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1

Role of perirhinal cortex in the short-term auditory recognition memory in rat

100%
Jakubowska-Dogru E., Wesierska M., Elibol B., Guven S.
Acta Neurobiologiae Experimentalis
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2007
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tom 67
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nr 3
2

Effect of binge-like ethanol administration on macromolecule profiles in hippocampus of young adult wistar rats as assessed by FT-IR spectroscopy

100%
Severcan F., Elibol B., Jakubowska-Dugru E.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 3
Despite of widespread abuse and the presence of vast data about ethanol’s adverse effects on behavior, brain morphology and physiology, molecular mechanism underlying deteriorating effects of chronic ethanol intoxication on the nervous system still remain elusive. The aim of the present study is revisiting the potential effects of adult alcohol insult and/or withdrawal on the protein, nucleic acids, and lipid profi les in the rat hippocampus by using Fourier Transform Infrared (FTIR) spectroscopy. It is a rapid, sensitive and non-disturbing technique which gives information about different functional groups belonging to biomolecules, simultaneously [Garip et al. (2007) Appl Spectrosc]. In the current study the rats were intragastrically administered ethanol at a dose increasing from 4.5 g to12 g/kg for 15 days and then the mean blood alcohol concentration was measured as 605.67 ± 36 mg/dl. FTIR results revealed an increase in the total content of proteins, lipids, as well as amino, fatty, and nucleic acids. Moreover, an increase in lipid disordering and a decrease in membrane fl uidity were obtained. Chronic ethanol intoxication was also found to cause an increase in random coil and aggregated β sheet content indicating structural changes in proteins, such as denaturation. Signifi cant variations in DNA and RNA conformation were observed. These molecular changes are discussed in terms of their potential effects on the neural function.
3

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus

88%
Elibol B., Beker M., Sahbaz C. D., Kilic U., Jakubowska-Dogru E.
Acta Neurobiologiae Experimentalis
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2019
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tom 79
|
nr 2
It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol – and maternal stress-induced morphological and functional deficits correlates with compensatory changes in the expression/activation of the brain proteins involved in inflammation, cell survival and apoptosis. In this project, we investigated the hippocampus which belongs to the brain regions most susceptible to the adverse effects of prenatal ethanol exposure. Pregnant rat dams were administered ethanol (A) or isocaloric glucose solution (IC) by a gastric intubation during gestational days 7-20. The pure control group received ad libitum laboratory chow and water with no other treatment. The hippocampi of fetal-ethanol and control pups were examined at the postnatal day (PD)1, PD10, PD30 and PD60. Moderate fetal-ethanol exposure and prenatal intubation stress caused a significant increase in molecular factors relating to inflammation (iNOS) and cell survival/apoptosis pathways (PTEN, GSK-3 and ERK) at birth, with a rapid compensation from these developmental deficits upon removal of alcohol at PD10. Indeed, an increase in ERK1/2 and JNK1/2 activation at PD30 was observed with ethanol consumption. It indicates that the recovery process in A and IC brains started soon after the birth upon the ethanol and stressor withdrawal and continued until the adulthood.
4

Study of the potential effects of fetal exposure to diclofenac sodium on brain morphology and behavior in young wistar rats

64%
Jakubowska-Dogru E., Elibol B., Arikan B., Sezer M., Kaya Z., Tufanh O., Ragbetli M., Kaplan S.
Acta Neurobiologiae Experimentalis
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2009
|
tom 69
|
nr 3
Diclofenac sodium (DS) acts as a potent cyclooxygenase inhibititor, reducing arachidonic acid release and prostaglandins formation. It is commonly used as a non-steroid anti-infl ammatory drug and the potential adverse effects of its administration during pregnancy are of medical and public concern. In the present study, the DS in a dose of 1 mg/kg/day was subcutaneously injected to the pregnant Wistar rats throughout 5–20 gestational days. One group of 4-week old pups was sacrifi ced and the counts of principal neurons in cerebellum and hippocampus were done using stereological methods. Another group of pups was subjected to a battery of behavioral tasks. A signifi cant decrease in the total number of Purkinje cells but not CA pyramidal neurons was observed in the drug-treated juvenile pups. No substantial between-group differences were found in most of the applied behavioral tasks including plus maze anxiety test, and learning/memory tasks such as 12-arm radial maze and the Morris water maze, the latter run both under allo- and idiothetic stimulus conditions. Only in the Open Field test, fetal DS male but not female pups showed slower rate of habituation compared to controls. The obtained results indicated that the moderate doses of DS administered between 5–20 gestation days in rats equivalent of the second half of the 1st and the whole 2nd trimester in human) resulted in some neuronal losses which, however, had no adverse behavioral impact.
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