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1

Role of pericardial effusion in dogs with and without cardiac neoplaesia

100%
Bakirel U., Ulgen S.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 04
428-431
In this research, LV systolic functions of the 14 mature dogs with idiopathic pericardial effusion (IHPE) and cardiac neoplaesia (CN) were examined. The dogs were between 1-16 years old, generally large breed and male. Signs of cardiomegaly were observed in the chest radiography and low amplitude QRS complexes in electrocardiograms. Pericardial effusion, cardiac masses and paradoxical motion were detected by 2D echocardiography. Left ventricle (LV) systolic functions were detected with M mode echocardiographic examinations. A statistical significance (p<0.001) was found between echo-free pericardial Space (EPS) and fractional shortening (FS%), ejection fraction (EF%), velocity of circumferential fiber shortening (VcF), in the dogs with IHPE. A distinction was also found between EPS and EF in the dogs with CN (p < 0.001). FS, EF and VcF were significantly decreased in the dogs with IHPE in contrast to the dogs with CN. It was detected that the systolic function of the left ventricle could be considerably disturbed by the excessive volume of the pericardial effusion, even if no cardiac tamponade occurred.
2

Effect of combined treatment with carprofen and enalapril on ductus construction in dogs with patent ductus arteriosus

80%
Bakirel U., Gunes S., Bakirel T.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 11
1324-1327
The purpose of this study was to evaluate the effect of a combined treatment with carprofen and enalapril on ductus construction in the medical treatment of Golden retriever dogs with PDA which are unable to undergo surgical treatment and have delayed diagnosis. PDA was diagnosed by using Doppler, echocardiography, electrocardiography, X-ray, and blood analysis in 5 golden retrievers. Carprofen (2 mg/kg) and enalapril (0.5 mg/kg) were administered daily for 12 months and the dogs were controlled at 3 monthly intervals. Ductal construction was detected as 11% (p = ns) at the 3rd month, 24% (p < 0.05) at the 6th month, and 31% (p < 0.01) at the 9th month and 38% (p < 0.001) at the 1st year. An increase in the diameter of the main pulmonary artery was revealed after the 9th month (p < 0.05). No significant alteration was determined in the diameter of aorta, fractional shortening (FS %) and ejection fractioning (EF %) during the treatment. The results of the study indicated that the effect of a combined treatment of carprofen and enalapril is revealed after a long time period. Although a statistically significant decrease occurred in the diameter of the ductus, no complete closure in the ductus occurred. It was also detected that the severity of clinical signs in the dogs with PDA type-2, which had rendered them unacceptable for operation, was decreased by this medication.
3

Subacute echocardiographic effects of ACE inhibitors in the dogs with severe mitral regurgitation

80%
Bakirel U., Gunes S., Meral Y., Bakirel T.
Bulletin of the Veterinary Institute in Puławy
|
2008
|
tom 52
|
nr 3
The effects of the angiotensin converting enzyme inhibitors benazepril (B), enalapril (E), and ramipril (R) on the function, geometry, and dimensions of the left ventricle (LV) in the dogs with naturally acquired severe mitral regurgitation (MR) were evaluated by echocardiography. Thirty-two dogs, aged 8-16 years and weighing 10-12 kg, with fractional shortening (FS) >50% were included into the study. Benazepril (0.5mg/kg/d), enalapril (0.5mg/kg/d), and ramipril (0.5mg/kg/d) were administered orally to B, E, and R groups, respectively. Furosemide (2mg/kg/d) was administered orally for conventional heart failure therapy. Physical, radiographic, electrocardiographic, and echocardiographic examinations were performed before treatment and on day 7 after the treatment. A decrease in the left ventricle end diastolic diameter (LVEDd) in groups E and R and in end diastolic volume (EDV) in group E was considerable during the subacute period (P<0.05). The stroke volume (SV) significantly decreased in groups E and R (P<0.01), whereas group B dogs had a mild decrease (P<0.05). FS and ejection fraction (EF) that were higher before treatment decreased significantly in all groups after the treatment (P<0.001). Differences in SV, FS, and EF were not statistically significant between groups. It was detected that LV was remodelled as a result of the effects of enalapril and ramipril on LVEDd and also EDV was decreased by enalapril. Furthermore, it was observed that these ACE inhibitors were effective on geometry, dimensions, and functions on LV of the dogs with severe MR, and enalapril was found to be the most effective agent, followed by ramipril and benazepril.
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