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Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive Kplus channels in a gender-dependent way

100%

Kocic I., Sztormowska K.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 1

165-169

The aim of this paper was to find out how pulmonary arterial hypertension (PAH) affects heart rate in males and females rats. Additionally, the concentration of tumor necrosis factor alpha (TNF-alpha) was monitored. Male and female rats were treated by monocrotaline (i.p., 60mg/kg B.W.) or by equivalent volume of normal saline solution (n=40) and after 4 weeks right auriculae containing sinoatrial cells have been isolated and examined. We have measured heart rate of spontaneously beating right auriculae and serum level of TNF-alpha. In females with PAH, isoprenaline curve was shifted to the left (pD2 increased from 10,9±3 to 15±3, n=10, P<0,05), but in males with PAH maximal acceleration of beating rate induced by isoprenaline decreased from 175±10 to 146±8 beats/min, P<0.05). Additionally, reduction in heart rate induced by rilmakalim was more significantly decreased in females (from -89±7 to - 49±3 beats/min, n=10, p<0.01) than in males (from - 68±6 to - 46±4 beats/min, P<0.05) with PAH. We did not detect any changes in TNF-alpha in any experimental group. Our results imply that pulmonary hypertension increased sensitivity of sinoatrial cells to isoprenaline and decreased efficacy of rilmakalim to reduce heart rate more significantly in females then in males.

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4-aminopyridine induces positive lusitropic effects and prevents the negative inotropic action of phenylephrine in the rat cardiac tissue subjected to ischaemia

80%

Kocic I., Dworakowska D., Dworakowski R.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 3

3

The influence of experimental hyperlipidemia on the time course of contractility during simulated ischaemia and reperfusion and responsiveness to phenylephrine of rat heart papillary muscle

80%

Kocic I., Dworakowska D., Konstanski Z., Dworakowski R.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 3

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

3 Kocic I.

2 Dworakowska D.

2 Dworakowski R.

1 Konstanski Z.

1 Sztormowska K.

1 2009

1 1999

1 1998

Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive Kplus channels in a gender-dependent way

4-aminopyridine induces positive lusitropic effects and prevents the negative inotropic action of phenylephrine in the rat cardiac tissue subjected to ischaemia

The influence of experimental hyperlipidemia on the time course of contractility during simulated ischaemia and reperfusion and responsiveness to phenylephrine of rat heart papillary muscle