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1

Biochemical targets affected by subacute doses of new pesticide mixtures tested on albino rats

100%
Shalaby S. E. M., El-Mageed A. E. M. A.
Journal of Plant Protection Research
|
2010
|
tom 50
|
nr 4
Few studies have characterize the toxicological effects of exposure to pesticide mixtures. For this reason, the present study aimed to estimate the median lethal doses (LD50) of some new pesticide mixtures; chlorosan, feroban, cygron, engeo and kingbo on albino rats. The in vivo effect of these compounds on some biochemical targets were also investigated. The estimated median lethal doses (LD50) of chlorosan, feroban, engeo and cygron were 140.8, 264.0, 281.5 and 352.0 mg/kg body weight (b.w.), respectively. The estimated median lethal dose was more than 160.0 mg/kg b.w. in the case of kingbo. The symptoms of the affected animals included salivation, bleeding, activity increase and the chlorosan treated rats closed their eyes. Some animals died after doses of chlorosan, feroban and engeo administered at different intervals. The results showed a significant increase in the activities of plasma transaminases [Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT)] and glutathione S-transferase (GST). It was found that the tested pesticides significantly inhibited acetylcholinesterase (AChE) activity 1 h after the last dose. Also, there was a significant increase in creatinine and urea levels. The obtained data concluded that chlorosan was the most effective against albino rats followed by feroban and engeo, while kingbo was the least effective. By the end of the experiment, the enzyme activities and kidney functions of animals treated with chlorosan, feroban and engeo did not return to normal.
2

The presence of acetylcholinesterase-positive nerve fibres in the deep pineal gland and the pineal stalk but not in the superficial part of adult albino rats

100%
Swiatkiewicz G.
Folia Biologica
|
2000
|
tom 48
|
nr 3-4
3

Absence of acetylcholinesterase-positive nerve structure in the superficial part of the pineal gland of adult albino rat

100%
Swiatkiewicz G.
Folia Biologica
|
1996
|
tom 44
|
nr 3-4
4

Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

84%
Omar A. I., Kamar S. S.
Folia Histochemica et Cytobiologica
|
2021
|
tom 59
|
nr 2
5

Toxicological affects of essential oils from eucalyptus Eucalyptus globules and clove Eugenia caryophyllus on albino rats

84%
Shalaby S., Magd El-Din M., Abo-Donia S., Mettwally M., Attia Z.
Polish Journal of Environmental Studies
|
2011
|
tom 20
|
nr 2
The present work was planned to determine the median lethal doses (LD₅₀) and to evaluate the haematological and biochemical changes, and histopathological effects of the essential oils from eucalyptus Eucalyptus globules L. and clove Eugenia caryophyllus on liver and kidney of albino rats. The LD₅₀ was 2,334.4 and 3,597.5 mg/kg b.w. of eucalyptus and clove oils, respectively. Obtained data revealed that 1/10 LD₅₀ of both tested oils resulted in a significant increase in WBC counts and produced a significant decrease in haemoglobin concentration and platelets count at 5th and 10th doses, as well as RBC counts (-17.1 and -9.4% below normal level) at 10th dose. The activities of serum GOT and GPT enzymes were a significant increase at 5th and 10th doses in treated rats by both tested oils. While two essential oils had mild effect on kidney function, these oils produced a significant increase in creatinine and urea concentration at the 10th dose. Histopathological studies on liver and kidney revealed that both essential oils caused relatively moderate pathological changes in the liver as congestion of the blood vessels in the portal area associated with inflammatory infiltration. Also, two tested oils induced desquamation of the epithelial cells of the renal tubules.
6

Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea

84%
Hassan Z. A., Zauszkiewicz-Pawlak A., Abdelrahman S. A., Algaidi S., Desouky M., Shalaby S. M.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 3
7

Effects of acute and chronic triazolam treatments on brain GABA levels in albino rats

84%
Aburawi S. M., Elhuwuegi A. S., Ahmed S. S., Saad S. F., Attia A. S.
Acta Neurobiologiae Experimentalis
|
2000
|
tom 60
|
nr 4
The present study investigated the effects of acute and chronic intraperitoneal administration of Triazolam on g-aminobutyric acid (GABA) levels in different brain areas of albino rats. Three experiments were conducted. In the first, five groups of rats were acutely treated with different doses of Triazolam (0.25 mg/kg-4.0 mg/kg). In the second experiment, rats were treated chronically with a single daily dose of Triazolam (started with 0.25 mg/kg and increased by time to 1.0 mg/kg) for 5 weeks, simulating clinical use. In the third, rats were treated chronically with three daily doses of Triazolam (started with 0.25 mg/kg and increased by time to 0.5 mg/kg) for 20 days, representing a form of drug abuse. Brain levels of GABA and plasma levels of Triazolam were measured using high performance liquid chromatography (HPLC). The acute Triazolam administration produced an increase in GABA levels in all brain areas studied. The chronic administration of single daily dose of Triazolam produced normal GABA levels in all brain areas except brain stem where the levels were significantly decreased; this indicates the development of tolerance to Triazolam action on increasing GABA content. The chronic administration of three daily doses of Triazolam produced a decrease in GABA levels in all brain regions studied. In conclusion, chronic single daily dose treatment (representing normal use) produces tolerance to Triazolam effects on brain GABA levels, while chronic three daily doses administration (akin to drug abuse) causes a fall in GABA levels.
8

Effect of nonionizing fields on biological membranes

84%
Ali F. M., Ghanam M., Elrefaei G. F., Elgebaly R., Abou-El-Ela K., Hussein A., Surour D., Mohamed I.
Biophysics of Membrane Transport. Supplement
|
1994
|
tom 12
9
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Effect of thyroxin induction on enzymatic and biochemical levels in albino rats

67%
Hanchinalmath J. V., Shivasharanappa K., Roopa T. S., Saisundeep Y.
International Letters of Natural Sciences
|
2014
|
tom 08
|
nr 2
The albino Wistar rats were used to investigate the effect of thyroxine administration on the activity of citric acid, α-Amylase, creatine phosphokinase (CPK), creatinine, cholesterol and triglycerides level in blood serum and citric acid in liver and kidney. Two groups of rats were taken for the experiment. One group was injected subcutaneously with 200 μl of thyroxine/50 g of body weight, the other group served as control. The animals were vivisected with anesthesia after intervals of 24, 48, 72 and 96 hours α-Amylase and CPK levels in blood; citric acid level in liver and kidney of control and thyroxine treated rats. The results showed that the α-Amylase activity remained unaltered (100 g/h/l) throughout the experiment. However, citric acid level found to be 460 mg in the liver and 415 mg in kidney of control rats. The values slightly increased to 480 and 680 mg in respective tissues of thyroxine treated animals for 24 hr. The values decreased in 48 and 72 hours of treatment. Further the values found to be increased after 96 hours of treatment. Although the thyroxine treatment altered citric acid, Creatinine, Cholesterol, Triglycerides and CPK levels in the tissues, the serum α-Amylase was not influenced by the thyroxine. The study suggests that the thyroxine acts as a regulator all the above parameters in the cellular level.
10

Projection of visuotopically organized afferents to the dorsal thalamus in the opossum, Monodelphis domestica

67%
Turlejski K., Djavadian R. L., Saunders N. R.
Acta Neurobiologiae Experimentalis
|
1994
|
tom 54
|
nr 4
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