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1
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The nasal airway evaluation in morbid obesity

100%
Namyslowski G., Mrowka-Kata K., Scierski W., Wylezol M., Pardela M.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
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nr 6
67-75
The aim of the present study was to evaluate objectively the nasal patency in the obese patients. A total of 18 morbidly obese patients were recruited for the study. All of them were surgically treated because of morbid obesity using Bilo-Pancreatic Diversion (BPD) or Laparoscopic Gastric Banding (LGB) methods. The patients were free of nasal abnormalities, such as septum deviation, polyps, nasal concha hypertrophy and paranasal sinus diseases. This group comprised 10 men and 8 women aged from 17 to 54. The mean Body Mass Index (BMI) was 51.6 kg/m2, ranged from 34.7 to 61.8 kg/m2. In all of the patients the nasal patency was examined by active anterior rhinomanometry according International Standardization Rhinomanometric Committee using air pressure 75, 100 and 150 dPa. The results were compared to the healthy control group. The correlation between BMI and nasal airflow pressure was also examined. We found that inspiration values for 75, 100 and 150 dPa as well as the expiration values for 100 and 150 dPa in standard method and expiration values for 100 and 150 dPa in Broms method using anterior rhinomanometry in morbidly obese patients were statistically significant higher in comparison with the healthy controls. No statistical significant correlation between BMI of obese patients and the airflow pressure values was found. We conclude that in the morbide obesity the nasal patency is reduced as compared to the healthy controls.
2
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The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in hemorrhagic shock in rats

86%
Sowa P., Adamczyk-Sowa M., Zwirska-Korczala K., Namyslowski G., Misiolek M., Pierzchala K.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 2
3
Content available remote

Sleep study in patients with overweight and obesity

86%
Namyslowski G., Scierski W., Mrowka-Kata K., Kawecka I., Kawecki D., Czecior E.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
|
nr 6
59-65
Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by repetitive collapse of the pharyngeal airway during sleep, which leads to oxygen desaturation, sleep fragmentation and daytime somnolence. Obesity is one of the most important risk factor for the development of OSAS. The exact mechanisms responsible for the relationship between obesity and OSAS are still unclear. The fat deposits in the pharynx region as well as the reduction in the lung volume have been considered as factors that might be responsible for the increase of the upper airway collapsibility. The aim of our study was to evaluate the correlation between the Body Mass Index (BMI) and sleep study parameters in overweight and obese patients suffering from breathing disturbances during sleep. We studied a group of 106 consecutive obese or overweight patients with a primary complaint of snoring or other breathing disturbances during sleep. In all cases, BMI and sleep studies (PolyMESAM) were examined. We evaluated relationship between the BMI and sleep study parameters such as Respiratory Disturbance Index (RDI), Apnea Index (AI), Desaturation Index (DI) and Average of Lowest Saturation (LSAT). The results showed the lack of significant statistical correlations between BMI and all the sleep parameters studied in the overweight patients and the statistical positive correlation between the BMI and RDI in the obese cases. We conclude that BMI determination may be considered as a simple, yet important predictor, of the OSAS in the group of obese patients.
4
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Sleep apnea syndrome and snoring in patients with hypothyroidism with relation to overweight

72%
Misiolek M., Marek B., Namyslowski G., Scierski W., Zwirska-Korczala K., Kazmierczak-Zagorska Z., Kajdaniuk D., Misiolek H.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 1
77-85
5
Content available remote

Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism

59%
Zwirska-Korczala K., Adamczyk-Sowa M., Sowa P., Pilc K., Suchanek R., Pierzchala K., Namyslowski G., Misiolek M., Sadowski K., Kato I., Kuwahara A., Zabielski R.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
|
nr 1
53-64
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