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Cerebral and gastric histamine system is altered after portocaval shunt

100%

Fogel W. A., Michelsen K. A., Panula P., Sasiak K., Andrzejewski W.

Journal of Physiology and Pharmacology

2001

tom 52

nr 4,1

Biochemical parameters of the histamine (HA) system were examined in both rat brain and stomach, after portocaval anastomosis (PCA). These tissues become rich in histamine after PCA. Immunocytochemistry was used for brain histamine localisation. In addition to increased HA concentrations, monoamine oxidase B activity increased in both tissues. In hypothalamus HA was 15 fold; in cerebral cortex and in stomach mucosa 2.8 and 2.5 fold of the corresponding controls, respectively. MAO B activity was increased by approximately 50% in brain and 100% in stomach. A significant, uneven increase in tele-methylhistamine concentration was only found in the brain. In stomach mucosa higher histidine decarboxylase activity was found. PCA and sham rats treated with an irreversible inhibitor of MAO B, FA-73, 0.5 mg/kg i.p., showed 24 h later greatly reduced MAO activity and doubled t-MeHA concentration in brain structures. The treatment had no effect on gastric mucosal t-MeHA concentration and on urinary excretion of the t-MeHA metabolite, N-tele-methylimidazoleacetic acid. The HA rise in the stomach of PCA rats is associated with proliferation of histamine producing and storing cells (ECL cells) as demonstrated by others. However, in the brain we saw no indication for increased number of relevant cells either mast cells or neurons and our immunocytochemical findings suggest that in PCA rat brain, histamine deposits are located exclusively in neurons. The data indicate that the adaptative mechanisms to excessive histamine formation are tissue specific.

Histaminergic mechanisms in brain development, injury and repair

86%

Panula P., Lintunen M., Peitsaro N., Kaslin J., Michelsen K. A., Anichtchik O., Karlstedt K.

Acta Neurobiologiae Experimentalis

1999

tom 59

nr 3

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

2 Michelsen K. A.

2 Panula P.

1 Andrzejewski W.

1 Anichtchik O.

1 Fogel W. A.

1 Karlstedt K.

1 Kaslin J.

1 Lintunen M.

1 Peitsaro N.

1 Sasiak K.

1 2001

1 1999

Wyniki wyszukiwania

Cerebral and gastric histamine system is altered after portocaval shunt

Histaminergic mechanisms in brain development, injury and repair