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Neurobiologia optymizmu

100%
Rygula R.
Wszechświat
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2014
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tom 115
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nr 01-03
2

Effects of acute administration of L-DOPA on cognitive judgment bias of rats in the ambiguous-cue interpretation paradigm

68%
Kregiel J., Golebiowska J., Rygula R.
Acta Neurobiologiae Experimentalis
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2014
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tom 74
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nr 3
The monoamine serotonin (5-HT) has long been implicated in the modulation of affective and cognitive processing and has been consistently linked to depression, anxiety and negative mood. In the present study, we investigated the effects of acute administration of selective serotonin reuptake inhibitor – escitalopram (S- enantiomer of citalopram) on the valence of cognitive judgment bias of rats in the ambiguous-cue interpretation (ACI) paradigm. In this paradigm the rats are trained to press one lever in response to one tone to receive a reward and to press another lever in answer to a different tone to avoid punishment. Cognitive judgment bias is than tested by measuring the pattern of animals‘ responses to a tone of intermediate frequency (ambiguous-cue). After initial behavioural training, the animals received single injections of 3 different doses of escitalopram and were subsequently tested with the ACI paradigm. The drug was administered using fully randomised Latin square design. Escitalopram (0.5, 1 and 2 mg/kg) had no significant effects on the interpretation of the ambiguous cue by rats. The results are discussed in terms of pharmacological action of escitalopram. Supported by the National Science Centre (Research grant: Sonata bis dec-2012/07/E/NZ4/00196) and the statutory funds of the Institute of Pharmacology PAS.
3

Effects of acute administration of escitalopram on cognitive judgment bias of rats in the ambiguous-cue interpretation paradigm

68%
Golebiowska J., Kregiel J., Rygula R.
Acta Neurobiologiae Experimentalis
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2014
|
tom 74
|
nr 3
Recent research has shown that pharmacological enhancement of dopaminergic function by acute administration of L-DOPA increases an optimism bias in humans. In the present study, we investigated whether L-DOPA have similar effects in rats. To accomplish this goal, the animals were trained in the ambiguouscue interpretation (ACI) paradigm. In this paradigm the rats must press one lever in response to one tone to receive a reward and to press another lever in answer to a different tone to avoid punishment. Cognitive judgment bias is than tested by measuring the pattern of animals‘ responses to a tone of intermediate frequency (ambiguous-cue). After initial behavioral training, the rats received single injections of L-DOPA and were subsequently tested with the ACI paradigm. The drug was administered in 3 doses using a fully randomized Latin square design. Control animals received injections of physiological saline. L-DOPA at all tested doses (2, 4 and 8 mg/kg, co-administered with benserasidine 12.5 mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue. The results are discussed in relation to human studies. Supported by the National Science Centre (Research grant: Sonata bis dec-2012/07/E/NZ4/00196) and the statutory funds of the Institute of Pharmacology PAS.
4

Effects of lithium and valproate on cognitive judgment bias of rats in the ambiguous-cue interpretation paradigm

68%
Rygula R., Golebiowska J., Kregiel J.
Acta Neurobiologiae Experimentalis
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2014
|
tom 74
|
nr 3
Mania is a debilitating psychiatric condition and a cardinal feature of Bipolar Disorder. One of the critical features of mania is over-optimistic judgment bias leading to high-risk behaviors. As both; lithium and valproate are well-established treatments for mania in humans, in the present study, using recently developed ambiguous-cue interpretation test (ACI) we assessed the effects of treatment with these two drugs on cognitive judgment bias in rats. To accomplish this goal, in two separate experiments, previously trained animals were treated with 3 different doses of either valproate (100, 200 and 400 mg/kg) or lithium chloride (10, 50 and 100 mg/kg) and were subsequently tested with the ACI paradigm. The drugs were administered using fully randomized Latin square designs. Control animals received physiological saline injections. We report that neither valproate nor lithium chloride had significant effects on ambiguous-cue interpretation in rats. Supported by Polish Ministry of Science and Higher Education (Research grant: Iuventus Plus IP2011047271 to RR) and the statutory funds of the Institute of Pharmacology PAS.
5

Cognitive judgment bias in the cocaine-induced model of mania in rats

68%
Kubik J., Golebiowska J., Kregiel J., Rygula R.
Acta Neurobiologiae Experimentalis
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2014
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tom 74
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nr 3
Chronic psychostimulant administration is a frequently used, however unspecific, model of mania in rodents. In our study, we investigated whether chronic administration of cocaine may produce in rats, also more specific, cognitive symptoms of mania, such as the hyperoptimistic cognitive judgment bias. To accomplish this goal, after initial behavioral training, 2 groups of rats were subjected either to 2 weeks of chronic cocaine treatment or physiological saline injections. Before and after the treatment the animals were tested with ambiguous-cue interpretation paradigm. We report that chronic cocaine administration does not produce optimistic judgment bias in rats. Supported by the National Science Centre (Research grant: Sonata bis dec-2012/07/E/NZ4/00196) and the statutory funds of the Institute of Pharmacology PAS.
6

Investigation of the microbiota in rats classified as pessimistic or optimistic in the ambiguous-cue interpretation test

43%
Wojcik K., Kubera M., Witana K., Curzytek K., Gil M., Trojan E., Leja J., Rygula R., Potempa J.
Postępy Mikrobiologii. Suplement
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2017
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tom 56
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nr 3
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