CPPG is a highly potent group III metabotropic glutamate receptor (mGluR4/6/7/8) antagonist with selective affi nity to mGluR4. The aim of the present study was to determine the effects of CPPG on spatial memory in the water maze, and on the activity of MMP-2 and MMP9 metalloproteases in the hippocampus of rats without and after hypoxia. Short-term hypoxia (2% O2 and 98% N2) enhances excitatory synaptic transmission and impairs spatial acquisition in the water maze. We observed that CPPG prolonged only escape latency during the fi rst day of training in water maze in group without hypoxia, while it did not infl uence escape latency, distance travelled and swim speed during training of rats after hypoxia. It did not change previously acquired escape response during free-swim trial in either group of rats. Hypoxia signifi cantly increased the activity of the proform of MMP-9 in the hippocampus. Gel zymography showed elevations of MMP-2 and MMP-9 activity in the hippocampus of rats without or after hypoxia when CPPG was administered. Concluding, CPPG has no effects on defi cits of behavioural processes induced by hypoxia in the water maze. Enhanced activity of MMP-2 and MMP9 in the hippocampus induced by CPPG does not correspond to the infl uence on acquisition in the water maze. The reconfi guration of extracellular matrix by MMP-2 and MMP-9 in hippocampus is new central effect of CPPG. Support: grant No 3-10614L from the State Committee for Scientifi c Research, Warszawa, Poland.
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