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Response of specific immunoglobulin E to foods in children with atopic dermatitis

100%

Passeti S. R. M., Fonseca F. L. A., Wandalsen N. F.

Archivum Immunologiae et Therapiae Experimentalis

2014

tom 62

nr 5

Food allergy insights: a changing landscape

67%

De Martinis M., Sirufo M. M., Viscido A., Ginaldi L.

Archivum Immunologiae et Therapiae Experimentalis

2020

tom 68

nr 2

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Atopic eczema: genetics or environment?

59%

Wuthrich B., Cozzio A., Roll A., Senti G., Kundig T., Schmid-Grendelmeier P.

Annals of Agricultural and Environmental Medicine

2007

tom 14

nr 2

Atopic eczema (AE) is a multifactorial skin disease caused by a variety of factors such as genetic conditions, alterated skin structure, immunologic deviations and environmental factors, among others. There are two main subtypes of AE, i.e. the IgE-associated (“atopic eczema”) and the non-IgE-associated type (“nonatopic eczema”) with different prognosis concerning the development of respiratory diseases (“atopy march”). Recently, it was demonstrated that Filaggrin (= fi lament-aggregating protein, FL) is a major gene for atopic eczema. Filaggrin binds to and aggregates the keratin cytoskeleton in the epidermis. Homozygous FLG mutation leads to complete loss of fi laggrin expression in skin. Half or more of children with moderate to severe AE carry FLG mutations. Moreover, fi laggrin loss-of-function mutations predispose to phenotypes involved in the atopy march. The altered skin structure and a defi ciency in antimicrobial peptides favour colonization with Staphylococcus aureus and yeasts (Malassezia sp.). Sensitization to the yeast occurs almost exclusively in AE patients. S. aureus enterotoxins with superantigenic activity stimulate activation of T cells and macrophages. So far, AE skin lesions are orchestrated by the local tissue expression of proinfl ammatory cytokines and chemokines with activation of T lymphocytes, dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils which lead to the skin infl ammatory responses. From the therapeutic point of view, besides emollients and local corticosteroids, topic immunomodulatory drugs (tacrolimus and pimecrolimus) have substantially improved the treatment of AE.

Ograniczanie wyników

2 Archivum Immunologiae et Therapiae Experimentalis

1 Annals of Agricultural and Environmental Medicine

1 Cozzio A.

1 De Martinis M.

1 Fonseca F. L. A.

1 Ginaldi L.

1 Kundig T.

1 Passeti S. R. M.

1 Roll A.

1 Schmid-Grendelmeier P.

1 Senti G.

1 Sirufo M. M.

1 Viscido A.

1 Wandalsen N. F.

1 Wuthrich B.

1 2020

1 2014

1 2007

Wyniki wyszukiwania

Response of specific immunoglobulin E to foods in children with atopic dermatitis

Food allergy insights: a changing landscape

Atopic eczema: genetics or environment?