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Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F₁ mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectiveness of larvae.
The authors used Albendazole in a single dose of 400 mg in 40 students from Africa and Asia, infected with Ascaris lumbricoides, Trichocephalrus trichiurus and Ancylostomatidae. At the third day after the treatment no parasite eggs have been found in 25 of 30 cases of ancylostomatidosis (83.3%), 16 of 23 cases of trichocephalosis (69.6%) and in all treated cases of ascaridosis (100%). It has been also found that the tolerance for the medicine is good in most patients. Only in two patients (2%) there appeared short time and not very strong pains in the upper part of the abdomen and headaches. An important property of Albendazole is its ability to destroy nematode eggs which is essential for the prophylaxis and nature conservation.
The aim of the study was to evaluate the efficiency of various methods of antiparasitic prophylaxis using a conventional chemical agent and a formulation containing plant essential oils. The animal material consisted of 139 mother ewes of two synthetic prolific meat lines: BCP and SCP. During the entire experiment the animals were kept in an indoor management system with uniform environmental conditions. The experiment included ewes lambing within the period of 12 consecutive days. Using the results of coproscopic tests performed after lambing, the animals were randomised into three study groups: Group A – wormed with an albendazolecontaining preparation (50 sheep); Group L – receiving a lick with antiparasitic essential oils (48 sheep); and Group C – control group, not wormed (41 sheep). Two antiparasitic agents were used. A chemical agent containing albendazole. The procedure was performed on day 35 after lambing, and the dose administered was 5 mg of the active substance per kg bw, which corresponded to 0.5 ml orally, per 10 kg bw. A natural worming agent was administered in the form of licks containing essential oils of Thymus vulgaris, Allium sativum, Artemisia absinthium, Dryopteris filixmax, Tanacetum vulgare, Cucurbita pepo, Chenopodium ambrosioide, Inula helenium, Peumus boldo and Corallina rubens. The licks were made available to animals on day 21 after lambing. The experiment involved parasitologic tests aimed at the determination of estimated intensity (based on OPG and EPG data) and prevalence of invasions of gastrointestinal parasites in mother ewes. The study material was faeces collected from the rectum on the following dates: after lambing, and on day 28, 42, 56, 70 and 100 of a lamb’s life. The observations proved that the formulation based on natural plant ingredients had a beneficial influence on the reduction of prevalence of Eimeria and Capillaria. It was also shown that the albendazole-containing chemical preparation is highly efficient in reducing the prevalence of Trichostrongylidae, Nematodirus, as well as Capillaria.
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