Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Plasma profile of cimicoxib in sheep after oral administration at two different rates

100%

Di Salvo A., Giorgi M., Lee H. K., Vercelli C., Rueca F., Trabalza Marinucci M., della Rocca G.

Polish Journal of Veterinary Sciences

2017

tom 20

nr 3

Sheep are often subjected to painful procedures and thus they need to be treated with analgesics. Nevertheless, knowledges about pharmacokinetic features of these drugs in this species are poor. The aim of this study was to evaluate plasma behaviour of cimicoxib in sheep after a single oral administration at two different dose rates (4 and 6 mg/kg). Maximum plasma concentrations of cimicoxib were equal to 273.78 (median value; range 189.00-567.32) and 565.01 (range 308.27-822.59) ng/mL after treatment with 4 and 6 mg/kg, respectively. The time of maximum concentration (Tmax) was achieved between 4 and 10 hours following treatment at the lower dose, and between 6 and 10 hours after the administration of the higher dose, with one sheep achieving the concentration peak at 0.75 hours. The slow absorption and the great individual variability in plasma concentration, probably due to ruminal effects, suggest that cimicoxib is not suitable for oral treatment in sheep.

Ograniczanie wyników

1 Polish Journal of Veterinary Sciences

1 Di Salvo A.

1 Giorgi M.

1 Lee H. K.

1 Rueca F.

1 Trabalza Marinucci M.

1 Vercelli C.

1 della Rocca G.

1 2017

Wyniki wyszukiwania

Plasma profile of cimicoxib in sheep after oral administration at two different rates