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Odbudowa protetyczna wrodzonego braku zawiazkow zebow przedtrzonowych psa na implantach systemu Alpha Bio. Opis przypadku

100%

Niedzielska I., Skowronek J., Niedzielski Z.

Medycyna Weterynaryjna

2004

tom 60

nr 09

946-947

Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

64%

Niedzielska I., Niedzielski Z., Tkacz M., Orawczyk T., Ziaja K., Starzewski J., Mazurek U., Markowski J.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 1

65-71

The aim of this study was to identify differences in Toll-like receptor (TLR) expression patterns in normal and diseased tissues of patients with polyps and colorectal cancer. Eight patients were included in the study group (aged 38 to 72 years). Sixteen HG-U133A oligonucleotide microarrays were analysed including four of colonic polyps, four of adenocarcinoma with different degree of histological differentiation (2 poorly and 2 highly differentiated), and eight of macroscopically normal tissue. The levels of selected TLR mRNA transcripts were analysed. An analysis of all per cent variability values with regard to malignancy stage increasing from polyp to stages I to III adenocarcinoma, and normal colon mucosa shows a statistically significant relationship for TLR2 (increasing) and TLR3 (decreasing). In polyps, copy numbers of TLR3, TLR4 and TLR5 mRNA were the highest and TLR7 mRNA the lowest. In normal colon mucosa of polyposis patients the highest mRNA copy numbers were observed for TLR3, and the lowest for TLR7. TLR3 may serve as a marker of colon tissue metaplasia and may indicate the tendency of normal tissue to form polyps transforming to colorectal cancer.

Gene expression profile analysis in laryngeal cancer by high-density oligonucleotide microanalysis

51%

Markowski J., Oczko-Wojciechowska M., Gierek T., Jarzab M., Paluch J., Kowalska M., Wygoda Z., Pfeifer A., Tyszkiewicz T., Jarzab B., Niedzielska I., Borgiel-Marek H.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 1

57-63

The assessment of gene expression profile in laryngeal cancer shall allow to implement molecular biology methods in diagnostics, as well as in prognosis of the course of disease. Thus, it may influence the choice of the most optimal decisions in regards to the method of treatment, extent of surgical procedure, or the necessity of adding post-operative radiotherapy. The aim of the project was to analyse the gene expression profile of laryngeal cancer using oligonucleotide microarrays, aiming to derive novel molecular markers for that carcinoma. The study comprised a group of 14 patients (12 males and 2 females) with squamous cell laryngeal carcinoma, diagnosed and surgically treated between 2005 – 2007 in the ENT Department of the Silesian Medical University in Katowice, Poland. RNA was isolated from frozen tissue fragments. To assess gene expression profile, high density oligonucleotide microarrays (Affymetrix U 133 Plus 2.0) were applied, with over 54 thousand probesets for over 47 thousand transcripts. Four genes, previously not assesed in diagnostic context in laryngeal carcinoma, seemed to be valuable markers of that neoplasm. These are: metalloproteinase ADAM12, cycline-dependent kinase 2 - CDK2, kinesine 14 - KIF14, suppressor 1 of checkpoint - CHES1.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology. Supplement

1 Medycyna Weterynaryjna

3 Niedzielska I.

2 Markowski J.

2 Niedzielski Z.

1 Borgiel-Marek H.

1 Gierek T.

1 Jarzab B.

1 Jarzab M.

1 Kowalska M.

1 Mazurek U.

1 Oczko-Wojciechowska M.

1 Orawczyk T.

1 Paluch J.

1 Pfeifer A.

1 Skowronek J.

1 Starzewski J.

1 Tkacz M.

1 Tyszkiewicz T.

1 Wygoda Z.

1 Ziaja K.

2 2009

1 2004

Wyniki wyszukiwania

Odbudowa protetyczna wrodzonego braku zawiazkow zebow przedtrzonowych psa na implantach systemu Alpha Bio. Opis przypadku

Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

Gene expression profile analysis in laryngeal cancer by high-density oligonucleotide microanalysis