Wyniki wyszukiwania

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AtSec20 is involved in osmotic stress tolerance and AtSec20 mutation unaffects the integrity of intracellular organelles and the anterograde biosynthetic trafficking

100%

Zhao P., Liu F., Wang B., Yu G., Jia P., Liu H.

Acta Physiologiae Plantarum

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2013

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tom 35

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nr 05

The soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) play essential roles in intracellular trafficking. However, few experimental data have clarified their roles in the stress responses and the early secretary pathway in Arabidopsis. The AtSec20 gene encodes a protein that is homologous to yeast Sec20p and mammalian BNIP1, which are involved in the Golgi-to-ER retrograde trafficking in yeast and mammalian cells. In this study, AtSec20 is found to be required for the responses to salt stress, osmotic stress and gibberellin (GA) during seed germination and early seedling establishment. Mutation of AtSec20 unaffects the morphology of intracellular organelles, such as endoplasmic reticulum (ER), trans-Golgi network, and peroxisome, and vacuolar protein trafficking is normal in sec20 mutants. Collectively, these results imply that the AtSec20 is involved in abiotic stress tolerance, potentially via roles in retrograde vesicle fusion process in Arabidopsis.

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Factors regulating the compositions and distributions of dissolved organic matter in the estuaries of Jiaozhou Bay in North China

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Hu J., Zou L., Wang J., Ren Q., Xia B., Yu G.

Oceanologia

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2020

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tom 62

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nr 1

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Cloning a DNA marker associated to wheat scab resistance

100%

Yu G., Ma H., Xu Z., Ren L., Zhou M., Lu W.

Journal of Applied Genetics

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2004

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tom 45

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nr 1

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Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

84%

Yu G., Dong X., Tang K., Li B., Li C., Zhang W., Wang Y., Jin Y.

Cellular and Molecular Biology Letters

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2018

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tom 23

Background: Inflammation is an important pathogenic component of endotoxemiainduced acute kidney injury (AKI), finally resulting in renal failure. Diacerein is an interleukin-1β (IL-1β) inhibitor used for osteoarthritis treatment by exerting antiinflammatory effects. This study aims to investigate the effects of diacerein on endotoxemia-induced AKI. Methods: Male C57BL/6 mice were intraperitoneally injected with lipopolysaccharide (LPS, 10 mg/kg) for 24 h prior to diacerein treatment (15 mg/kg/day) for another 48 h. Mice were examined by histological, molecular and biochemical approaches. Results: LPS administration showed a time-dependent increase of IL-1β expression and secretion in kidney tissues. Diacerein treatment normalized urine volume and osmolarity, reduced blood urea nitrogen (BUN), fractional excretion of sodium (FENa), serum creatinine and osmolarity, and protected renal function in an endotoxemic AKI mice model. In the histopathologic study, diacerein also improved renal tubular damage such as necrosis of the tubular segment. Moreover, diacerein inhibited LPSinduced increase of inflammatory cytokines, such as IL-1β, tumor necrosis factor-α, monocyte chemoattractant protein-1 and nitric oxide synthase 2. In addition, LPS administration markedly decreased aquaporin 1 (AQP1), AQP2, AQP3, Na,K-ATPase α1, apical type 3 Na/H exchanger and Na-K-2Cl cotransporter expression in the kidney, which was reversed by diacerein treatment. We also found that diacerein or IL-1β inhibition prevented the secretion of inflammatory cytokines and the decrease of AQP and sodium transporter expression induced by LPS in HK-2 cells. Conclusion: Our study demonstrates for the first time that diacerein improves renal function efficiently in endotoxemic AKI mice by suppressing inflammation and altering tubular water and sodium handing. These results suggest that diacerein may be a novel therapeutic agent for the treatment of endotoxemic AKI.

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SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

68%

Jin L., Cao Y., Yu G., Wang J., Lin X., Ge L., Du J., Wang L., Diao S., Lian X., Wang S., Dong R., Shan Z.

Cellular and Molecular Biology Letters

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2017

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tom 22

Ograniczanie wyników

AtSec20 is involved in osmotic stress tolerance and AtSec20 mutation unaffects the integrity of intracellular organelles and the anterograde biosynthetic trafficking

Factors regulating the compositions and distributions of dissolved organic matter in the estuaries of Jiaozhou Bay in North China

Cloning a DNA marker associated to wheat scab resistance

Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway