Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 6

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Effets od antidepressants on cytokines in experimental studies

100%
Obuchowicz E.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Cytokines play an important role as immunotransmitters and coordinate the activity of the endocrine, immune and neurotransmitter systems. The altered cytokine plasma levels have been found in some groups of depressed patients. Administration of proinfl ammatory cytokines (IL-1β, TNF-α) or unspecifi c stimulator of their synthesis – lipopolysaccharide produces in lab animals “sickness and depressive-like behavior”. These behavioral effects are attenuated by pretreatment with some antidepressants. Results of the investigation carried out on transgenic mice support suggestion that proinfl ammatory cytokines may be involved in pathogenesis of depressive symptoms. In majority of in vivo and ex vivo studies it has been observed that chronic administration of some antidepressants shifts peripheral balance between IL-1β, TNF-α and antiinfl ammatory cytokine – IL-10 towards the latter. Antiinfl ammatory and neuroprotective effects of various antidepressive drugs were confi rmed using cultured brain cells. Data from these in vitro studies indicate that antidepressants suppress IL-1β, TNF-α gene expression likely due to blockade of NFκ-B and p38 MAPK pathways. It is suggested that changes in cytokine networks might be of signifi - cance for antidepressive and/or analgesic action of antidepressants and may justify their use in therapy of neurological diseases accompanied by elevated levels of proinfl ammatory cytokines.
2

The effects of multiple administration of neuroleptics on neuropeptide Y content in the rat hypothalamus

63%
Obuchowicz E., Herman Z. S.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
3

Chronic social stress and LPS-induced inflammation have a synergistic influence on BDNF in the hypothalamus and pituitary of female rats

51%
Nowacka M., Paul-Samojedny M., Bielecka A., Obuchowicz E.
Acta Neurobiologiae Experimentalis
|
2014
|
tom 74
|
nr 3
Chronic stress, by initiating changes in the hypothalamic-pituitaryadrenal (HPA) axis and the immune system, acts as a trigger for neuropsychiatric disorders. Brain-derived neurotrophic factor (BDNF) is highly involved in regulation of HPA activity. The aim of the study was to investigate the influence of acute immunostimulation on the of BDNF in the hypothalamus and pituitary of rats subjected to chronic stress. Female Sprague-Dawley rats were subjected to 4-week stress, including phases of isolation and crowding, in an unpredictable manner. On the last day of the experiment rats being at the estrus phase were injected ip. with LPS (1 mg/kg/2 ml) or saline. Six hours later the brain structures were rapidly isolated. QRT-PCR experiments were performed using TaqMan Gene Expression Assays. The BDNF concentration was measured with a conventional ELISA assay. In the hypothalamus and pituitary of LPS-treated stressed rats BDNF mRNA expression was decreased in comparison to saline-treated stressed group. We concluded that chronic stress and inflammation have synergistic deleterious influence on BDNF in the studied structures.
4

Effect of buspirone on neuropeptide Y (NPY) content in rat brain

51%
Krysiak R., Obuchowicz E., Herman Z. S.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
5

Influence of antidepressants on LPS-induced brain-derived neurotrophic factor in hippocampus of female rats subjected to chronic social instability stress

51%
Nowacka M., Paul-Samojedny M., Bielecka A., Obuchowicz E.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr Suppl.1
It is widely accepted that chronic stress leads to the development of, and is associated with, mood disorders. Exposure to stress may intensify consequences of neuroinflammation which is considered as a crucial mechanism leading to CNS injury involving the neuroanatomical alterations in hippocampus – structure play a significant role for mechanism of action of antidepressants. Chronic treatment with some antidepressants up-regulate expression of BDNF which is the key neurotrophic factor promoting cell survival and neuroplasticity. The study was carried out to investigate the influence of desipramine, fluoxetine or tianeptine given chronically on the lipopolysaccharide (LPS) effect on the expression and the level of BDNF in hippocampus of female rats subjected to chronic stress. In the hippocampus of LPS-treated rats subjected to chronic stress, BDNF mRNA and protein levels were reduced, in comparison to the stress-group. The LPS effect was protected by treatment with studied antidepressants. The protection of BDNF against the deleterous synergistic effect induced by inflammation and chronic stress may have significance for therapeutic effects of long-term treatment with antidepressants.
6

Anxiolytic activity of metabotropic glutamate receptor group II and III ligands in rat hippocampus:the putative role of neuropeptide Y

45%
Smialowska M., Wieronska J. M., Domin H., Zieba B., Obuchowicz E.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.