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Thyroliberin dialysed into the hippocampus improves memory processes in rabit

100%

Kolodziejski P., Naziemblo B., Orlowska-Majdak M., Traczyk W. Z.

Acta Neurobiologiae Experimentalis

2001

tom 61

nr 3

Influence of thyrotropin-releasing hormone (TRH) dialyzed into the hippocampus on memory processes in rabbit

100%

Orlowska-Majdak M., Naziemblo B., Kolodziejski P.

Acta Neurobiologiae Experimentalis

2007

tom 67

nr 1

There are conflicting reports on the influence of thyrotropinreleasing hormone (TRH) on the process of learning. We decided to study this problem using the paradigm of classical eyeblink conditioning as the animal model of learning processes. During the extinction training TRH in its natural form of pGluTRH was applied into the rabbit hippocampus through a chronically implanted microdialysis probe. A Glu1TRH, analog with less biological potency than TRH as the control of specificity for TRH and a 0.9% NaCl solution as the control for both substances were applied by the same way as pGluTRH. We found that pGluTRH extended the process of extinction and enhanced the further acquisition of the reflex. The analog of TRH, Glu1TRH, was ineffective. Finally, it may be stated that TRH acting in the hippocampus prolonged process of forgetting and improved succeeding learning. The effect was specific and long lasting.

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

2 Kolodziejski P.

2 Naziemblo B.

2 Orlowska-Majdak M.

1 Traczyk W. Z.

1 2007

1 2001

Wyniki wyszukiwania

Thyroliberin dialysed into the hippocampus improves memory processes in rabit

Influence of thyrotropin-releasing hormone (TRH) dialyzed into the hippocampus on memory processes in rabbit