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Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs

100%

Nam A., Kim S. M., Jeong J. W., Song K. H., Koo T. S., Seo K. W.

Polish Journal of Veterinary Sciences

2017

tom 20

nr 3

This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m². The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.

Ograniczanie wyników

1 Polish Journal of Veterinary Sciences

1 Jeong J. W.

1 Kim S. M.

1 Koo T. S.

1 Nam A.

1 Seo K. W.

1 Song K. H.

1 2017

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Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs