cycloheximide sensitized cells to TNF-alpha-induced programmed cell death. To investigate the role of STAT-1alpha in CHX-mediated TNF-alpha-induced COLO 205 cell death certain polyphenolic compounds were studied if they modulate STAT-1alpha phosphorylation status and STAT-1alpha-protein interaction at the level of TNF-alpha signalosome in the 6th, 12th, and 24th hour of experiment. Neither of phenolic compound, namely PI-3K inhibitor (LY294002, 20 µM) nor MEK inhibitor (PD98059, 50 µM), nor flavonol quercetin or kaempferol (10, 100 µM) in contrast to apigenin (20 µM) influenced COLO 205 cell viability during individual or combined treatment with TNF-alpha and CHX. We conclude, that some antiapoptotic proteins were involved but not STAT-1alpha kinase to resist TNF-alpha-dependent cell death promoting activity. Summing up, except apigenin, the above-mentioned polyphenolic componds were unable to modulate survival signal in COLO 205 cells initially believed to be suppressed by STAT-1alpha.
11

Targeting liposomes and lipoplexes to cells in the liver

58%
Scherphof G. L., Koning G., Bartsch M., Yan X., Kamps J.
Cellular and Molecular Biology Letters
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2002
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tom 07
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nr 2
12

The effect of steroids and their complexes with cyclodextrins on secretory activity of cultured thyroid medullary carcinoma cells

58%
Grzeszkowiak J., Seidel J., Zabel M.
Folia Histochemica et Cytobiologica. Supplement
|
1996
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tom 34
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nr 1
13

Immunohistochemical study in breast carcinoma. S100-protein positive cells and neuroendocrine differentiation

58%
Zoltowska A., Moszkowska G., Zamorska B., Roszkiewicz A.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
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tom 44
|
nr 4
14

Cell shape and cell adhesion

51%
Korohoda W., Wojciak B.
Biophysics of Membrane Transport
|
1992
|
tom 11
|
nr 1
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Search for mouse gene related to GA733 human tumor antigen gene

51%
Zielewicz J., Skrzypczak M., Wojcierowski J.
Journal of Applied Genetics
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1995
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tom 36
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nr 3
Human antigen GA733-1, defined as 40 kDa cell glycoprotein, is one of the antigens associated with gastrointestinal carcinomas. Its studies may contribute to the tumor etiology and therapy effects in animal model.
16

Epidermal growth factor signalling in rat pancreatic acinar cells

51%
Stryjek-Kaminska D.
Journal of Physiology and Pharmacology. Supplement
|
1998
|
tom 49
|
nr 1
17

Novel model of stimulation of periosteal osteogenesis and of perichondreal chondrogenesis by oncogenic virus Mu-MSV and its application in bone research

44%
Wlodarski K. H., Wlodarski P. K., Luczak M., Galus K.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1994
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tom 42
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nr 3
18

Accumulation of epidermal growth factor [EGF] in melanoma cell line B16

44%
Jagodzinski P. P., Trzeciak W. H.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1992
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tom 40
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nr 3
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