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1

Phytosulfokines exert antinociceptive effect in rats

100%
Plech A., Konopinska D., Rykaczewska-Czerwinska M., Bahyrycz A.
Pestycydy
|
2004
|
nr 3-4
2

Study on the role of NO radical in the mechanism of antinociceptive effect of proctolin in rats

75%
Plech A., Konopinska D., Kuczer M., Jakrzewska H., Rykaczewska-Czerwinska M., Maksym B., Radecki Z.
Pestycydy
|
2006
|
nr 1-2
15-19
3

Nitric oxide mediates antinociceptive effect of leucopyrokinin active analog [2-8]-leucopyrokinin [[2-8]-LPK]

75%
Rykaczewska-Czerwinska M., Konopinska D., Plech A.
Pestycydy
|
2005
|
nr 4
65-70
4

Antinociceptive effect of insect hexapeptide, insect trypsin modulating oostatic factor [Neb-TMOF] in rats

75%
Plech A., Kuczer M., Szewczyk A., Konopinska D.
Pestycydy
|
2005
|
nr 1-2
5-13
5

Peripheral antinociceptive effect of biphalin in a mouse model of cancer pain

63%
Lesniak A., Bochynska-Czyz M., Sacharczuk M., Lipkowski A. W.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr 1
It is generally accepted that classical opioids exert their antinociceptive effect mainly when binding to opioid receptors located in the central nervous system. However, a growing body of evidence points to the relevance of peripheral opioid receptors in periphery pathology, including cancer. A cancer is very often the cause of pain resulting from peripheral metastasis. The peripheral component of antinociception induced by a dimeric enkephalin analog – biphalin showing limited blood-brainbarrier permeability may prove important in cancer pain therapy. An additional advantage of biphalin is a possibility to treat pain symptoms with reduction of side-effects – a result of the central action of some other opioid analgesics, e.g. morphine. We examined the peripheral and central analgesic effect of biphalin in a murine skin cancer pain model developed by an intraplantar inoculation of B16T0 melanoma cells. Animals developed robust thermal hypersensitivity in the tumor-bearing paw compared to PBS-injected individuals. Biphalin produced stronger analgesia in the tumor-bearing paw than morphine upon a comparable central effect. Our results suggest that biphalin analgesia manifested in the periphery is linked to a less effective transport through the bloodbrain barrier. We speculate that the centrally effective dose of biphalin equipotent to morphine simultaneously produces analgesia via peripheral opioid receptors. Thus, biphalin may become useful in cancer pain treatment as an alternative drug executing a local as well as a central analgesic response with limited undesirable side-effects.
6
Content available remote

Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study

63%
Huang C. W., Hung T. Y., Liao Y. K., Hsu M. C., Wu S. N.
Journal of Physiology and Pharmacology
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2013
|
tom 64
|
nr 3
7

Central opioid receptors mediate antinociceptive effect in rats of insect hexapeptide - trypsin modulating oostatic factor [Neb-TMOF] and of its synthetic analogs

63%
Rykaczewska-Czerwinska M., Wrobel M., Kuczer M., Konopinska D., Plech A.
Pestycydy
|
2006
|
nr 1-2
21-27
8
Content available remote

The analgesic and anticonvulsant effects of piperine in mice

51%
Bukhari I. A., Alhumayyd M. S., Mahesar A. L., Gilani A. H.
Journal of Physiology and Pharmacology
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2013
|
tom 64
|
nr 6
9
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Antinociceptive effect of MAS MT in rats

51%
Rykaczewska-Czerwinska M., Radosz A., Szymanowska-Dziubasik K., Konopinska D., Plech A.
Pestycydy
|
2008
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nr 3-4
139-146
MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.
10

Influence of insect neuropeptide proctolin analogue [Cha[4-OMe]2]-proctolin on central nervous system in rats

51%
Plech A., Rykaczewska M., Stronczak W., Brus R., Sobotka R., Konopinska D.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1992
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tom 40
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nr 1
11

Behavioural effects of insect neuropeptide leucopyrokinin [LPK] in rats

51%
Rykaczewska-Czerwinska M.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
2002
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tom 50
|
nr 2
12

Behavioural effects of [2-8]-leucopyrokinin [[2-8]-LPK], an active, synthetic analogue of insect neuropeptide leucopyrokinin [LPK] in rats

51%
Rykaczewska-Czerwinska M., Konopinska D., Plech A.
Pestycydy
|
2004
|
nr 3-4
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