The aim of the study was the analysis of the repolarization period in Great Dane dogs. Fifty-eight clinically healthy Great Danes (30 males, 28 females) between 1 and 9 years old (3.2 ± 1.8 years old on average) were included in the study. A resting ECG with the use of limb (I, II, III, aVR, aVL, aVF) and precordial leads (V1, V2, V4) in the right lateral position was performed in each dog. Fifty-eight ECG curves were analyzed. The following parameters were assessed: rhythm, heart rate (HR), duration of the P wave, PQ duration interval, duration of QRS, and the R-wave amplitude. The repolarization period was assessed using 7 parameters: duration of the QT interval, adjusted duration of the QT interval (acc. to Fridericia formula), the T-wave amplitude, total repolarization time, duration of early and late (TpTe) repolarizations, and the Te/QT ratio. Statistical analysis was carried out by the U Mann-Whitney test and Spearman rank correlation, and a significance level of p < 0.05 was adopted. All parameters used for the standard assessment of the ECG curve were within reference values for giant dog breeds. A higher average duration of QRS (66 ms ± 4.9) was observed, but in no dog did it exceed 70 ms. No significant sex differences in the QT (203 ms ± 19.1 vs 204.5 ms ± 15.7) or QTcF (259.4 ms ± 14.2 vs 263 ms ± 13.7) intervals were observed. The T-wave amplitude was positive in 31 (53.44%), negative in 14 (24.14%), and biphase in 13 (22.42%) of the ECG recordings. A correlation of TpTe and TpTe/QT with the sex of the dogs was observed. Statistically significant differences in the values of TpTe and TpTe/QT were observed between males and females. Sex-related norms for these parameters were calculated (average ± 2 SD). They were TpTe 18-42 ms, TpTe/QT 0.1-0.2 for females and TpTe 16-54 ms, TpTe/QT 0.1-0.25 for males. No correlation of TpTe and TpTe/QT with age was observed.
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