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Background: A tilt table test is a useful, non-invasive technique that has been used for the last few decades to detect autonomic failure. The response to tilting may vary physiologically between sexes. Aim of the study: To assess the gender-specific changes in cardiovascular response to a tilt test in healthy subjects. Material and methods: This experimental study was conducted on 90 healthy males and females aged 18–60 years, from 2019 to 2020. Forty-five male subjects and 45 female subjects were included. Using a motorized tilt table, a tilt table test was performed at 60 degrees for 10 minutes. An automatic sphygmomanometer was used to measure blood pressure (BP), and heart rate (HR) and a pulse oximeter was used for the measurement of peripheral capillary oxygen saturation (SpO₂). An independent sample t test, a multiple regression analysis and a chi squared test were conducted for statistical analyses. Results: A significantly greater drop in systolic blood pressure (SBP) was observed in females, compared to males after tilting. In 5.5% of the subjects, orthostatic intolerance occurred, but there were no significant age or gender- specific differences in subjects with orthostatic intolerance. Conclusions: This study concluded that in response to tilting, cardiovascular response was less pronounced in females.
Determining the influence of a sublethal concentration of the organophosphate pesticide profenofos on the proximate composition of muscle in Catla catla, Labeo rohita, and Cirrhinus mrigala was the aim of this study. Three sublethal concentrations of profenofos were given to the fish in three replicates for eight weeks. Moisture content exhibited a rapid increase in C. catla, L. rohita, and C. mrigala, with an increase in the dose of profenofos. Decreases in protein, fat, and carbohydrate contents were recorded against different sublethal doses of profenofos in C. catla, L. rohita, and C. mrigala compared to control fish. Ash contents exhibited no proper order of an increase or decrease in these fish species against the exposure of different doses of profenofos. It has been concluded that the maximum allowable toxicant concentration (MATC) endpoints for protein, fat, ash, and carbohydrate were more sensitive and may be successfully used as a new biomarker for monitoring early changes induced by pesticides. The findings of this study may be helpful for monitoring and regulatory agencies to develop a strategy against these important pollutants.
Exposure to metals remains an important public health concern. The present study is a comprehensive field study to determine the concentrations of Cu, Zn, Ni, Cd, Co, Pb and Cr in water samples and in the livers of deceased freshwater turtles collected from pre-determined sampling sites of the Ravi and Chenab rivers. In total, 35 deceased freshwater turtles were collected from the sampling sites, and liver samples were collected and immediately stored at -20ºC prior to analysis. Heavy metals concentrations of Cu, Zn and Cd (0.073, 0.169 and 0.0042 mg/L⁻¹) in water samples were collected from the Ravi and (0.084, 0.145 and 0.0041 mg/L⁻¹) from the Chenab. Concentrations of Ni, Co, Pb and Cr were significantly lower (0.045, 0.018, 0.06 and 0.121 mg/L⁻¹) in the Ravi while (0.045, 0.018, 0.064 and 0.121 mg/L⁻¹) in the Chenab were significantly higher. Species-wise mean concentrations of all heavy metals were non-significant (P>0.05). The mean concentrations of Cu and Ni varied significantly (P<0.01) in the liver samples from the Ravi and Chenab. Regardless of the sampling sites, the mean concentrations of Cu and Pb recorded a maximum in K. Smithi (26.54±4.53 and 3.85±0.43 mg/Kg⁻¹, respectively) Zn in K. Tecta (42.48±4.06 mg/Kg⁻¹) and Ni, Cd and Co in L. Punctata. Among the studied metals, Zn was recorded as most abundant (39.73±2.28 mg Kg⁻¹) and Cd concentration was found to be minimum (0.188±0.017 mg Kg⁻¹) in freshwater turtles collected from both sampling sites.
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