Wyniki wyszukiwania

1

The use of acute phase proteins as markers of diseases in dairy herds

100%

Tothova C., Nagy O., Seidel H., Kovac G.

Prace i Materiały Zootechniczne

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2009

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tom 67

Acute phase proteins became an interesting point of investigations also in veterinary medicine. In the last several years, there has been considerable progress in studies on the understanding of their functions, and influences on the organism. The benefit to laboratory and clinical diagnosis of diseases has been established also. In general, the acute phase response is a result of proinflammatory cytokines being secreted into the circulation from sites of infection or inflammatory lesions. Among the many pathophysiological responses of an animal to stimulation, there is an increased production and secretion of some plasma proteins from the liver, which are known in generally as acute phase proteins. Despite the uniform nature of the acute phase response, there are numerous differences in the production of acute phase proteins between various animal species. In bovine medicine, the principle acute phase protein to be used is haptoglobin in conjunction with serum amyloid A, which are elevated in some important bovine inflammatory diseases such as laminitis, metritis, or mastitis, as well as in some physiological conditions. Investigations over the last decade have shown that the quantification of their concentrations in plasma or serum can provide valuable diagnostic information in the detection, prognosis and monitoring of disease. Moreover, monitoring the blood concentrations of acute phase proteins can provide additional information on the progression of the inflammatory reaction. The circulating concentration of these proteins is related to the severity of the underlying condition and thus quantification of their concentrations provides a ready means of evaluating the presence and extent of the disease processes causing the response.

2

Evaluation of acute phase protein levels and some cytokine levels in pneumonic calves

100%

Akgul O., Kozat S., Ozkan C., Kaya A., Akgul Y.

Medycyna Weterynaryjna

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2019

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tom 75

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nr 03

This study was carried out to determine the levels of various cytokines (TNF-α, IL-6, IL-8) and acute phase proteins (haptoglobin, C-reactive protein, serum amyloid A, alpha 1-acid glycoprotein, lactoferrin, and fibrinogen) in pneumonic calves, to reveal changes in these parameters depending on etiologic factors (bacterial, viral, bacterial + viral) in calf pneumonia, and to determine whether these parameters could be used for diagnosis and prognosis of the disease. The study was carried out on a total of 50 calves consisting of 10 healthy and 40 pneumonic animals aged 1 to 6 months. The pneumonic calves were classified into three groups: bacterial, viral and mixed (bacterial + viral). It was found that the levels of IL-6, IL-8, CRP, and TNF-α were statistically higher in the pneumonic calves than in the control group animals. It was found that the increase in levels of Serum IL-6, IL-8, and CRP were highest in the mixed infection group (bacterial + viral) and lowest in the virally infected group. Similarly, serum levels of Hp, CRP, SAA, α-1-AGP, and LF were found to be more statistically significant (P <0.01) in the infected calves than in the control group animals, but changes in fibrinogen levels were not statistically significant. Although the TP and ALB levels in the pneumonic calves were numerically higher than the same parameters in the control group, this was not statistically significant (P > 0.05). As a result, this study showed that serum levels of cytokines (IL-6, IL-8, TNF-α) and serum concentrations of acute-phase proteins (Hp, CRP, SAA, α-1-AGP, and LF) are significantly higher in the pneumonic calves than in the control group calves. Furthermore, the assessment of cytokine and acute phase protein levels can play an important role in the early diagnosis of calf pneumonia. This early diagnosis can help prevent deaths caused by pneumonia, which is the leading cause of major losses, and can also be helpful in the early treatment of pneumonia in the veterinary clinical field.

3

Acute phase response in calves as a result of experimental challenge with Mycoplasma bovis

100%

Dudek K., Bednarek D., Szymanska-Czerwinska M.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 4

The aim of the study was to investigate the influence of Mycoplasma bovis challenge in calves on the alteration of acute- phase response (APR). The study was performed on twelve calves aged 4-8 weeks. The animals were divided into two equal groups: experimental and control. Calves in the experimental group were intratracheally challenged with pathogenic strain of Mycoplasma bovis, whereas controls received sterile physiological saline as placebo. The blood samples were collected before (1st d) and after the mycoplasma challenge (3, 5, 7 and 9th d). The following parameters were assayed in serum: acute phase proteins (APPs), i.e. haptoglobin (Hp) and amyloid A (SAA), and eicosanoids such as prostaglandin E₂ (PGE₂), prostaglandin F₂ₐ (PGF₂ₐ), leukotrien B4 (LTB₄), and tromboxan B₂ (TXB₂). In calves of experimental group, a significant increase in concentrations of Hp and SAA was observed when compared with the controls. A decrease in both APPs to the initial values, i.e. before the challenge, was noted on the 9th d of experiment. On the other hand, the inoculation of Mycoplasma bovis caused a significant increase of the examined eicosanoids, which maintained elevated during the whole study. The stimulation of synthesis of APPs and eicosanoids in response to the challenge with Mycoplasma bovis probably indicates the effective activation of APR under these conditions.

4

Assessment of acute phase response in turkeys experimentally infected with Escherichia coli or haemorrhagic enteritis virus

100%

Mazur-Gonkowska B., Koncicki A., Krasnodebska-Depta A.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 1

5

Selected cytokines and acute phase proteins in heifers during the ovarian cycle course and in different pregnancy periods

100%

Krakowski L., Zdzisinska B.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 1

The studies were done on 30 heifers with synchronized oestrus. IFN-γ was found in sera of 4 heifers in luteal phase and in 1 heifer in follicular phase. Moreover, an increased level of serum haptoglobulin (Hp) and serum amyloid component (SAA) was found in 8 heifers in follicular phase. The presence of IFN-γ a proinflammatory cytokine may point to an active inflammation, whereas an increased level of Hp and SAA in oestrus could be connected with an approaching ovulation. It was also found that in pregnant heifers with a detected IFN-γ and TNF-α and an increased level of Hp and SAA retention of placenta and post parturient metritis was diagnosed.

6

Serum concentrations of some acute phase proteins in cats with anaemia

84%

Tuna G. E., Dinler C., Ekren Asici G. S., Ulutas B.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 09

Serum concentrations of acute phase proteins can provide valuable diagnostic information in the detection and monitoring of disease. The available information on the acute phase response in cats with anaemia is limited. The aim of this study was to retrospectively evaluate serum concentrations of haptoglobin, serum amyloid A, α1 acid glycoprotein and their clinical importance in cats with anaemia. Thirty-four anaemic cats and ten healthy cats were enrolled this study. After individual diagnoses had been established, the cats were divided into three groups (healthy group, haemolytic group and non-haemolytic group). Serum acute phase protein concentrations were analysed using specific commercially available test kits in an ELISA reader device. Serum amyloid A and serum α1 acid glycoprotein concentrations were significantly higher in the anaemic groups compared with the healthy group. Haptoglobin concentrations were significantly higher in cats from the non-haemolytic anaemia group than they were in healthy animals and those from the haemolytic anaemia group. Although serum haptoglobin concentrations were lower than in the healthy group, there was no significant difference between the haemolytic anaemia group and the healthy group. The results of this study suggest that serum amyloid A and α1 acid glycoprotein could be useful in the diagnosis and determination of inflammation in cats with anaemia. Serum haptoglobin depletion may be used for diagnosis of haemolysis in cats with haemolytic anaemia. In addition, this study has contributed to the limited data available on acute phase protein concentrations in cats with anaemia.

7

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

84%

Erdogan H., Akin I., Ural K., Ulutas P. A.

Medycyna Weterynaryjna

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2019

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tom 75

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nr 07

The purpose of this study was to evaluate the effects of ketoprofen (KTP), flunixin meglumine (FLM), and meloxicam (MLX) administration on acute-phase proteins after dehorning in Holstein heifers. A total of 21 Holstein heifers were enrolled into three groups of equal size (n=7) and administered ketoprofen, flunixin meglumine, or meloxicam, at doses of 2.2 mg/kg, 1.1 mg/kg, and 1 mg/kg body weight, respectively. Serum amyloid A, haptoglobin, and ceruloplasmin levels were determined before the administration of the three drugs (0 hrs) and at 6, 12, 24, 48, and 96 hours post-administration. The mean values (±SD) obtained revealed no significant alteration in APP levels at 0 hrs in any of the three groups. Time-dependent alterations, however, were significant in all groups. Group-time interactions were significant (P < 0.001) for ceruloplasmin concentrations, whereas results for serum amyloid A and haptoglobin levels were deemed non-significant. Inter-group interaction revealed no significant findings regarding serum amyloid A and ceruloplasmin levels, but haptoglobin levels showed a significant difference between the KTP and FLM groups at 48 hrs. It may therefore be reasonably suggested that KTP, FLM, and MLX could all be administered to effect slight changes in acute phase proteins.

8

Human inter-alpha-inhibitor family in acute inflammation: simultaneous synthesis of positive and negative acute phase proteins

84%

Daveau M., Rouet P., Scotte M., Faye L., Hiron M., Lebreton J. P., Salier J. P.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

9

The association of 5' haptoglobin genes -flanking sequences with nuclear matrix proteins during the acute phase response

84%

Poznanovic G., Grujic V., Ivanovic-Matic S., Sevaljevic L.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

10

Cytokine, cytokine receptors and glucorticoid network controlling N-glycosylation of acute phase proteins in vitro

84%

Mackiewicz A.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

11

Fetuin - a new acute phase protein in the adult and in the fetus

84%

Dziegielewska K. M., Andersen N. A., Lovell D., Nicol S. C., Muller-Esterl W., Saunders N. R.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

12

Poszukiwanie czynnikow rokowniczych losow zakazenia HBV - na przykladzie wybranych bialek ostrej fazy

67%

Paszkiewicz J.

Acta Biologica et Medica

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1993

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tom 20

90-99

13

Acute phase proteins in serum and milk and their relation to milk somatic cell count in dairy cows

67%

Kovac G., Tothova C., Popelkova M., Petrovic V.

Prace i Materiały Zootechniczne

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2009

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tom 67

The aim of this study was to compare the concentrations of two acute phase proteins, haptoglobin (Hp) and serum amyloid A (SAA), in serum and milk of Holstein-Friesian dairy cows grouped according to somatic cell count (SCC) thresholds (<100,000; <400,000; >400,000 cells/ml) in composite milk samples. The SCC was assessed quantitatively by FOSSOMATIC 90 analyser, serum and milk Hp and SAA concentrations were determined using commercial ELISA kits (Tridelta Development, Ltd., Wicklow, Ireland). We have found significantly higher Hp and SAA concentrations in the group with SCC >400,000 cells/ml compared to groups with lower SCC thresholds in composite milk samples. In contrast, significant differences were not recorded between the groups in serum Hp and SAA concentrations. The concentrations of Hp in serum and milk were found to be correlated (r = 0.69, P = 0.0003), whereas there was a lower correlation trend in the case of serum versus milk concentrations of SAA (r = 0.43, P = 0.0478). High significant correlations were observed either between milk haptoglobin values and SCC or milk serum amyloid A concentrations and SCC (r = 0.83, r = 0.81, P<0.0001; respectively). An increase in SCC in cows suffereing from mastitis has been accompained by strong elevation of the milk Hp and SAA, significantly correlated with serum Hp (r = 0.64, P = 0.0014) and poorly correlated with SAA values determined in serum (r = 0.43, P = 0.0478). According to the results obtained in this study we can conclude that measurements of the acute phase proteins, haptoglobin and serum amyloid A predominantly in milk, may be useful tool in diagnosing mastitis and may be a useful marker of milk quality.

14

Porcine acute phase protein response to experimental infection with Bordetella bronchiseptica

67%

Pomorska-Mol M., Urbaniak K., Markowska-Daniel I.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

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nr 3

The response of five positive acute phase proteins (APP) was evaluated in pigs after infection with Bordetella bronchiseptica (Bbr). Twelve piglets from a herd with high health status were used. Six of them were infected intranasally with Bbr (3.4 x 10⁸ cfu). The standard bacteriological methods and PCR were used for detection of Bbr in nasal swabs, lungs, and bronchoalveolar fluids. Serum APP concentrations were measured using commercial tests. Various kinetics of response was identified within the APP tested. C-reactive protein and serum amyloid A was characterised as a ven fast, transient responder, while haptoglobin as a fast and very prolonged responder. Pig major acute phase protein was characterised as a fast, protracted responder. Alfa-l-acid-glycoprotein did not respond significantly after inoculation. No correlations were found between levels of APP in serum and changes in the turbinates. On the basis of the investigation we cannot state that evaluation of APP concentrations in serum may provide useful information about severity of atrophic rhinitis. However, the concentration of most investigated APP increased after inoculation. Thus, APP measurement could be the primary screening test prior to specific disease diagnosis. "APP-high" animals may be chosen next for pathogen-specific diagnostics. Moreover, monitoring of serum APP concentrations may be useful for selecting clinically healthy pigs before integration into an uninfected herd.

15

Dynamics of variations of acute phase proteins in pigs fed Bioimmuno and/or immunised with Respisure One vaccine against mycoplasmal pneumonia

67%

Procajlo Z., Szweda W., Siwicki A., Platt-Samoraj A., Mikulska-Skupien E.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

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nr 1

The purpose of the study was to determine the influence of the Bioimmuno administration in feed and/or immunisation with the 'Respisure' One vaccine against mycoplasmal pneumonia of swine on the development of non-specific immune response expressed by the level of acute phase proteins (APP). The study was performed on 28 piglets at the age of 4 weeks, divided into four equal groups. The biopreparations were administered according to the following pattern: group I - Bioimmuno (1 kg/50 kg of feedstuff) for 48 h and then vaccination with Respisure One (2 ml/animal i.m.), group II - Bioimmuno ( 1 kg/50 kg of feedstuff) for 48 h, group III - Respisure One (2 ml/animal i.m.), and group C (control) - PBS (2 ml/animal i.m.). Serum concentration of APP: C- reactive protein, haptoglobin, and ceruloplasmin were determined on days 0, 3, 7, 14, and 21 after immunomodulation and/or immunisation. The statistically significantly lower (P<0.05) levels of all determined APP in the experimental groups in comparison with the control group were demonstrated. This proves the protective value of the biopreparations applied in specific patterns, through their beneficial influence on the decrease in consequences of the respiratory system infections in pigs.

16

Serum acute phase proteins in neuroblastoma children at diagnosis and during the clinical treatment. A preliminary report

67%

Lipinska L., Laskowska-KLita T., Izbicki T.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

17

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Plasma C3D levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings

67%

Hoffmann H. J., Iversen M., Brandslund I., Sigsgaard T., Omland O., Oxvig C., Holmskov U., Bjermer L., Jensenius J. C., Dahl R.

Annals of Agricultural and Environmental Medicine

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2003

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tom 10

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nr 1

Work in swine confinement buildings leads to an inflammatory response and may be associated with increased levels of acute phase proteins. We compared the inflammatory response of a control group of young former farm workers with age-matched former farm workers who had previously developed the lower airway symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings, and because of these symptoms had stopped work. Both groups were subjected to an experimental exposure in a swine confinement building for 3 hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated with respirable dust, significantly so for individual cases and for the whole cohort. Plasma C3, fibrinogen and alpha1-acid glycoprotein peaked 1 and 6 h after exposure start, mannan-binding lectin, C-reactive protein and alpha1-antitrypsin peaked after 2 h. Surfactant protein D (SP-D) and alpha2-macroglobulin were downregulated. In lavage, only SP-D, alpha2-macroglobulin and fibronectin were detected. FEV1, FVC, TLC and FEV25-75 did not vary during exposure. There was complement activation in response to respiratory dust, more so amongst cases than in the control group. Acute exposure, with work related levels of organic dust containing endotoxin, leads to a weak systemic inflammatory response.

18

Nuclear factor-kappaB: a key regulator in health and disease of lungs

59%

Batra S., Balamayooran G., Sahoo M. K.

Archivum Immunologiae et Therapiae Experimentalis

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2011

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tom 59

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nr 5

19

Extrahepatic synthesis of acute phase proteins and their functions

59%

Aldred A. R., Southwell B., Schreiber G.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

Ograniczanie wyników

The use of acute phase proteins as markers of diseases in dairy herds

Evaluation of acute phase protein levels and some cytokine levels in pneumonic calves

Acute phase response in calves as a result of experimental challenge with Mycoplasma bovis

Assessment of acute phase response in turkeys experimentally infected with Escherichia coli or haemorrhagic enteritis virus

Selected cytokines and acute phase proteins in heifers during the ovarian cycle course and in different pregnancy periods

Serum concentrations of some acute phase proteins in cats with anaemia

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

Human inter-alpha-inhibitor family in acute inflammation: simultaneous synthesis of positive and negative acute phase proteins

The association of 5' haptoglobin genes -flanking sequences with nuclear matrix proteins during the acute phase response

Cytokine, cytokine receptors and glucorticoid network controlling N-glycosylation of acute phase proteins in vitro

Fetuin - a new acute phase protein in the adult and in the fetus

Poszukiwanie czynnikow rokowniczych losow zakazenia HBV - na przykladzie wybranych bialek ostrej fazy

Acute phase proteins in serum and milk and their relation to milk somatic cell count in dairy cows

Porcine acute phase protein response to experimental infection with Bordetella bronchiseptica

Dynamics of variations of acute phase proteins in pigs fed Bioimmuno and/or immunised with Respisure One vaccine against mycoplasmal pneumonia

Serum acute phase proteins in neuroblastoma children at diagnosis and during the clinical treatment. A preliminary report

Plasma C3D levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings

Nuclear factor-kappaB: a key regulator in health and disease of lungs

Extrahepatic synthesis of acute phase proteins and their functions