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1

Effects of 2,4-dichlorophenoxyacetic acid [2,4-D] treatment on the epididymal spermatozoa, blood serum transaminases and its accumulation in liver of rats

100%
Aydin H., Baran A., Demirel G., Yildirim M.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 12
1378-1380
Phenoxyacetic acid herbicides constitute one of the largest groups of herbicides used in the world. The study was carried out to investigate the effect of herbicide 2,4-D (2,4-Dichlorophenoxyacetic acid) on some blood parameters and toxicity of the male reproductive system of Sprague Dawley (CD) rats. The level of 2,4-D in the liver and its metabolite: 2,4-DCP was ascertained using the HPLC method and the organ weight of the livers was also determined. Three different concentrations of pesticide were used. The animals were treated orally 25 ppm and 50 ppm with water and 50 ppm and 100 ppm with food for 30 days. No significant difference was found in the blood parameters between the groups. The level of 2,4-D in the liver was found to be significantly higher in both feed and water groups compared to those of the control group (p<0.01). The level of 2,4-DCP in the liver also increased in all the experimental groups compared to control (p<0.01) groups, with the exception of the water group which had the lowest concentration. As far as the abnormal spermatozoa rates of rats were concerned, the values of the experimentally fed groups were higher than the control group and the difference between them was statistically significant (p<0.01).
2

The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy

100%
Kozan R., Ayyildiz M., Yildirim M., Agar E.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 2
177-188
The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.
3

An anatomical study of the origins of the medial circumflex femoral artery in the Turkish population

100%
Tanyeli E., Uzel M., Yildirim M., Celik H. H.
Folia Morphologica
|
2006
|
tom 65
|
nr 3
209-212
The medial circumflex femoral artery (MCFA) usually branches from the deep femoral artery (DFA). It may also branch from the femoral artery (FA). In this study 100 inguinal regions of 50 cadavers were investigated. In 79 extremities (79%) MCFA branched from DFA, while in 15 (15%) it branched from FA. In four extremities (4%) MCFA was found to be double; in each case one of MCFAs branched from FA and the other from DFA. In one of these four cases the lateral circumflex femoral artery (LCFA) was also double. In one case we found a common trunk of DFA and MCFA and in another case a common trunk of MCFA, DFA and LCFA. Clinicians must be familiar with the variations of this clinically important artery to improve their success in the diagnosis and treatment of pathologies in the region.
4

Disinfection of eggshells contaminated with Salmonella enteritidis

88%
Aksu H., Bostan K., Aydin A., Yildirim M., Keles O.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 06
641-643
The aim of the study was to investigate the effectiveness of various disinfectants on Salmonella enteritidis inoculated on eggshells. The contaminated eggs were treated with two different disinfectant solutions (benzalkonium chloride (BAG) and benzalkonium chloride / gluteraldehyde combination (BAC/G)) for 5 and 15 minutes. Following the treatment and storage at room temperature, the shells and their content were examined for S. enteritidis on days 7, 14, and 21. The results indicate that S. enteritidis may remain viable on the shells of non-disinfected eggs for a long period of time, and may penetrate into the edible portions of the egg during this period. Treating the eggs with a combination of benzalkonium chloride / gluteraldehyde for 15 minutes may probably safely eliminate the danger of S. enteritidis contamination.
5

The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

88%
Yildirim M., Marangoz A. H., Ayyildiz M., Ankarali S., Marangoz C.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr 2
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ^g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ^g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ^g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ^g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.
6
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Grain yield and nitrogen use efficiency in spring wheat (Triticum aestivum L.) hybrids under different nitrogen fertilization regimes

88%
Yildirim M., Kizilgeci F., Albayrak O., Iqbal M. A., Akinci C.
Journal of Elementology
|
2022
|
tom 27
|
nr 3
7

The effects of edaravone in ketamine-induced model of mania in rats

64%
Arslan F. C., Tiryaki A., Yildirim M., Ozkorumak E., Alver A., Altun I. K., Ince I., Gedikli O.
Acta Neurobiologiae Experimentalis
|
2016
|
tom 76
|
nr 3
Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex. Increased locomotor activity (hyperlocomotion) was observed at the open-field test with ketamine treatment (25 mg/kg, i.p., 8 days). Edaravone (18 mg/kg) treatment did not prevent hyperlocomotion in the mania model induced with ketamine in rats, but lithium chloride (47.5 mg/kg, i.p., positive control) did prevent hyperlocomotion. Edaravone and lithium chloride treatments were found to reduce the increase in SOD and CAT activity following ketamine administration in a non-significant manner but caused no change in TBARS levels.
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