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Oral squamous cell carcinoma (OSCC) - molecular, viral and bacterial concepts

100%

Polz-Gruszka D., Macielag P., Foltyn S., Polz-Dacewicz M.

Journal of Pre-Clinical and Clinical Research

2014

tom 08

nr 2

Head and neck cancers constitute the sixth most common malignant tumours worldwide, and are one of the majors problems of global public health. In the oral cavity there are several types of oral cancers, but around 90% are squamous cell carcinoma. Many different risk factors play a role in the etiology of head and neck cancer. The aim of this study is presentation from the aspect of molecular, viral and bacterial infection. Knowledge about all factors which influence the development of these malignances is essential for diagnostics and successful treatment.

Prevalence of Polyoma BK virus ( BKPyV) , Epstein-Barr virus (EBV) and Human Papilloma virus (HPV) in oropharyngeal cancer

100%

Polz-Gruszka D., Morshed K., Jarzynski A., Polz-Dancewicz M.

Polish Journal of Microbiology

2015

tom 64

nr 4

The aim of this study was to analyze the prevalence of BK virus, Human Papillomavirus and Epstein-Barr virus in oropharyngeal cancer, and to test our hypothesis that BKV/HPV/EBV co-infection plays a role in oropharyngeal squamous cell carcinoma. The correlation between viral infection, OSCC, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from 62 patients from paraffin tissue blocks. Males (90.3%) with, smoking (83.9%) and alcohol abuse (67.7%) problems prevailed in the studied group. G2 histological type was recognized in 80.6% cases. T4 (77.4%) and N2 (56.5%) traits occurred in the majority of patients. No cases of metastasis were observed (M0 100%). HPV – 24.2%, EBV – 27.4% and BKV 17.7% were detected in the studied samples. We observed co-infection EBV/BKV in 8% of cases, HPV/BKV in 4.8%, and HPV/EBV in 9% cases. Only in two cases co-infection of all three viruses was found.

Ograniczanie wyników

1 Journal of Pre-Clinical and Clinical Research

1 Polish Journal of Microbiology

2 Polz-Gruszka D.

1 Foltyn S.

1 Jarzynski A.

1 Macielag P.

1 Morshed K.

1 Polz-Dacewicz M.

1 Polz-Dancewicz M.

1 2015

1 2014

Wyniki wyszukiwania

Oral squamous cell carcinoma (OSCC) - molecular, viral and bacterial concepts

Prevalence of Polyoma BK virus ( BKPyV) , Epstein-Barr virus (EBV) and Human Papilloma virus (HPV) in oropharyngeal cancer