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Efficiency of selenium in attenuating epididymal histopathological changes in hypercholesterolaemic adult rat

100%

Abdel Gawad F. A., El-Shaarawy E. A. A., Rizk A. A., Sayed W. M., Emam R. A.

Folia Morphologica

2015

tom 74

nr 3

Background: Studies on sperm maturation, epididymal histology, or epididymal tubule physiology are significant parts in reproductive researches. The present study was aimed to evaluate the effect of induced hypercholesterolaemia on the epididymis of adult albino rats and to clarify the possible protective role of selenium. Materials and methods: Forty adult albino Wistar rats were divided into four groups; untreated control group (group I), sham control (group II), group with induced hypercholesterolaemia (group III), group with induced hypercholesterolaemia treated with selenium 0.25 mg/kg/day (group IV). Results: Histological and ultrastructural examination of the epididymal epithelial cells of hypercholesterolaemic rats (group III) showed loss of cilia with many vacuolations, fatty degenerative changes and increased collagen fibres. Morphometrically significant increase (p < 0.0001) in the per cent area of collagen fibres with no significant change in the optical density of periodic acid Schiff reaction (p > 0.05). Selenium treated group (group IV) produced marked improvement in histological, ultrastructural and morphometric results as compared with group III. Conclusions: It could be concluded that hypercholesterolaemia produced deleterious effects to the epididymis and selenium could attenuate these effects. (Folia Morphol 2015; 74, 3: 295–302)

Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study

100%

Abdel Gawad F. A., El-Shaarawy E. A. A., Arsanyos S. F., Abd El-Galil T. I., Awes G. N.

Folia Morphologica

2019

tom 78

nr 2

Background: Through scientific literature, there is evidence that light affects thyroid function in human, mice and rabbits. Constant light and sleep deprivation is also used as a form of human torture, as it has impact on cognitive performances. The present work was conducted to study the effect of constant light for short and long periods on the thyroid gland in the prepubertal male albino rats. Materials and methods: A total of 30 prepubertal male albino rats were used. The rats separated into three groups: group I (control); group II were those rats put under steady encompassing light (24 h/day, light intensity of 600 lux) for 4 weeks; and group III were the rats maintained in constant light for 3 months. The rat thyroid gland was subjected to histological and ultrastructural examination. Results: The rats exposed to light for long durations showed disturbed architecture; the follicles exhibited back to back arrangement (signs of hypertrophy with hyperplasia), lined by multiple layers of follicular cells or were lined by vacuolated cells. Few thyroid follicles exhibited cystic hyperplasia. Congested blood capillaries were demonstrated between the follicles. Conclusions: It can be concluded that the short-term exposure to constant light for 1 month had no apparent effect on thyroid gland tissues while longer exposure to light for 3 months had detrimental effects on the thyroid gland structure of male albino rats. (Folia Morphol 2019; 78, 2: 297–306)

Ograniczanie wyników

2 Folia Morphologica

2 Abdel Gawad F. A.

2 El-Shaarawy E. A. A.

1 Abd El-Galil T. I.

1 Arsanyos S. F.

1 Awes G. N.

1 Emam R. A.

1 Rizk A. A.

1 Sayed W. M.

1 2019

1 2015

Wyniki wyszukiwania

Efficiency of selenium in attenuating epididymal histopathological changes in hypercholesterolaemic adult rat

Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study