Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 5

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

The expression of myogenic regulatory factors and muscle growth factors in the masticatory muscles of dystrophin-deficient (MDX) mice

100%
Spassov A., Gredes T., Gedrange T., Lucke S., Pavlovic D., Kunert-Keil C.
Cellular and Molecular Biology Letters
|
2011
|
tom 16
|
nr 2
The activities of myogenic regulatory factors (MRF) and muscle growth factors increase in muscle that is undergoing regeneration, and may correspond to some specific changes. Little is known about the role of MRFs in masticatory muscles in mdx mice (the model of Duchenne muscular dystrophy) and particularly about their mRNA expression during the process of muscle regeneration. Using Taqman RT-PCR, we examined the mRNA expression of the MRFs myogenin and MyoD1 (myogenic differentiation 1), and of the muscle growth factors myostatin, IGF1 (insulin-like growth factor) and MGF (mechanogrowth factor) in the masseter, temporal and tongue masticatory muscles of mdx mice (n = 6 to 10 per group). The myogenin mRNA expression in the mdx masseter and temporal muscle was found to have increased (P < 0.05), whereas the myostatin mRNA expressions in the mdx masseter (P < 0.005) and tongue (P < 0.05) were found to have diminished compared to those for the controls. The IGF and MGF mRNA amounts in the mdx mice remained unchanged. Inside the mdx animal group, gender-related differences in the mRNA expressions were also found. A higher mRNA expression of myogenin and MyoD1 in the mdx massterer and temporal muscles was found in females in comparison to males, and the level of myostatin was higher in the masseter and tongue muscle (P < 0.001 for all comparisons). Similar gender-related differences were also found within the control groups. This study reveals the intermuscular differences in the mRNA expression pattern of myogenin and myostatin in mdx mice. The existence of these differences implies that dystrophinopathy affects the skeletal muscles differentially. The finding of gender-related differences in the mRNA expression of the examined factors may indicate the importance of hormonal influences on muscle regeneration.
2
Content available remote

Differential expression of genes involved in the calcium homeostasis in masticatory muscles of mdx mice

100%
Kunert-Keil C., Gredes T., Lucke S., Brotzenhart U., Dominiak M., Gedrange T.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 2
3

Talin, vinculin and nestin expression in orofacial muscles of dystrophin deficient mdx mice

100%
Spassov A., Gredes T., Pavlovic D., Gedrange T., Lehmann C., Lucke S., Kunert-Keil C.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 2
4

Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice

84%
Kunert-Keil C., Gredes T., Lucke S., Morgenstern S., Mielczarek A., Sporniak-Tutak K., Gedrange T., Spassov A.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 2
5
Content available remote

Morphological evaluation of bone defect regeneration after treatment with two different forms of bone substitution materials on the basis of bonitmatrix

84%
Kunert-Keil C., Gedrange T., Mai R., Spassov A., Lucke S., Klinke T., Kalukin J., Loster B. W., Gredes T.
Journal of Physiology and Pharmacology. Supplement
|
2009
|
tom 60
|
nr 8
57-60
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.