The association of insulin resistance and dementia was observed by several authors. The activity of paraoxonase1 (PON1), the enzyme playing a protective role against oxidative stress, was decreased in demented patients. The aim of this study was to investigate relationship of PON1 Q192R polymorphism and insulin resistance. From demented patients (59 with probable AD, 24 with VaD and 38 with MD) and 51 controls DNA was isolated and Q and R isoforms were identified basing on Humbert et al.method (1993) with minor modifications. In the same subjects the following determinations were performed: serum fasting glucose, glucose 2 hours after 75g glucose load and fasting insulin using DRG ELISA kits. HOMA-IR index was calculated.. In the patients with dementia 47.9% of QQ , 43% of QR and 9.1% of RR genotypes were identified and in the controls respectively 54.9, 35.3 and 9.9 ones . Statistically significant associations of the R allele carriers with insulin level and with HOMA-IR index were stated. Borderline significant association with glucose after glucose load level (impaired glucose tolerance-IGT) were observed. The results show the asssociation of Q192R PON1 polymorphism with insulin resistance. However due to the small sample size the results should be considered as preliminary.
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